James JA, Harley JB, Scofield RH: Epstein-Barr virus and systemic lupus erythematosus. Curr Opin Rheumatol. 2006, 18: 462-467. 10.1097/01.bor.0000240355.37927.94.
PubMed
Google Scholar
Sestak AL, Shaver TS, Moser KL, Neas BR, Harley JB: Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree. J Rheumatol. 1999, 26: 1495-1499.
CAS
PubMed
Google Scholar
Reichlin M, Harley JB, Lockshin MD: Serologic studies of monozygotic twins with systemic lupus erythematosus. Arthritis Rheum. 1992, 35: 457-464. 10.1002/art.1780350416.
CAS
PubMed
Google Scholar
Kelly JA, Moser KL, Harley JB: The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun. 2002, 3 (Suppl 1): S71-S85. 10.1038/sj.gene.6363885.
CAS
PubMed
Google Scholar
Risch N: Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet Epidemiol. 1990, 7: 3-16. 10.1002/gepi.1370070103.
CAS
PubMed
Google Scholar
Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N, Bruner GR, Fox J, Kelly J, Henshall S, et al: Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA. 1998, 95: 14869-14874. 10.1073/pnas.95.25.14869.
PubMed Central
CAS
PubMed
Google Scholar
Edberg JC, Langefeld CD, Wu J, Moser KL, Kaufman KM, Kelly J, Bansal V, Brown WM, Salmon JE, Rich SS, et al: Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum. 2002, 46: 2132-2140. 10.1002/art.10438.
CAS
PubMed
Google Scholar
Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP: Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest. 1996, 97: 1348-1354.
PubMed Central
CAS
PubMed
Google Scholar
Karassa FB, Trikalinos TA, Ioannidis JP: Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Arthritis Rheum. 2002, 46: 1563-1571. 10.1002/art.10306.
CAS
PubMed
Google Scholar
Karassa FB, Trikalinos TA, Ioannidis JP: The Fc gamma RIIIA-F158 allele is a risk factor for the development of lupus nephritis: a meta-analysis. Kidney Int. 2003, 63: 1475-1482. 10.1046/j.1523-1755.2003.00873.x.
CAS
PubMed
Google Scholar
Kimberly RP, Salmon JE, Edberg JC: Receptors for immunoglobulin G. Molecular diversity and implications for disease. Arthritis Rheum. 1995, 38: 306-314. 10.1002/art.1780380303.
CAS
PubMed
Google Scholar
Karassa FB, Trikalinos TA, Ioannidis JP: The role of Fcgam-maRIIA and IIIA polymorphisms in autoimmune diseases. Biomed Pharmacother. 2004, 58: 286-291. 10.1016/j.biopha.2004.04.004.
CAS
PubMed
Google Scholar
Prokunina L, Castillejo-Lopez C, Oberg F, Gunnarsson I, Berg L, Magnusson V, Brookes AJ, Tentler D, Kristjansdottir H, Grondal G, et al: A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet. 2002, 32: 666-669. 10.1038/ng1020.
CAS
PubMed
Google Scholar
Johansson M, Arlestig L, Moller B, Rantapaa-Dahlqvist S: Association of a PDCD1 polymorphism with renal manifestations in systemic lupus erythematosus. Arthritis Rheum. 2005, 52: 1665-1669. 10.1002/art.21058.
CAS
PubMed
Google Scholar
Lin SC, Yen JH, Tsai JJ, Tsai WC, Ou TT, Liu HW, Chen CJ: Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus. Arthritis Rheum. 2004, 50: 770-775. 10.1002/art.20040.
CAS
PubMed
Google Scholar
Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, Baechler EC, Rohlf KE, Shark KB, Espe KJ, et al: Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet. 2002, 71: 543-553. 10.1086/342290.
PubMed Central
CAS
PubMed
Google Scholar
Tsao BP, Cantor RM, Grossman JM, Shen N, Teophilov NT, Wallace DJ, Arnett FC, Hartung K, Goldstein R, Kalunian KC, et al: PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. J Clin Invest. 1999, 103: 1135-1140.
PubMed Central
CAS
PubMed
Google Scholar
Criswell LA, Moser KL, Gaffney PM, Inda S, Ortmann WA, Lin D, Chen JJ, Li H, Gray-McGuire C, Neas BR, et al: PARP alleles and SLE: failure to confirm association with disease susceptibility. J Clin Invest. 2000, 105: 1501-1502.
CAS
PubMed
Google Scholar
Delrieu O, Michel M, Frances C, Meyer O, Michel C, Wittke F, Crassard I, Bach JF, Tournier-Lasserve E, Piette JC: Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders. Arthritis Rheum. 1999, 42: 2194-2197. 10.1002/1529-0131(199910)42:10<2194::AID-ANR22>3.0.CO;2-U.
CAS
PubMed
Google Scholar
Chen JY, Wang CM, Lu SC, Chou YH, Luo SF: Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients. Clin Exp Immunol. 2006, 143: 281-287. 10.1111/j.1365-2249.2005.02984.x.
PubMed Central
CAS
PubMed
Google Scholar
Hur JW, Sung YK, Shin HD, Park BL, Cheong HS, Bae SC: Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. Rheumatology (Oxford). 2006, 45: 711-717. 10.1093/rheumatology/kei262.
CAS
Google Scholar
Nath SK, Kelly JA, Namjou B, Lam T, Bruner GR, Scofield RH, Aston CE, Harley JB: Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus. Am J Hum Genet. 2001, 69: 1401-1406. 10.1086/324470.
PubMed Central
CAS
PubMed
Google Scholar
Levinson DF, Levinson MD, Segurado R, Lewis CM: Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: methods and power analysis. Am J Hum Genet. 2003, 73: 17-33. 10.1086/376548.
PubMed Central
CAS
PubMed
Google Scholar
Lee YH, Nath SK: Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet. 2005, 118: 434-443. 10.1007/s00439-005-0073-1.
PubMed
Google Scholar
Forabosco P, Gorman JD, Cleveland C, Kelly JA, Fisher SA, Ortmann WA, Johansson C, Johanneson B, Moser KL, Gaffney PM, et al: Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. Genes Immun. 2006, 7: 609-614. 10.1038/sj.gene.6364338.
CAS
PubMed
Google Scholar
Sestak AL, Nath SK, Harley JB: Genetics of systemic lupus erythematosus: how far have we come?. Rheum Dis Clin North Am. 2005, 31: 223-244. 10.1016/j.rdc.2005.01.005.
PubMed
Google Scholar
Sullivan KE, Winkelstein JA: Genetically determined deficiencies of the complement system. Primary Immunodefieciency Diseases: A Molecular and Genetic Approach. Edited by: Ochs HD, Smith C, Puck J. 1999, New York, NY: Oxford University Press, 397-416.
Google Scholar
Sullivan KE, Petri MA, Schmeckpeper BJ, McLean RH, Winkelstein JA: Prevalence of a mutation causing C2 deficiency in systemic lupus erythematosus. J Rheumatol. 1994, 21: 1128-1133.
CAS
PubMed
Google Scholar
Agnello V: Association of systemic lupus erythematosus and SLE-like syndromes with hereditary and acquired complement deficiency states. Arthritis Rheum. 1978, 21 (5 Suppl): S146-S152.
CAS
PubMed
Google Scholar
Johnson CA, Densen P, Hurford RK, Colten HR, Wetsel RA: Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing. J Biol Chem. 1992, 267: 9347-9353.
CAS
PubMed
Google Scholar
Truedsson L, Alper CA, Awdeh ZL, Johansen P, Sjoholm AG, Sturfelt G: Characterization of type I complement C2 deficiency MHC haplotypes. Strong conservation of the complo-type/HLA-B-region and absence of disease association due to linked class II genes. J Immunol. 1993, 151: 5856-5863.
CAS
PubMed
Google Scholar
Yang Y, Chung EK, Zhou B, Lhotta K, Hebert LA, Birmingham DJ, Rovin BH, Yu CY: The intricate role of complement component C4 in human systemic lupus erythematosus. Curr Dir Autoimmun. 2004, 7: 98-132.
CAS
PubMed
Google Scholar
Hauptmann G, Tappeiner G, Schifferli JA: Inherited deficiency of the fourth component of human complement. Immunodefic Rev. 1988, 1: 3-22.
CAS
PubMed
Google Scholar
Hartung K, Baur MP, Coldewey R, Fricke M, Kalden JR, Lakomek HJ, Peter HH, Schendel D, Schneider PM, Seuchter SA: Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multi-center study. J Clin Invest. 1992, 90: 1346-1351.
PubMed Central
CAS
PubMed
Google Scholar
Sullivan KE: Genetics of systemic lupus erythematosus. Clinical implications. Rheum Dis Clin North Am. 2000, 26: 229-222. 10.1016/S0889-857X(05)70137-X.
CAS
PubMed
Google Scholar
Prodeus AP, Goerg S, Shen LM, Pozdnyakova OO, Chu L, Alicot EM, Goodnow CC, Carroll MC: A critical role for complement in maintenance of self-tolerance. Immunity. 1998, 9: 721-731. 10.1016/S1074-7613(00)80669-X.
CAS
PubMed
Google Scholar
Behrens TW, Graham RR, Kyogoku C, Baechler EC, Ramos PS, Gillett C, Bauer J, Ortmann WA, Hippen KL, Peterson E, et al: Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Novartis Found Symp. 2005, 267: 145-160.
CAS
PubMed
Google Scholar
Wilson AG, Gordon C, di Giovine FS, de Vries N, van de Putte LB, Emery P, Duff GW: A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha. Eur J Immunol. 1994, 24: 191-195. 10.1002/eji.1830240130.
CAS
PubMed
Google Scholar
Atagunduz P, Appel H, Kuon W, Wu P, Thiel A, Kloetzel PM, Sieper J: HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis. Arthritis Rheum. 2005, 52: 892-901. 10.1002/art.20948.
CAS
PubMed
Google Scholar
Palucka AK, Blanck JP, Bennett L, Pascual V, Banchereau J: Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci USA. 2005, 102: 3372-3377. 10.1073/pnas.0408506102.
PubMed Central
CAS
PubMed
Google Scholar
McCarthy DD, Summers-Deluca L, Vu F, Chiu S, Gao Y, Gommerman JL: The lymphotoxin pathway: beyond lymph node development. Immunol Res. 2006, 35: 41-54. 10.1385/IR:35:1:41.
CAS
PubMed
Google Scholar
Singer DS, Zinger H, Kohn LD, Mozes E: Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol. 1999, 29: 2259-2268. 10.1002/(SICI)1521-4141(199907)29:07<2259::AID-IMMU2259>3.0.CO;2-1.
CAS
PubMed
Google Scholar
D'Alfonso S, Giordano M, Mellai M, Lanceni M, Barizzone N, Marchini M, Scorza R, Danieli MG, Cappelli M, Rovere P, et al: Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5' regulatory region. Genes Immun. 2002, 3: 454-463. 10.1038/sj.gene.6363928.
PubMed
Google Scholar
Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB, Sestak AL: The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum. 2005, 52: 3966-3974. 10.1002/art.21484.
CAS
PubMed
Google Scholar
Lee YH, Harley JB, Nath SK: CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet. 2005, 116: 361-367. 10.1007/s00439-004-1244-1.
CAS
PubMed
Google Scholar
Lee YH, Harley JB, Nath SK: Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet. 2006, 14: 364-371. 10.1038/sj.ejhg.5201566.
CAS
PubMed
Google Scholar
Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB: The PTPN22 C1858T functional polymorphism and autoimmune diseases: a meta-analysis. Rheumatology (Oxford). 2006, 46: 49-56. 10.1093/rheumatology/kel170.
Google Scholar
Lee YH, Rho YH, Choi SJ, Ji JD, Song GG: Angiotensin-converting enzyme insertion/deletion polymorphism and systemic lupus erythematosus: a metaanalysis. J Rheumatol. 2006, 33: 698-702.
CAS
PubMed
Google Scholar
Bagavant H, Fu SM: New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells. Curr Opin Rheumatol. 2005, 17: 523-528. 10.1097/01.bor.0000169361.23325.1e.
CAS
PubMed
Google Scholar
Chen YF, Morel L: Genetics of T cell defects in lupus. Cell Mol Immunol. 2005, 2: 403-409.
CAS
PubMed
Google Scholar
Cunninghame Graham DS, Vyse TJ: The candidate gene approach: have murine models informed the study of human SLE?. Clin Exp Immunol. 2004, 137: 1-7. 10.1111/j.1365-2249.2004.02525.x.
PubMed Central
CAS
PubMed
Google Scholar
Lauwerys BR, Wakeland EK: Genetics of lupus nephritis. Lupus. 2005, 14: 2-12. 10.1191/0961203305lu2052oa.
CAS
PubMed
Google Scholar
Morel L: Mouse models of human autoimmune diseases: essential tools that require the proper controls. PLoS Biol. 2004, 2: E241-10.1371/journal.pbio.0020241.
PubMed Central
PubMed
Google Scholar
Rigby RJ, Fernando MM, Vyse TJ: Mice, humans and haplotypes: the hunt for disease genes in SLE. Rheumatology (Oxford). 2006, 45: 1062-1067. 10.1093/rheumatology/kel088.
CAS
Google Scholar
Nguyen C, Limaye N, Wakeland EK: Susceptibility genes in the pathogenesis of murine lupus. Arthritis Res. 2002, 4 (Suppl 3): S255-S263. 10.1186/ar583.
PubMed Central
PubMed
Google Scholar
Wandstrat A, Wakeland E: The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol. 2001, 2: 802-809. 10.1038/ni0901-802.
CAS
PubMed
Google Scholar
Nose M, Nishihara M, Kamogawa J, Terada M, Nakatsuru S: Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci. Rev Immunogenet. 2000, 2: 154-164.
CAS
PubMed
Google Scholar
Campagnoli MF, Garbarini L, Quarello P, Garelli E, Carando A, Baravalle V, Doria A, Biava A, Chiocchetti A, Rosolen A, et al: The broad spectrum of autoimmune lymphoproliferative disease: molecular bases, clinical features and long-term follow-up in 31 patients. Haematologica. 2006, 91: 538-541.
CAS
PubMed
Google Scholar
Lachmann PJ: Lupus and desoxyribonuclease. Lupus. 2003, 12: 202-206. 10.1191/0961203303lu357xx.
CAS
PubMed
Google Scholar
Tao K, Yasutomo K: SLE caused by DNase 1 gene mutation [in Japanese]. Nippon Rinsho. 2005, 63 (Suppl 5): 205-209.
PubMed
Google Scholar
Yasutomo K, Horiuchi T, Kagami S, Tsukamoto H, Hashimura C, Urushihara M, Kuroda Y: Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet. 2001, 28: 313-314. 10.1038/91070.
CAS
PubMed
Google Scholar
Botto M: C1q knock-out mice for the study of complement deficiency in autoimmune disease. Exp Clin Immunogenet. 1998, 15: 231-234. 10.1159/000019076.
CAS
PubMed
Google Scholar
Clynes R, Dumitru C, Ravetch JV: Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science. 1998, 279: 1052-1054. 10.1126/science.279.5353.1052.
CAS
PubMed
Google Scholar
Subramanian S, Tus K, Li QZ, Wang A, Tian XH, Zhou J, Liang C, Bartov G, McDaniel LD, Zhou XJ, et al: A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA. 2006, 103: 9970-9975. 10.1073/pnas.0603912103.
PubMed Central
CAS
PubMed
Google Scholar
Pascual V, Farkas L, Banchereau J: Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol. 2006, 18: 676-682. 10.1016/j.coi.2006.09.014.
CAS
PubMed
Google Scholar
Lee JY, Goldman D, Piliero LM, Petri M, Sullivan KE: Interferon-gamma polymorphisms in systemic lupus erythematosus. Genes Immun. 2001, 2: 254-257. 10.1038/sj.gene.6363775.
CAS
PubMed
Google Scholar
Nakashima H, Inoue H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E, Nagano S, Arinobu Y, Niiro H, Otsuka T, et al: The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus. FEBS Lett. 1999, 453: 187-190. 10.1016/S0014-5793(99)00701-2.
CAS
PubMed
Google Scholar
Hrycek A, Siekiera U, Cieslik P, Szkrobka W: HLA-DRB1 and -DQB1 alleles and gene polymorphisms of selected cytokines in systemic lupus erythematosus. Rheumatol Int. 2005, 26: 1-6. 10.1007/s00296-004-0503-8.
CAS
PubMed
Google Scholar
Tanaka Y, Nakashima H, Hisano C, Kohsaka T, Nemoto Y, Niiro H, Otsuka T, Otsuka T, Imamura T, Niho Y: Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus. Immunogenetics. 1999, 49: 266-271. 10.1007/s002510050492.
CAS
PubMed
Google Scholar
Yao X, Li YM, Hu ZJ, Li WZ, Chen ZQ: Polymorphisms within the interferon-Gamma receptor associated with systemic lupus erythematosus [in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005, 22: 320-323.
CAS
PubMed
Google Scholar
Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Moller B, Kere J, et al: Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet. 2005, 76: 528-537. 10.1086/428480.
PubMed Central
CAS
PubMed
Google Scholar
Graham DS, Manku H, Wagner S, Reid J, Timms K, Gutin A, Lanchbury JS, Vyse TJ: Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation. Hum Mol Genet. 2007, 16: 579-591. 10.1093/hmg/ddl469.
PubMed Central
Google Scholar
Demirci FY, Manzi S, Ramsey-Goldman R, Minster RL, Kenney M, Shaw PS, Dunlop-Thomas CM, Kao AH, Rhew E, Bontempo F, et al: Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE). Ann Hum Genet. 2007, 71: 308-311. 10.1111/j.1469-1809.2006.00336.x.
CAS
PubMed
Google Scholar
Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T, Gonzalez Escribano MF, Pons-Estel B, et al: A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet. 2006, 38: 550-555. 10.1038/ng1782.
CAS
PubMed
Google Scholar
Sawalha AH, Richardson BC: DNA methylation in the pathogenesis of systemic lupus erythematosus. Curr Pharmacogenom. 2005, 3: 73-78. 10.2174/1570160053174983.
CAS
Google Scholar
Busslinger M, Hurst J, Flavell RA: DNA methylation and the regulation of globin gene expression. Cell. 1983, 34: 197-206. 10.1016/0092-8674(83)90150-2.
CAS
PubMed
Google Scholar
Attwood JT, Yung RL, Richardson BC: DNA methylation and the regulation of gene transcription. Cell Mol Life Sci. 2002, 59: 241-257. 10.1007/s00018-002-8420-z.
CAS
PubMed
Google Scholar
Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M: Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 1990, 33: 1665-1673. 10.1002/art.1780331109.
CAS
PubMed
Google Scholar
Deng C, Kaplan MJ, Yang J, Ray D, Zhang Z, McCune WJ, Hanash SM, Richardson BC: Decreased Rasmitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum. 2001, 44: 397-407. 10.1002/1529-0131(200102)44:2<397::AID-ANR59>3.0.CO;2-N.
CAS
PubMed
Google Scholar
Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B: Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol. 1988, 140: 2197-2200.
CAS
PubMed
Google Scholar
Deng C, Lu Q, Zhang Z, Rao T, Attwood J, Yung R, Richardson B: Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum. 2003, 48: 746-756. 10.1002/art.10833.
CAS
PubMed
Google Scholar
Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC: Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol. 1995, 154: 3025-3035.
CAS
PubMed
Google Scholar
Ballestar E, Esteller M, Richardson BC: The epigenetic face of systemic lupus erythematosus. J Immunol. 2006, 176: 7143-7147.
CAS
PubMed
Google Scholar
Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L: Several genes contribute to the production of autore-active B and T cells in the murine lupus susceptibility locus sle1c. J Immunol. 2005, 175: 1080-1089.
CAS
PubMed
Google Scholar
Johanneson B, Lima G, von Salome J, Alarcon-Segovia D, Alarcon-Riquelme ME: A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31. Am J Hum Genet. 2002, 71: 1060-1071. 10.1086/344289.
PubMed Central
CAS
PubMed
Google Scholar
Shai R, Quismorio FP, Li L, Kwon OJ, Morrison J, Wallace DJ, Neuwelt CM, Brautbar C, Gauderman WJ, Jacob CO: Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families. Hum Mol Genet. 1999, 8: 639-644. 10.1093/hmg/8.4.639.
CAS
PubMed
Google Scholar
Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, Arnasson A, Grondal G, Jonasson I, Magnusson V, Sturfelt G, Truedsson L, et al: A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J Autoimmun. 2000, 14: 169-178. 10.1006/jaut.1999.0357.
CAS
PubMed
Google Scholar
Morel L, Tian XH, Croker BP, Wakeland EK: Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity. 1999, 11: 131-139. 10.1016/S1074-7613(00)80088-6.
CAS
PubMed
Google Scholar
Gray-McGuire C, Moser KL, Gaffney PM, Kelly J, Yu H, Olson JM, Jedrey CM, Jacobs KB, Kimberly RP, Neas BR, et al: Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Am J Hum Genet. 2000, 67: 1460-1469. 10.1086/316891.
PubMed Central
CAS
PubMed
Google Scholar
Xing C, Sestak AL, Kelly JA, Nguyen KL, Bruner GR, Harley JB, Gray-McGuire C: Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet. 2007, 120: 623-631. 10.1007/s00439-006-0248-4.
CAS
PubMed
Google Scholar
Subramanian S, Yim YS, Liu K, Tus K, Zhou XJ, Wakeland EK: Epistatic suppression of systemic lupus erythematosus: fine mapping of sles1 to less than 1 mb. J Immunol. 2005, 175: 1062-1072.
CAS
PubMed
Google Scholar
Cantor RM, Yuan J, Napier S, Kono N, Grossman JM, Hahn BH, Tsao BP: Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23. Arthritis Rheum. 2004, 50: 3203-3210. 10.1002/art.20511.
CAS
PubMed
Google Scholar
Quintero-Del-Rio AI, Kelly JA, Garriott CP, Hutchings DC, Frank SG, Aston CE, Harley JB: SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis. Am J Hum Genet. 2004, 75: 346-348. 10.1086/422460.
PubMed Central
CAS
PubMed
Google Scholar
Quintero-Del-Rio AI, Kelly JA, Kilpatrick J, James JA, Harley JB: The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3). Genes Immun. 2002, 3 (Suppl 1): S57-S62. 10.1038/sj.gene.6363901.
CAS
PubMed
Google Scholar
Nath SK, Quintero-Del-Rio AI, Kilpatrick J, Feo L, Ballesteros M, Harley JB: Linkage at 12q24 with systemic lupus erythematosus (SLE) is established and confirmed in Hispanic and European American families. Am J Hum Genet. 2004, 74: 73-82. 10.1086/380913.
PubMed Central
CAS
PubMed
Google Scholar
Gaffney PM, Ortmann WA, Selby SA, Shark KB, Ockenden TC, Rohlf KE, Walgrave NL, Boyum WP, Malmgren ML, Miller ME, et al: Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am J Hum Genet. 2000, 66: 547-556. 10.1086/302767.
PubMed Central
CAS
PubMed
Google Scholar
Nath SK, Namjou B, Hutchings D, Garriott CP, Pongratz C, Guthridge J, James JA: Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity. Eur J Hum Genet. 2004, 12: 668-672. 10.1038/sj.ejhg.5201209.
CAS
PubMed
Google Scholar
Namjou B, Nath SK, Kilpatrick J, Kelly JA, Reid J, James JA, Harley JB: Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Arthritis Rheum. 2002, 46: 2937-2945. 10.1002/art.10588.
CAS
PubMed
Google Scholar
Nath SK, Namjou B, Garriott CP, Frank S, Joslin PA, Kilpatrick J, Kelly JA, Harley JB: Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. Genes Immun. 2004, 5: 209-214. 10.1038/sj.gene.6364060.
CAS
PubMed
Google Scholar
Namjou B, Kelly JA, Kilpatrick J, Kaufman KM, Nath SK, Scofield RH, Harley JB: Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease. Arthritis Rheum. 2005, 52: 3646-3650. 10.1002/art.21413.
CAS
PubMed
Google Scholar
Nath SK, Namjou B, Kilpatrick J, Garriott CP, Bruner GR, Scofield RH, Harley JB: A candidate region on 11p13 for systemic lupus erythematosus: a linkage identified in African-American families. J Investig Dermatol Symp Proc. 2004, 9: 64-67. 10.1111/j.1087-0024.2004.00830.x.
PubMed
Google Scholar
Scofield RH, Bruner GR, Kelly JA, Kilpatrick J, Bacino D, Nath SK, Harley JB: Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood. 2003, 101: 992-997. 10.1182/blood-2002-04-1003.
CAS
PubMed
Google Scholar
Kelly JA, Thompson K, Kilpatrick J, Lam T, Nath SK, Gray-McGuire C, Reid J, Namjou B, Aston CE, Bruner GR, et al: Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia. Proc Natl Acad Sci USA. 2002, 99: 11766-11771. 10.1073/pnas.182162399.
PubMed Central
CAS
PubMed
Google Scholar
Sawalha AH, Namjou B, Nath SK, Kilpatrick J, Germundson A, Kelly JA, Hutchings D, James J, Harley J: Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern. Genes Immun. 2002, 3 (Suppl 1): S31-S34. 10.1038/sj.gene.6363904.
CAS
PubMed
Google Scholar
Spritz RA, Gowan K, Bennett DC, Fain PR: Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. Am J Hum Genet. 2004, 74: 188-191. 10.1086/381134.
PubMed Central
CAS
PubMed
Google Scholar
Namjou B, Nath SK, Kilpatrick J, Kelly JA, Reid J, Reichlin M, James JA, Harley JB: Genome scan stratified by the presence of anti-double-stranded DNA (dsDNA) autoantibody in pedigrees multiplex for systemic lupus erythematosus (SLE) establishes linkages at 19p13.2 (SLED1) and 18q21.1 (SLED2). Genes Immun. 2002, 3 (Suppl 1): S35-S41. 10.1038/sj.gene.6363905.
CAS
PubMed
Google Scholar
Hogarth MB, Slingsby JH, Allen PJ, Thompson EM, Chandler P, Davies KA, Simpson E, Morley BJ, Walport MJ: Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. J Immunol. 1998, 161: 2753-2761.
CAS
PubMed
Google Scholar