Table 3 Genes associated with systemic lupus erythematosus
Gene name | Locus ID | Location | Evidence |
|---|---|---|---|
C1Q | 712 | 1p36 | Causative mutations found [27,35] |
C2 | 717 | 6p21 | Causative mutations found [28,29] |
C4 | 721 | 6p21 | Causative mutations found [33,35] |
PTPN22 | 26,191 | 1p13 | Meta-analysis [47] |
FCGR2A | 2,212 | 1q23 | Meta-analysis [9,12] |
FCGR3A | 2,214 | 1q23 | Meta-analysis [10,12] |
IL10 | 3,586 | 1q32 | Meta-analysis [43] |
CTLA4 | 1,493 | 2q33 | Meta-analysis [45] |
HLA-DRB1 | 3,123 | 6p21 | Multiple positive reports [4,26,37] |
TNFα | 7,124 | 6p21 | Meta-analysis [46] |
TNFβ | 4,049 | 6p21 | Multiple positive reports [26] |
MBL | 4,153 | 10q11 | Meta-analysis [44] |