Skip to main content

Class switched memory B cells are enriched in the synovium after rituximab treatment

A 49-year-old female was diagnosed with polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis at the age of 15. Advanced destruction required bilateral knee joint replacement 8 years later. Persistent inflammatory activity led to rituximab treatment (1,000 mg on days 1 and 15) in an advanced disease stage. Peripheral blood analyses showed immediate B-cell depletion. Synovial tissue histology 8 months later in the early reconstitution phase revealed scattered follicular-like infiltrates including CD20+ B cells. Flow cytometry of homogenized tissue showed CD19+ B cells predominantly representing an IgD-CD27+ class switched memory phenotype, which was contrasted by >90% IgD+CD27- peripheral blood B cells. This observation, which indicates either local persistence or early B-cell repopulation and a composition of synovial B cells discordant to peripheral blood, could have an impact on the future development of monitoring strategies after rituximab treatment in arthritis.

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Möller, B., Vajtai, I., Adler, S. et al. Class switched memory B cells are enriched in the synovium after rituximab treatment. Arthritis Res Ther 9 (Suppl 3), P24 (2007).

Download citation

  • Published:

  • DOI:


  • Arthritis
  • Juvenile Idiopathic Arthritis
  • Synovial Tissue
  • Joint Replacement
  • Inflammatory Activity