Volume 9 Supplement 3

6th Global Arthritis Research Network (GARN) Meeting

Meeting abstracts

Edited by Steffen Gay and Peter E Lipsky

6th Global Arthritis Research Network (GARN) Meeting. Go to conference site.

Zurich, Switzerland10-13 May 2007

IL-21 modulates cytokine levels in murine collagen-induced arthritis and contributes to disease pathology

Authors: DA Young, M Hegen, H Ma, L Napierata, J Lamothe, M Senices, L Lowe, M Collins and C Nickerson-Nutter

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P1

Content type: Poster presentation Published on: 19 October 2007
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Combined anti-inflammatory tritherapy using a novel small interfering RNA lipoplex successfully prevents and cures mice of arthritis

Authors: M Khoury, V Escriou, A Galy, R Yao, C Largeau, D Scherman, C Jorgensen and F Apparailly

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P2

Content type: Poster presentation Published on: 19 October 2007
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An integrative genomics strategy for the identification of collagen-induced arthritis susceptibility genes

Authors: Saleh M Ibrahim

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P3

Content type: Poster presentation Published on: 19 October 2007
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Tumour necrosis factor-dependent inflammatory cartilage destruction

Authors: A Korb, B Tuerk, F Echtermeyer, T Pap, JS Smolen and K Redlich

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P4

Content type: Poster presentation Published on: 19 October 2007
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Histidine deficiency does not protect against aggrecan-induced arthritis

Authors: Gyorgy Nagy, Marianna Csilla Holub, Karoly Németh, Maria Pasztoi, Mercedesz Mazan, Agnes Koncz, Andras Falus and Edit Buzas

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P5

Content type: Poster presentation Published on: 19 October 2007
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Mast cells jump start K/BxN serum transfer arthritis via IL-1

Authors: PA Nigrovic, A Johnsen, BA Binstadt, PA Monach, M Gurish, Y Iwakura, D Mathis, C Benoist and DM Lee

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P6

Content type: Poster presentation Published on: 19 October 2007
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Disrupting Mer receptor tyrosine kinase expression prevents autoimmune chronic graft-versus-host disease

Authors: Wen-Hai Shao, Robert A Eisenberg and Philip L Cohen

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P7

Content type: Poster presentation Published on: 19 October 2007
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IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from human marginal zone B cells as well as from circulating peripheral blood B cells from autoimmune patients

Authors: Rachel Ettinger, Stefan Kuchen, Gary P Sims, Rachel Robbins, David Withers, Randy T Fischer and Peter E Lipsky

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P8

Content type: Poster presentation Published on: 19 October 2007
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IL-33: a novel cytokine with proinflammatory properties

Authors: Gaby Palmer, David Moulin, Olivier Donzé, Dominique Talabot-Ayer and Cem Gabay

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P9

Content type: Poster presentation Published on: 19 October 2007
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Tolerogenic dendritic cells differentially modulate naïve and memory CD4⁺ T cells

Authors: Amy E Anderson, Bethan Sayers, Julie Diboll, John D Isaacs and Catharien MU Hilkens

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P10

Content type: Poster presentation Published on: 19 October 2007
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Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties

Authors: Bethan Sayers, Muzlifah Haniffa, Julie Diboll, John Isaacs and Catharien Hilkens

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P11

Content type: Poster presentation Published on: 19 October 2007
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Arthritis induced by systemic autoimmunity against glucose-6-phosphate isomerase in normal mice

Authors: T Kamradt, L Bruns, O Frey, L Morawietz, D Schubert and A Taubner

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P12

Content type: Poster presentation Published on: 19 October 2007
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Regulation of eicosanoid production in peripheral blood mononuclear cells from patients with systemic sclerosis

Authors: Otylia Kowal-Bielecka, Krzysztof Kowal, Justyna Chwiecko, Stanislaw Sierakowski, Oliver Distler, Sylwia Chwiesko, Izabela Domyslawska and Steffen Gay

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P13

Content type: Poster presentation Published on: 19 October 2007
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Characterization of immunoglobulin mutations in humans with activation-induced cytidine deaminase deficiency

Authors: Nancy S Longo, Colleen Satorius, Anne Durandy and Peter E Lipsky

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P14

Content type: Poster presentation Published on: 19 October 2007
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CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival

Authors: F Barone, M Bombardieri, J Spencer, P Isaacson, F Humby, P Morgan, S Challacombe, G Valesini and C Pitzalis

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P15

Content type: Poster presentation Published on: 19 October 2007
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Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles

Authors: KN Verpoort, K Cheung, A Ioan-Facsinay, AHM van der Helm-van Mil, RRP de Vries, FC Breedveld, TWJ Huizinga, GJM Pruijn and REM Toes

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P16

Content type: Poster presentation Published on: 19 October 2007
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Activation of synovial fibroblasts by laminin-1 and transforming growth factor beta induces expression of stromelysins independently of TNFα, IL-1β or NF-κB

Authors: Katrin Warstat, Thomas Pap, Gerd Klein, Steffen Gay and Wilhelm K Aicher

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P17

Content type: Poster presentation Published on: 19 October 2007
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Tumor necrosis factor polymorphisms in psoriatic arthritis: association with the promoter polymorphism TNF-857 independent of the PSORS1 risk allele

Authors: K Reich, U Hüffmeier, IR König, J Lascorz, J Lohmann, J Wendler, H Traupe, R Mössner, A Reis and H Burkhardt

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P18

Content type: Poster presentation Published on: 19 October 2007
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Safety and diagnostic value of medical arthroscopy: retrospective analysis of 100 medical arthroscopies performed by a rheumatologist

Authors: Ved Chaturvedi

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P19

Content type: Poster presentation Published on: 19 October 2007
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Investigation of the role of the p38 MAPK α and δ isoforms in nonresponse to tumour necrosis factor blockade in the synovium of rheumatoid arthritis patients

Authors: LR Coulthard, LD Church, RJ Mathews, S Churchman, L Dickie, M Buch, R Reece, A English, AW Morgan, S Gay, P Emery and MF McDermott

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P20

Content type: Poster presentation Published on: 19 October 2007
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The synovial cadherin (cadherin-11) promotes intercellular motility

Authors: Hans P Kiener, Christopher S Stipp, Philip G Allen, David M Lee and Michael B Brenner

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P21

Content type: Poster presentation Published on: 19 October 2007
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Cadherin-11 regulates synovial fibroblast behavior in health and disease

Authors: David M Lee, Hans P Kiener, Sandeep K Agarwal, Erika H Noss, Gerald FM Watts, Osamu Chisaka, Masatoshi Takeichi and Michael B Brenner

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P22

Content type: Poster presentation Published on: 19 October 2007
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Toll-like receptor 9 agonists and IL-15 promote activation, proliferation, secretion of proinflammatory cytokines and differentiation of B cells isolated from bone marrow of rheumatoid arthritis patients

Authors: W Rudnicka, E Warnawin, T Burakowski, M Bik, E Kontny, M Chorazy-Massalska, A Radzikowska, M Buler, P Maldyk and W Maslinski

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P23

Content type: Poster presentation Published on: 19 October 2007
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Class switched memory B cells are enriched in the synovium after rituximab treatment

Authors: Burkhard Möller, Istvan Vajtai, Sabine Adler, Stefan Eggli, Hans-Rudolf Ziswiler, Clemens Dahinden and Peter M Villiger

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P24

Content type: Poster presentation Published on: 19 October 2007
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Evidence for the role of CD74 in innate immunity, arthritis, and the action of migration inhibitory factor

Authors: Eric Morand, Lanie Santos, Pamela Hall and Michael Hickey

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P25

Content type: Poster presentation Published on: 19 October 2007
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Nitric oxide differentially regulates T-cell function in rheumatoid arthritis and systemic lupus erythematosus

Authors: Gyorgy Nagy, Joanna M Clark, Edit Buzas, Claire L Gorman, Pal Geher, Andras Perl, Andras Falus and Andrew P Cope

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P26

Content type: Poster presentation Published on: 19 October 2007
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Circulating levels of IL-7 in rheumatoid arthritis

Authors: S Churchman, S Field, C Burgoyne, A Brown, P Emery and F Ponchel

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P27

Content type: Poster presentation Published on: 19 October 2007
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The regulation of IL-7 production in synovial stromal cells in rheumatoid arthritis is promiscuous

Authors: S Field, E Jones, A English, C Burgoyne, S Churchman, R Reece, P Emery and F Ponchel

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P28

Content type: Poster presentation Published on: 19 October 2007
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Mesenchymal stem cell repair capabilities are defective in rheumatoid arthritis in relation with in vivo exposure to inflammation

Authors: E Jones, S Field, A English, R Reece, P Emery, D McGonagle and F Ponchel

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P29

Content type: Poster presentation Published on: 19 October 2007
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Diagnostic value of anticyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis: association with extra-articular manifestations

Authors: Ioannis Alexiou, Anastasios Germenis, Athanasios Ziogas, Athanasios Koutroumbas, Katerina Theodoridou, Anastasia Kontogianni and Lazaros I Sakkas

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P30

Content type: Poster presentation Published on: 19 October 2007
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Phase 1 study of TRU-015, a CD20-directed small modular immunopharmaceutical (SMIP™) protein therapeutic, in subjects with rheumatoid arthritis

Authors: DJ Burge, SA Bookbinder, AJ Kivitz, RM Fleischmann, C Shu, J Bannink and D Barone

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P31

Content type: Poster presentation Published on: 19 October 2007
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TRU-015, a small modular immunopharmaceutical (SMIP™) drug candidate directed against CD20, demonstrates clinical improvement in subjects with rheumatoid arthritis

Authors: DJ Burge, C Shu, RW Martin, TW Littlejohn, DJ Wallace, J Taborn, WR Palmer and A Kivitz

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P32

Content type: Poster presentation Published on: 19 October 2007
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Quantiferon-TB Gold test in screening for latent tuberculosis before and during antitumour necrosis factor treatment

Authors: J Vencovský, M Havelková, Š Forejtová, K Jarošová and I Pùtová

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P33

Content type: Poster presentation Published on: 19 October 2007
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Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes

Authors: H Afif, L Mfuna, J Martel-Pelletier, J-P Pelletier and H Fahmi

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P34

Content type: Poster presentation Published on: 19 October 2007
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Abnormal collagen type 1 production in subchondral osteoarthritic osteoblasts is responsible in part for altered mineralization in these cells

Authors: Denis Chouchourel, Geneviève Bariteau, Aline Delalandre and Daniel Lajeunesse

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P35

Content type: Poster presentation Published on: 19 October 2007
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Altered expression and production of leptin is responsible for abnormal cell markers in subchondral osteoblasts from osteoarthritic patients

Authors: Daniel Lajeunesse, Marie-Solange Mutabaruka, Mohamed Aoulab-Aissa and Aline Delalandre

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P36

Content type: Poster presentation Published on: 19 October 2007
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Molecular mechanisms involved in a differential association of Frzb biology with osteoarthritis and osteoporosis

Authors: Rik JU Lories, Jan Schrooten, Inge Derese, Jenny Peeters, Astrid Bakker and Frank P Luyten

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P37

Content type: Poster presentation Published on: 19 October 2007
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Matrix remodeling during enchondral ossification and aggrecan cleavage in osteoarthritic cartilage depends on syndecan-4

Authors: Frank Echtermeyer, Katja Neugebauer, Ingmar Meinecke, Christine Herzog, Rita Dreier and Thomas Pap

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P38

Content type: Poster presentation Published on: 19 October 2007
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Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Authors: Qian Zhang, Wang Hui, Rose Davidson, Clare Darrah, Simon T Donell, Ian M Clark, Tim E Cawston, John H Robinson, Andrew D Rowan and David A Young

Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P39

Content type: Poster presentation Published on: 19 October 2007
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6th Global Arthritis Research Network (GARN) Meeting

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