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Table 1 Patient characteristics

From: Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept

Patient number

Age (years)

Gender

RA duration (years)

Disease-modifying antirheumatic drugs

Steroids (mg/day)

CCP-Ab (U/ml) (t0)

DAS28

X-ray progression

Response after 3 months

       

Baseline

3 months

  

1

77

Male

21

None

5.0

644

5.45

4.69

No

Nonresponder

2

64

Male

27

Leflunomide

10.0

610

5.18

4.61

No

Nonresponder

3

43

Female

33

Methotrexate

7.5

81

4.82

0.69

No

Responder

4

65

Female

45

None

15.0

187

6.00

6.44

Yes

Nonresponder

5

63

Female

8

None

15.0

>1,600

5.83

8.37

Yes

Nonresponder

6

51

Female

17

Methotrexate

20.0

Negative

6.16

4.40

Yes

Nonresponder

7

34

Female

9

None

0.0

806

5.37

5.47

Yes

Nonresponder

8

44

Male

9

None

15.0

Negative

5.51

2.55

No

Responder

9

39

Male

1

Methotrexate

5.0

Negative

5.12

2.09

No

Responder

10

42

Female

29

Methotrexate

7.5

Negative

6.52

1.79

No

Responder

11

26

Female

2

None

0.0

Negative

4.47

1.50

No

Responder

12

48

Female

24

Leflunomide

8.0

429

5.57

2.73

No

Responder

13

47

Female

13

Cyclosporin A

10.0

96

7.11

5.29

No

Responder

14

53

Female

5

Leflunomide

8.0

1064

3.29

2.42

No

Nonresponder

15

62

Female

13

Methotrexate

0.0

Neg.

5.88

4.40

No

Responder

16

65

Female

2

Sulfasalazine/hydroxychloroquin

15.0

>1,600

7.68

5.90

No

Responder

17

42

Female

14

None

5.0

61

5.6

3.36

No

Responder

18

52

Female

8

Methotrexate

0.0

436

5.59

2.38

No

Responder

19

70

Female

14

Leflunomide

7.5

855

5.08

2.55

No

Responder

  1. Therapeutic response was defined clinically by changes of 28-joint-count Disease Activity Score (DAS28) determined at the beginning of the study (baseline) and 3 months after the start of etanercept treatment and additionally by X-ray analysis of hands and feet after 9 to 12 months. An improvement of the DAS28 by >1.2 was considered a good response (if no progression of joint destruction were observed by X-ray analysis), a DAS28 reduction by ≤ 1.2 was considered a nonresponse. Serum antibodies to cyclic citrullinated peptide (CCP-Ab) were analysed using the Immunoscan RA ELISA CCP2 test (Euro-Diagnostica, Malmö, Sweden) according to the manufacturer's instructions (cutoff point = 25 U/ml). RA, rheumatoid arthritis.