Brennan FM, Maini RN, Feldmann M: Role of pro-inflammatory cytokines in rheumatoid arthritis. Springer Semin Immunopathol. 1998, 20: 133-147. 10.1007/BF00832003.
Article
CAS
PubMed
Google Scholar
Bathon JM, Genovese MC: The Early Rheumatoid Arthritis (ERA) trial comparing the efficacy and safety of etanercept and methotrexate. Clin Exp Rheumatol. 2003, 21: S195-S197.
CAS
PubMed
Google Scholar
Keystone EC, Schiff MH, Kremer JM, Kafka S, Lovy M, DeVries T, Burge DJ: Once-weekly administration of 50 mg etanercept in patients with active rheumatoid arthritis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2004, 50: 353-363. 10.1002/art.20019.
Article
CAS
PubMed
Google Scholar
Brennan A, Bansback N, Reynolds A, Conway P: Modelling the cost-effectiveness of etanercept in adults with rheumatoid arthritis in the UK. Rheumatology. 2004, 43: 62-72. 10.1093/rheumatology/keg451.
Article
CAS
PubMed
Google Scholar
Klareskog L, Heijde van der D, de Jager JP, Gough A, Kalden J, Malaise M, Martín Mola E, Pavelka K, Sany J, Settas L, Wajdula J, Pedersen R, Fatenejad S, Sanda M: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004, 363: 675-681. 10.1016/S0140-6736(04)15640-7.
Article
CAS
PubMed
Google Scholar
Hyrich KL, Watson KD, Silman AJ, Symmons DP: Predictors of response to anti-TNF-α therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology. 2006, 45: 1558-1565. 10.1093/rheumatology/kel149.
Article
CAS
PubMed
Google Scholar
Bobbio-Pallavicini F, Alpini C, Caporali R, Avalle S, Bugatti S, Montecucco C: Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment. Arthritis Res Ther. 2004, 6: R264-R272. 10.1186/ar1173.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kekow J, Wollenberg H, Kühne C, Drynda A, Drynda S: Clinical significance of anti-cyclic citrullinated peptide (CCP) antibodies in monitoring patients with rheumatoid arthritis (RA) treated with etanercept. Arthritis Rheum. 2005, 52: s550-abstract
Google Scholar
Ranganathan P: Pharmacogenomics of tumor necrosis factor antagonists in rheumatoid arthritis. Pharmacogenomics. 2005, 6: 481-490. 10.2217/14622416.6.5.481.
Article
CAS
PubMed
Google Scholar
Kang CP, Lee KW, Yoo DH, Kang C, Bae SC: The influence of a polymorphism at position -857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis. Rheumatology. 2005, 44: 547-552. 10.1093/rheumatology/keh550.
Article
CAS
PubMed
Google Scholar
Lee YH, Rho YH, Choi SJ, Ji JD, Song GG: Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatol Int. 2006, 27: 157-161. 10.1007/s00296-006-0175-7.
Article
CAS
PubMed
Google Scholar
Schotte H, Schluter B, Drynda S, Willeke P, Tidow N, Assmann G, Domschke W, Kekow J, Gaubitz M: Interleukin 10 promoter microsatellite polymorphisms are associated with response to long term treatment with etanercept in patients with rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 575-581. 10.1136/ard.2004.027672.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ulfgren AK, Andersson U, Engstrom M, Klareskog L, Maini RN, Taylor PC: Systemic anti-tumor necrosis factor alpha therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor alpha synthesis. Arthritis Rheum. 2000, 43: 2391-2396. 10.1002/1529-0131(200011)43:11<2391::AID-ANR3>3.0.CO;2-F.
Article
CAS
PubMed
Google Scholar
Schotte H, Schluter B, Willeke P, Mickholz E, Schorat MA, Domschke W, Gaubitz M: Long-term treatment with etanercept significantly reduces the number of proinflammatory cytokine-secreting peripheral blood mononuclear cells in patients with rheumatoid arthritis. Rheumatology (Oxford). 2004, 43: 960-964. 10.1093/rheumatology/keh178.
Article
CAS
PubMed
Google Scholar
Drynda S, Kuhne C, Kekow J: Soluble tumour necrosis factor receptor treatment does not affect raised transforming growth factor beta levels in rheumatoid arthritis. Ann Rheum Dis. 2002, 61: 254-256. 10.1136/ard.61.3.254.
Article
PubMed Central
CAS
PubMed
Google Scholar
Catrina AI, Lampa J, Ernestam S, af Klint E, Bratt J, Klareskog L, Ulfgren AK: Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis. Rheumatology. 2002, 41: 484-489. 10.1093/rheumatology/41.5.484.
Article
CAS
PubMed
Google Scholar
Pouw Kraan van der TC, van Gaalen FA, Kasperkovitz PV, Verbeet NL, Smeets TJ, Kraan MC: Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum. 2003, 48: 2132-2145. 10.1002/art.11096.
Article
PubMed
Google Scholar
Glocker MO, Guthke R, Kekow J, Thiesen HJ: Rheumatoid arthritis, a complex multifactorial disease: on the way toward individualized medicine. Med Res Rev. 2006, 26: 63-87. 10.1002/med.20045.
Article
CAS
PubMed
Google Scholar
Lequerre T, Gauthier-Jauneau AC, Bansard C, Derambure C, Hiron M, Vittecoq O, Daveau M, Mejjad O, Daragon A, Tron F, Le Loët X, Salier JP: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. Arthritis Res Ther. 2006, 8: R105-10.1186/ar1924.
Article
PubMed Central
PubMed
Google Scholar
Lindberg J, af Klint E, Catrina AI, Nilsson P, Klareskog L, Ulfgren AK, Lundeberg J: Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients. Arthritis Res Ther. 2006, 8: R179-10.1186/ar2090.
Article
PubMed Central
PubMed
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002/art.1780310302.
Article
CAS
PubMed
Google Scholar
Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, Putte van de LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 44-48. 10.1002/art.1780380107.
Article
CAS
PubMed
Google Scholar
Boyum A: Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol. 1976, 9-15. Suppl 5
ArrayExpress. [http://www.ebi.ac.uk/arrayexpress-old/]
Thiesen HJ, Glocker MO, Guthke R, Kekow J: Patent PCT/EP03/05701. 30 May 2003
van Boekel MA, Vossenaar ER, Hoogen van den FH, van Venrooij WJ: Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res. 2002, 4: 87-93. 10.1186/ar395.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kishimoto T: Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther. 2006, 8 (Suppl 2): S2-10.1186/ar1916.
Article
PubMed Central
PubMed
Google Scholar
Maini RN, Taylor PC, Szechinski J, Pavelka K, Broll J, Balint G, Emery P, Raemen F, Petersen J, Smolen J, Thomson D, Kishimoto T, CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 2006, 54: 2817-2829. 10.1002/art.22033.
Article
CAS
PubMed
Google Scholar
Spielman RS, Bastone LA, Burdick JT, Morley M, Ewens WJ, Cheung VG: Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet. 2007, 39: 226-231. 10.1038/ng1955.
Article
PubMed Central
CAS
PubMed
Google Scholar