Tebib J, Mariette X, Bourgeois P, Flipo RM, Gaudin P, Le Loet X, Gineste P, Guy L, Mansfield CD, Moussy A, Dubreuil P, Hermine O, Sibilia J: Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res Ther. 2009, 11: R95-10.1186/ar2740.
Article
PubMed Central
PubMed
Google Scholar
Hahn KA, Ogilvie G, Rusk T, Devauchelle P, Leblanc A, Legendre A, Powers B, Leventhal PS, Kinet JP, Palmerini F, Dubreuil P, Moussy A, Hermine O: Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med. 2008, 22: 1301-1309. 10.1111/j.1939-1676.2008.0190.x.
Article
CAS
PubMed
Google Scholar
Sandler C, Joutsiniemi S, Lindstedt KA, Juutilainen T, Kovanen PT, Eklund KK: Imatinib mesylate inhibits platelet derived growth factor stimulated proliferation of rheumatoid synovial fibroblasts. Biochem Biophys Res Commun. 2006, 347: 31-35. 10.1016/j.bbrc.2006.06.052.
Article
CAS
PubMed
Google Scholar
Ando W, Hashimoto J, Nampei A, Tsuboi H, Tateishi K, Ono T, Nakamura N, Ochi T, Yoshikawa H: Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA). J Bone Miner Metab. 2006, 24: 274-282. 10.1007/s00774-006-0684-1.
Article
CAS
PubMed
Google Scholar
Paniagua RT, Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH: Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. J Clin Invest. 2006, 116: 2633-2642.
Article
PubMed Central
CAS
PubMed
Google Scholar
Juurikivi A, Sandler C, Lindstedt KA, Kovanen PT, Juutilainen T, Leskinen MJ, Maki T, Eklund KK: Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann Rheum Dis. 2005, 64: 1126-1131. 10.1136/ard.2004.029835.
Article
PubMed Central
CAS
PubMed
Google Scholar
Eklund KK: Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy. Immunol Rev. 2007, 217: 38-52. 10.1111/j.1600-065X.2007.00504.x.
Article
CAS
PubMed
Google Scholar
Eklund KK, Joensuu H: Treatment of rheumatoid arthritis with imatinib mesylate: clinical improvement in three refractory cases. Ann Med. 2003, 35: 362-367. 10.1080/07853890310001339.
Article
CAS
PubMed
Google Scholar
A Study of Imatinib 400 Mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis. [http://www.clinicaltrials.gov/ct2/show/NCT00154336?term=NCT00154336&rank=1]
Beckett EA, Ro S, Bayguinov Y, Sanders KM, Ward SM: Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn. 2007, 236: 60-72. 10.1002/dvdy.20929.
Article
CAS
PubMed
Google Scholar
Nurmio M, Kallio J, Toppari J, Jahnukainen K: Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis. Reprod Toxicol. 2008, 25: 442-446. 10.1016/j.reprotox.2008.03.004.
Article
CAS
PubMed
Google Scholar
Christopoulos C, Dimakopoulou V, Rotas E: Primary ovarian insufficiency associated with imatinib therapy. N Engl J Med. 2008, 358: 1079-1080. 10.1056/NEJMc0707841.
Article
CAS
PubMed
Google Scholar
Pye SM, Cortes J, Ault P, Hatfield A, Kantarjian H, Pilot R, Rosti G, Apperley JF: The effects of imatinib on pregnancy outcome. Blood. 2008, 111: 5505-5508. 10.1182/blood-2007-10-114900.
Article
CAS
PubMed
Google Scholar