Skip to main content
Download PDF

Erratum to: The role of X-chromosome inactivation in female predisposition to autoimmunity

Arthritis Research & Therapy volume 3, Article number: E001 (2001) Cite this article

The Original Article was published on 03 July 2000

Erratum

It has come to our attention that we overlooked a previous publication in the course ofdiscussing our work (cited above) on X chromosome inactivation and autoimmunity. Weproposed a model that is very similar to one put forward in 1977 by Richard Kast [1]. Thecentral concept is that X inactivation patterns in a tolerizing compartment, such as thethymus, may differ from those in the periphery, and this may predispose females toadditional risk of autoimmunity. Presumably the loss of tolerance due to this mechanism willbe directed at, or initiated by, polymorphic X-linked autoantigens. Our data neither confirmnor definitively refute this idea, and it will be challenging to develop experimental supportfor this hypothesis. In any case, we apologize for the oversight in not citing Dr Kast'sprevious publication.

References

  1. Kast RE: Predominance of autoimmune and rheumatic diseases in females. J Rheumatol. 1977, 4: 288-292.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. North Shore University Hospital, Manhasset, New York, USA

    Smita Chitnis, Joanita Monteiro & Peter K Gregersen

  2. Children's Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    David Glass

  3. New York Hospital/Cornell University Medical Center, New York, USA

    Brian Apatoff

  4. Weill Medical College of Cornell University and Hospital for Special Surgery, New York, USA

    Jane Salmon

  5. Virginia Mason Research Center, Seattle, Washington, USA

    Patrick Concannon

Authors
  1. Smita Chitnis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joanita Monteiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Glass
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Brian Apatoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jane Salmon
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Patrick Concannon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Peter K Gregersen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter K Gregersen.

Additional information

The online version of the original article can be found at 10.1186/ar118

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chitnis, S., Monteiro, J., Glass, D. et al. Erratum to: The role of X-chromosome inactivation in female predisposition to autoimmunity. Arthritis Res Ther 3, E001 (2001). https://doi.org/10.1186/ar298

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/ar298

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us