Skip to main content


  • Erratum
  • Open Access

Erratum to: The role of X-chromosome inactivation in female predisposition to autoimmunity

  • 1,
  • 1,
  • 2,
  • 3,
  • 4,
  • 5 and
  • 1Email author
Arthritis Research & Therapy20013:E001

  • Published:

The original article was published in Arthritis Research & Therapy 2000 2:399


It has come to our attention that we overlooked a previous publication in the course ofdiscussing our work (cited above) on X chromosome inactivation and autoimmunity. Weproposed a model that is very similar to one put forward in 1977 by Richard Kast [1]. Thecentral concept is that X inactivation patterns in a tolerizing compartment, such as thethymus, may differ from those in the periphery, and this may predispose females toadditional risk of autoimmunity. Presumably the loss of tolerance due to this mechanism willbe directed at, or initiated by, polymorphic X-linked autoantigens. Our data neither confirmnor definitively refute this idea, and it will be challenging to develop experimental supportfor this hypothesis. In any case, we apologize for the oversight in not citing Dr Kast'sprevious publication.


Authors’ Affiliations

North Shore University Hospital, Manhasset, New York, USA
Children's Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
New York Hospital/Cornell University Medical Center, New York, USA
Weill Medical College of Cornell University and Hospital for Special Surgery, New York, USA
Virginia Mason Research Center, Seattle, Washington, USA


  1. Kast RE: Predominance of autoimmune and rheumatic diseases in females. J Rheumatol. 1977, 4: 288-292.PubMedGoogle Scholar


© Biomed Central Ltd 2001