Erratum to: The role of X-chromosome inactivation in female predisposition to autoimmunity
© Biomed Central Ltd 2001
Published: 26 March 2001
The original article was published in Arthritis Research & Therapy 2000 2:399
It has come to our attention that we overlooked a previous publication in the course ofdiscussing our work (cited above) on X chromosome inactivation and autoimmunity. Weproposed a model that is very similar to one put forward in 1977 by Richard Kast . Thecentral concept is that X inactivation patterns in a tolerizing compartment, such as thethymus, may differ from those in the periphery, and this may predispose females toadditional risk of autoimmunity. Presumably the loss of tolerance due to this mechanism willbe directed at, or initiated by, polymorphic X-linked autoantigens. Our data neither confirmnor definitively refute this idea, and it will be challenging to develop experimental supportfor this hypothesis. In any case, we apologize for the oversight in not citing Dr Kast'sprevious publication.