The outline of this book follows a logical line of reasoning from genes (human and animal) to human leukocyte antigens (HLAs) to T cells, to joint-specific processes such as homing of inflammatory cells in the synovium, to synoviocytes. Although this outline makes the book very pleasant to read, the outline leads to a lot of overlapping data, repeatedly presented in the various chapters. The chapters on T cells are by themselves beautiful masterpieces, but it is disturbing that a chapter on dendritic cells and the crosstalk between T cells and dendritic cells in regulation of T-cell reactivity is lacking. Interestingly, the index lacked subjects such as "proteoglycans", "OPG" (osteoprotegerin) and "RANK" (receptor activator of NF-κB). The last part of the book, on "the role of TNF in rheumatoid arthritis" and "biologics in the treatment of rheumatoid arthritis", shows overlap as well, although the different perspectives presented in the various chapters provide the reader with a balanced view in this field.