Erratum to: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study

Sarah Djabarouti; Dominique Breilh; Pierre Duffau; Estibaliz Lazaro; Carine Greib; Olivier Caubet; Marie-Claude Saux; Jean-Luc Pellegrin; Jean-François Viallard

doi:10.1186/ar3265

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Erratum to: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study

Sarah Djabarouti¹Email author,
Dominique Breilh¹,
Pierre Duffau²,
Estibaliz Lazaro²,
Carine Greib²,
Olivier Caubet²,
Marie-Claude Saux¹,
Jean-Luc Pellegrin² and
Jean-François Viallard²

Arthritis Research & Therapy201113:401

https://doi.org/10.1186/ar3265

Published: 03 March 2011

The original article was published in Arthritis Research & Therapy 2010 12:R217

After publication of our recent article [1], we noticed an error in the unit for the area under the time-concentration curve between 0 and 12 hours (AUC_{0-12 h}). Throughout the article and Table 1 the unit should be mg·h/L (mg multiplied by hour per L) not mg/hour/L.

Table 1

Inclusion characteristics (of the 26 systemic lupus erythematosus patients) and their ability to predict clinical outcome (univariate analysis)

	Total	Successes	Failures
Inclusion characteristic	n= 26	n= 17	n= 8	Pvalue^a
Demographic
Females/Males, number	16/10	12/5	4/4	0.28^b
Age, years	46 (35-61)^a	46.5 (35-61)	46 (38-61)	0.9
Body weight, kg	60 (56-75)	60 (56-75)	62 (58-82.5)	0.62
Disease
Duration before entry, months	11 (7-14)	11 (7-12)	10 (6-13)	0.30
SLEDAI score	0 (0-2)	0 (0-2)	0 (0-2)	0.20
C3, g/L	1 (0.6-1.1)	1 (0.9-1.1)	0.8 (0.56-0.96)	0.21
C4, g/L	0.2 (0.1-0.2)	0.2 (0.1-0.2)	0.2 (0.16-0.24)	0.78
Anti-double-stranded DNA, IU/mL	24 (6-51)	8 (1-32)	38 (9-55)	0.19
Biological
GFR, mL/minute	95 (67-125)	95 (67-125)	93.5 (76-109)	0.64
Albumin, g/L	40 (39.8-43.8)	40 (37.9-43.8)	42.8 (40-46.9)	0.33
Aspartate aminotransferase, IU/L	23 (19-26)	23 (17.5-24.5)	28 (20-33)	0.26
Alanine aminotransferase, IU/L	22 (15-29)	19 (13-24.5)	25 (19-37)	0.21
γ-Glutamyltransferase, IU/L	24 (17-63)	23 (17-21)	42 (17-61)	0.92
Treatment
MMF, g/day	2 (2-2)	2 (2-2)	2 (2-2)	0.9
Corticosteroids, mg/day	11 (7-35)	10 (5-20)	15 (7-45)	0.37
Months of MMF therapy	2 (1-3)	2 (1-3)	2 (1-3)	0.56
Months of corticosteroids	10 (6-13)	10 (5-15)	9 (5-14)	0.12
MPA pharmacokinetic parameters
AUC_{0-12 h'} mg·hour/L	64.7 (38.2-82)	73.1 (61.8-95)	37.7 (32-43.7)	0.003
C_max' mg/L	16.1 (9.5-18.5)	16.3 (9.7-17.4)	13.3 (7-22.5)	0.69
T_max' hours	1 (1-2)	1 (1-2)	1.1 (1-2)	0.82
C_{12 h'} mg/L	2.4 (1.5-4.1)	3.7 (2.3-4.9)	1.5 (0.6-2.1)	0.008
MPAG pharmacokinetic parameters
AUC_{0-12 h'} mg·hour/L	775.3 (475-1,026)	791 (635-1,166)	678.8 (426-840.6)	0.22
T_max' hours	2 (2-3)	2.3 (2-3)	1.3 (1-2)	0.01
C_{12 h'} mg/L	32.1 (24.3-41.9)	34.7 (26.4-49.2)	29.8 (15.5-40)	0.26
MPAG/MPA AUC_{0-12 h} ratio	11.5 (8.3-20.7)	10.9 (6.2-14.8)	18.7 (14.1-22.7)	0.07
MPAG/MPA C_{12 h} ratio	11.5 (6.8-17.3)	10.2 (6.3-15)	18.7 (11.5-47.2)	0.02

Values are expressed as median (interquartile range) unless stated otherwise. ^aMann-Whitney U test; ^bFisher exact test. AUC_{0-12 h'} area under the plasma concentration-versus-time curves for hours 0 to 12; C_{12 h'} 12-hour trough concentration; C_max' maximal concentration; GFR, glomerular filtration rate (estimated with the Cockcroft-Gault formula); MMF, mycophenolate mofetil; MPA, mycophenolic acid; MPAG, mycophenolic acid glucuronide; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; T_max' time to maximal concentration.

The correct table is given here as Table 1.

(2)

Service de Médecine Interne et des Maladies Infectieuses, Université Victor Segalen Bordeaux 2, Hôpital Haut-Lévêque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac Cedex, France

References

Djabarouti S, Breilh D, Duffau P, Lazaro E, Greib C, Caubet O, Saux MC, Pellegrin JL, Viallard JF: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study. Arthritis Res Ther. 2010, 12: R217-10.1186/ar3202.PubMed CentralView ArticlePubMedGoogle Scholar

Erratum to: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study

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