Open Access

Erratum to: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study

  • Sarah Djabarouti1Email author,
  • Dominique Breilh1,
  • Pierre Duffau2,
  • Estibaliz Lazaro2,
  • Carine Greib2,
  • Olivier Caubet2,
  • Marie-Claude Saux1,
  • Jean-Luc Pellegrin2 and
  • Jean-François Viallard2
Arthritis Research & Therapy201113:401

https://doi.org/10.1186/ar3265

Published: 03 March 2011

The original article was published in Arthritis Research & Therapy 2010 12:R217
After publication of our recent article [1], we noticed an error in the unit for the area under the time-concentration curve between 0 and 12 hours (AUC0-12 h). Throughout the article and Table 1 the unit should be mg·h/L (mg multiplied by hour per L) not mg/hour/L.
Table 1

Inclusion characteristics (of the 26 systemic lupus erythematosus patients) and their ability to predict clinical outcome (univariate analysis)

 

Total

Successes

Failures

 

Inclusion characteristic

n= 26

n= 17

n= 8

Pvaluea

Demographic

    

   Females/Males, number

16/10

12/5

4/4

0.28b

   Age, years

46 (35-61)a

46.5 (35-61)

46 (38-61)

0.9

   Body weight, kg

60 (56-75)

60 (56-75)

62 (58-82.5)

0.62

Disease

    

   Duration before entry, months

11 (7-14)

11 (7-12)

10 (6-13)

0.30

   SLEDAI score

0 (0-2)

0 (0-2)

0 (0-2)

0.20

   C3, g/L

1 (0.6-1.1)

1 (0.9-1.1)

0.8 (0.56-0.96)

0.21

   C4, g/L

0.2 (0.1-0.2)

0.2 (0.1-0.2)

0.2 (0.16-0.24)

0.78

   Anti-double-stranded DNA, IU/mL

24 (6-51)

8 (1-32)

38 (9-55)

0.19

Biological

    

   GFR, mL/minute

95 (67-125)

95 (67-125)

93.5 (76-109)

0.64

   Albumin, g/L

40 (39.8-43.8)

40 (37.9-43.8)

42.8 (40-46.9)

0.33

   Aspartate aminotransferase, IU/L

23 (19-26)

23 (17.5-24.5)

28 (20-33)

0.26

   Alanine aminotransferase, IU/L

22 (15-29)

19 (13-24.5)

25 (19-37)

0.21

   γ-Glutamyltransferase, IU/L

24 (17-63)

23 (17-21)

42 (17-61)

0.92

Treatment

    

   MMF, g/day

2 (2-2)

2 (2-2)

2 (2-2)

0.9

   Corticosteroids, mg/day

11 (7-35)

10 (5-20)

15 (7-45)

0.37

   Months of MMF therapy

2 (1-3)

2 (1-3)

2 (1-3)

0.56

   Months of corticosteroids

10 (6-13)

10 (5-15)

9 (5-14)

0.12

MPA pharmacokinetic parameters

    

   AUC0-12 h' mg·hour/L

64.7 (38.2-82)

73.1 (61.8-95)

37.7 (32-43.7)

0.003

   Cmax' mg/L

16.1 (9.5-18.5)

16.3 (9.7-17.4)

13.3 (7-22.5)

0.69

   Tmax' hours

1 (1-2)

1 (1-2)

1.1 (1-2)

0.82

   C12 h' mg/L

2.4 (1.5-4.1)

3.7 (2.3-4.9)

1.5 (0.6-2.1)

0.008

MPAG pharmacokinetic parameters

    

   AUC0-12 h' mg·hour/L

775.3 (475-1,026)

791 (635-1,166)

678.8 (426-840.6)

0.22

   Tmax' hours

2 (2-3)

2.3 (2-3)

1.3 (1-2)

0.01

   C12 h' mg/L

32.1 (24.3-41.9)

34.7 (26.4-49.2)

29.8 (15.5-40)

0.26

MPAG/MPA AUC0-12 h ratio

11.5 (8.3-20.7)

10.9 (6.2-14.8)

18.7 (14.1-22.7)

0.07

MPAG/MPA C12 h ratio

11.5 (6.8-17.3)

10.2 (6.3-15)

18.7 (11.5-47.2)

0.02

Values are expressed as median (interquartile range) unless stated otherwise. aMann-Whitney U test; bFisher exact test. AUC0-12 h' area under the plasma concentration-versus-time curves for hours 0 to 12; C12 h' 12-hour trough concentration; Cmax' maximal concentration; GFR, glomerular filtration rate (estimated with the Cockcroft-Gault formula); MMF, mycophenolate mofetil; MPA, mycophenolic acid; MPAG, mycophenolic acid glucuronide; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; Tmax' time to maximal concentration.

The correct table is given here as Table 1.

Notes

Declarations

Authors’ Affiliations

(1)
Laboratoire de Pharmacocinétique et Pharmacie Clinique EA2968, Université Victor Segalen Bordeaux 2, Hôpital Haut-Lévêque, CHU de Bordeaux, Avenue de Magellan
(2)
Service de Médecine Interne et des Maladies Infectieuses, Université Victor Segalen Bordeaux 2, Hôpital Haut-Lévêque, CHU de Bordeaux, Avenue de Magellan

References

  1. Djabarouti S, Breilh D, Duffau P, Lazaro E, Greib C, Caubet O, Saux MC, Pellegrin JL, Viallard JF: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study. Arthritis Res Ther. 2010, 12: R217-10.1186/ar3202.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© BioMed Central Ltd 2011

Advertisement