Linger RM, Keating AK, Earp HS, Graham DK: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res. 2008, 100: 35-83.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lemke G, Rothlin CV: Immunobiology of the TAM receptors. Nat Rev Immunol. 2008, 8: 327-336. 10.1038/nri2303.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hafizi S, Dahlback B: Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily. FEBS J. 2006, 273: 5231-5244. 10.1111/j.1742-4658.2006.05529.x.
Article
CAS
PubMed
Google Scholar
Hafizi S, Dahlback B: Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. Cytokine Growth Factor Rev. 2006, 17: 295-304. 10.1016/j.cytogfr.2006.04.004.
Article
CAS
PubMed
Google Scholar
Shao WH, Zhen Y, Eisenberg RA, Cohen PL: The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin Immunol. 2009, 133: 138-144. 10.1016/j.clim.2009.06.002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nandrot EF, Dufour EM: Mertk in daily retinal phagocytosis: a history in the making. Adv Exp Med Biol. 2010, 664: 133-140. 10.1007/978-1-4419-1399-9_16.
Article
CAS
PubMed
Google Scholar
Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007, 131: 1124-1136. 10.1016/j.cell.2007.10.034.
Article
CAS
PubMed
Google Scholar
Gregory CD, Devitt A: The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?. Immunology. 2004, 113: 1-14. 10.1111/j.1365-2567.2004.01959.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA: Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med. 2002, 196: 135-140. 10.1084/jem.20012094.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM, Graham DK: A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood. 2007, 109: 1026-1033.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ekman C, Stenhoff J, Dahlback B: Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J Thromb Haemost. 2010, 8: 838-844. 10.1111/j.1538-7836.2010.03752.x.
Article
CAS
PubMed
Google Scholar
Ekman C, Linder A, Akesson P, Dahlback B: Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes. Crit Care. 2010, 14: R158-10.1186/cc9233.
Article
PubMed Central
PubMed
Google Scholar
Ekman C, Jonsen A, Sturfelt G, Bengtsson AA, Dahlbäck B: Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus. Rheumatology (Oxford). 2011, 50: 1064-9. 10.1093/rheumatology/keq459.
Article
CAS
Google Scholar
Katsiari CG, Liossis SN, Sfikakis PP: The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal. Semin Arthritis Rheum. 2010, 39: 491-503. 10.1016/j.semarthrit.2008.11.002.
Article
CAS
PubMed
Google Scholar
Brown KD, Claudio E, Siebenlist U: The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res Ther. 2008, 10: 212-10.1186/ar2457.
Article
PubMed Central
PubMed
Google Scholar
Minar E: Critical limb ischaemia. Hamostaseologie. 2009, 29: 102-109.
CAS
PubMed
Google Scholar
Novo S, Coppola G, Milio G: Critical limb ischemia: definition and natural history. Curr Drug Targets Cardiovasc Haematol Disord. 2004, 4: 219-225. 10.2174/1568006043335989.
Article
CAS
PubMed
Google Scholar
Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982, 25: 1271-1277. 10.1002/art.1780251101.
Article
CAS
PubMed
Google Scholar
Lindqvist E, Saxne T, Geborek P, Eberhardt K: Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage. Ann Rheum Dis. 2002, 61: 1055-1059. 10.1136/ard.61.12.1055.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lindqvist E, Jonsson K, Saxne T, Eberhardt K: Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis. Ann Rheum Dis. 2003, 62: 611-616. 10.1136/ard.62.7.611.
Article
PubMed Central
CAS
PubMed
Google Scholar
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG: Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007, 45: S5-S67. 10.1016/j.jvs.2006.12.037.
Article
PubMed
Google Scholar
Barani J, Nilsson JA, Mattiasson I, Lindblad B, Gottsater A: Inflammatory mediators are associated with 1-year mortality in critical limb ischemia. J Vasc Surg. 2005, 42: 75-80. 10.1016/j.jvs.2005.03.025.
Article
PubMed
Google Scholar
Nagata S, Hanayama R, Kawane K: Autoimmunity and the clearance of dead cells. Cell. 2010, 140: 619-630. 10.1016/j.cell.2010.02.014.
Article
CAS
PubMed
Google Scholar
Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, Neuhuber WL, Kirchner T, Kalden JR, Herrmann M: Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 2002, 46: 191-201. 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K.
Article
PubMed
Google Scholar
Munoz LE, Lauber K, Schiller M, Manfredi AA, Herrmann M: The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol. 2010, 6: 280-289. 10.1038/nrrheum.2010.46.
Article
PubMed
Google Scholar
Munoz LE, Gaipl US, Franz S, Sheriff A, Voll RE, Kalden JR, Herrmann M: SLE--a disease of clearance deficiency?. Rheumatology (Oxford). 2005, 44: 1101-1107. 10.1093/rheumatology/keh693.
Article
CAS
Google Scholar
Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR: Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum. 1998, 41: 1241-1250. 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H.
Article
CAS
PubMed
Google Scholar
Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK: Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature. 2001, 411: 207-211. 10.1038/35075603.
Article
CAS
PubMed
Google Scholar
Seitz HM, Camenisch TD, Lemke G, Earp HS, Matsushima GK: Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol. 2007, 178: 5635-5642.
Article
CAS
PubMed
Google Scholar
Wu Y, Singh S, Georgescu MM, Birge RB: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci. 2005, 118: 539-553. 10.1242/jcs.01632.
Article
CAS
PubMed
Google Scholar
Todt JC, Hu B, Curtis JL: The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukoc Biol. 2008, 84: 510-518. 10.1189/jlb.0307135.
Article
PubMed Central
CAS
PubMed
Google Scholar
Alciato F, Sainaghi PP, Sola D, Castello L, Avanzi GC: TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J Leukoc Biol. 2010, 87: 869-875. 10.1189/jlb.0909610.
Article
CAS
PubMed
Google Scholar
Shao WH, Eisenberg RA, Cohen PL: The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol. 2008, 180: 7728-7735.
Article
CAS
PubMed
Google Scholar
Wallet MA, Sen P, Flores RR, Wang Y, Yi Z, Huang Y, Mathews CE, Earp HS, Matsushima G, Wang B, Tisch R: MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med. 2008, 205: 219-232. 10.1084/jem.20062293.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wallet MA, Flores RR, Wang Y, Yi Z, Kroger CJ, Mathews CE, Earp HS, Matsushima G, Wang B, Tisch R: MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci USA. 2009, 106: 4810-4815. 10.1073/pnas.0900683106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Banchereau J, Pascual V: Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity. 2006, 25: 383-392. 10.1016/j.immuni.2006.08.010.
Article
CAS
PubMed
Google Scholar
Pascual V, Farkas L, Banchereau J: Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol. 2006, 18: 676-682. 10.1016/j.coi.2006.09.014.
Article
CAS
PubMed
Google Scholar
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Diaz M, Gallardo G, De Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A: Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009, 31: 245-258. 10.1016/j.immuni.2009.06.018.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chaussabel D, Quinn C, Shen J, Patel P, Glaser C, Baldwin N, Stichweh D, Blankenship D, Li L, Munagala I, Bennett L, Allantaz F, Mejias A, Ardura M, Kaizer E, Monnet L, Allman W, Randall H, Johnson D, Lanier A, Punaro M, Wittkowski KM, White P, Fay J, Klintmalm G, Ramilo O, Palucka AK, Banchereau J, Pascual V: A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008, 29: 150-164. 10.1016/j.immuni.2008.05.012.
Article
PubMed Central
CAS
PubMed
Google Scholar
Prasad D, Rothlin CV, Burrola P, Burstyn-Cohen T, Lu Q, Garcia FP, Lemke G: TAM receptor function in the retinal pigment epithelium. Mol Cell Neurosci. 2006, 33: 96-108. 10.1016/j.mcn.2006.06.011.
Article
CAS
PubMed
Google Scholar
Brea-Fernandez AJ, Pomares E, Brion MJ, Marfany G, Blanco MJ, Sanchez-Salorio M, Gonzalez-Duarte R, Carracedo A: Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. Br J Ophthalmol. 2008, 92: 1419-1423. 10.1136/bjo.2008.139204.
Article
CAS
PubMed
Google Scholar
Ekman C, Gottsater A, Lindblad B, Dahlback B: Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia. Clin Biochem. 2010, 43: 873-876. 10.1016/j.clinbiochem.2010.04.006.
Article
CAS
PubMed
Google Scholar
Castellano G, Trouw LA, Fiore N, Daha MR, Schena FP, van Kooten C: Infiltrating dendritic cells contribute to local synthesis of C1q in murine and human lupus nephritis. Mol Immunol. 2010, 47: 2129-2137. 10.1016/j.molimm.2010.02.006.
Article
CAS
PubMed
Google Scholar
Alzawawy A, Zohary M, Ablordiny M, Eldalie M: Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. Int J Rheum Dis. 2009, 12: 311-318. 10.1111/j.1756-185X.2009.01429.x.
Article
PubMed
Google Scholar