Skip to main content
  • Poster presentation
  • Open access
  • Published:

Adrenal function in rheumatoid arthritis: a correlation with disease activity


Hypothalamic-pituitary-adrenocortical dysfunction contributes to a complex pathogenesis of rheumatoid arthritis (RA). Decreased production of adrenal androgens and subtle changes in cortisol production has been observed in RA, particularly in female patients with premenopausal onset of the disease. Our study was aimed to investigate (1) adrenocortical function in relation to disease and inflammatory activity and to analyze cortisol bioavailability in RA females.

Materials and methods

Adrenal steroids including free plasma cortisol responses to the low-dose ACTH stimulation test (1 µg Synactheni.v.) were investigated in 23 premenopausal RA and in 15 age- and BMI-matched healthy females. Twelve (N = 12) out of 23 RA patients were on low-dose glucocorticoids (<8.5 mg/day of prednisone or equivalent). When patients were divided into low (disease activity score 28; DAS28≤ 3.2) and moderate to high disease activity (DAS28>3.2) subgroups, glucocorticoid-treated patients comprised 53% and 50% of patients in each of the subgroups. Plasma C-reactive protein, interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-17, interferon gamma and tumor necrosis factor alpha concentrations were measured at the baseline.


RA patients had high C-reactive protein, IL-6, IL-8 and tumor necrosis factor alpha. Patients with DAS28>3.2 had lower (p < 0.05) total plasma cortisol, 17-hydroxyprogesterone, dehydroepiandrosterone and androstenedione responses in the ACTH test compared to healthy controls. Patients with DAS28>3.2 had lower (p < 0.05) dehydroepiandrosterone response in the ACTH test compared to patients with DAS28≤ 3.2. C-reactive protein (CRP), DAS28, and interleukin (IL)-6 negatively correlated with androstenedione response to Synacthen. Responses of all measured adrenal steroids were lower (p < 0.05) in patients on low-dose glucocorticoids compared to healthy controls. RA patients not treated with glucocorticoids had lower total cortisol response (p = 0.038) compared to controls, however, these patients did not differ in free plasma cortisol in the ACTH test.


The present data indicate an association of increased disease activity with a decrease in adrenal androgen-producing zonareticularis in RA. A modest suppression of stimulated cortisol in glucocorticoid-untreated RA patients is not associated with decreased cortisol bioavailability.

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

Imrich, R., Vlcek, M., Kerlik, J. et al. Adrenal function in rheumatoid arthritis: a correlation with disease activity. Arthritis Res Ther 14 (Suppl 1), P27 (2012).

Download citation

  • Published:

  • DOI: