Objective
Rheumatoid arthritis (RA) is an autoimmune arthritis for which treatment options remain limited. Pathogenic mechanisms of RA and its animal model collagen-induced arthritis (CIA) involve joint infiltration by pro-inflammatory T-helper 1 (Thl) type CD4+ T cells. This study investigated the potentiel use of retrovirally transduced collagen type II (CII)-reactive CD4+ T cells for local delivery of an anti-inflammatory cytokine, interleukin 4 (IL-4), to inflamed joints.