Objective
The use, via electro-permeabilization (electroporation), of 'chondroprotective' genes may provide a powerful set of tools applicable to the development of plasmid-based gene therapies for OA process. To assess whether permeabilizing drug pulses may overcome the barrier-effect of peri-cellular matrix environment, we investigated the efficiency of plasmid delivery by electroporation and the subsequent duration of transgene expression (GFP and Hsp-70) in rat patellar cartilage.