Takeuchi M, Hokama H, Tsukahara R, Kezuka T, Goto H, Sakai J, Usui M: Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement. Graefes Arch Clin Exp Ophthalmol. 2005, 243: 1147-1152. 10.1007/s00417-005-0005-8.
Article
PubMed
Google Scholar
Raziuddin S, al-Dalaan A, Bahabri S, Siraj AK, al-Sedairy S: Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol. 1998, 25: 329-333.
CAS
PubMed
Google Scholar
Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K: Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand J Rheumatol. 2002, 31: 205-210. 10.1080/030097402320318387.
Article
PubMed
Google Scholar
Hamzaoui K, Bouali E, Ghorbel I, Khanfir M, Houman H, Hamzaoui A: Expression of Th-17 and RORγt mRNA in Behçet's Disease. Med Sci Monit. 2011, 17: 227-234.
Article
Google Scholar
Takeuchi M, Usui Y, Okunuki Y, Zhang L, Ma J, Yamakawa N, Hattori T, Kezuka T, Sakai J, Goto H: Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis. Invest Ophthalmol Vis Sci. 2010, 51: 3067-3075. 10.1167/iovs.09-4313.
Article
PubMed
Google Scholar
Chi W, Zhu X, Yang P, Liu X, Lin X, Zhou H, Huang X, Kijlstra A: Upregulated IL-23 and IL-17 in Behçet patients with active uveitis. Invest Ophthalmol Vis Sci. 2008, 49: 3058-3064. 10.1167/iovs.07-1390.
Article
PubMed
Google Scholar
Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H: Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet. 2010, 42: 703-706. 10.1038/ng.624.
Article
CAS
PubMed
Google Scholar
Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, et al: Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet. 2010, 42: 698-702. 10.1038/ng.625.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ohno S, Nakamura S, Hori S, Shimakawa M, Kawashima H, Mochizuki M, Sugita S, Ueno S, Yoshizaki K, Inaba G: Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Behcet's disease with refractory uveoretinitis. J Rheumatol. 2004, 31: 1362-1368.
CAS
PubMed
Google Scholar
Sfikakis PP, Theodossiadis PG, Katsiari CG, Kaklamanis P, Markomichelakis NN: Effect of infliximab on sight-threatening panuveitis in Behcet's disease. Lancet. 2001, 358: 295-296. 10.1016/S0140-6736(01)05497-6.
Article
CAS
PubMed
Google Scholar
Munoz-Fernandez S, Hidalgo V, Fernandez-Melon J, Schlincker A, Martín-Mola E: Effect of infliximab on threatening panuveitis in Behcet's disease. Lancet. 2001, 358: 1644-
Article
CAS
PubMed
Google Scholar
Tugal-Tutkun I, Mudun A, Urgancioglu M, Kamali S, Kasapoglu E, Inanc M, Gül A: Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behcet's disease: an open-label trial. Arthritis Rheum. 2005, 52: 2478-2484. 10.1002/art.21231.
Article
CAS
PubMed
Google Scholar
Tabbara KF, Al-Hemidan AI: Infliximab effects compared to conventional therapy in the management of retinal vasculitis in Behcet disease. Am J Ophthalmol. 2008, 146: 845-850. 10.1016/j.ajo.2008.09.010.
Article
CAS
PubMed
Google Scholar
Yamada Y, Sugita S, Tanaka H, Kamoi K, Kawaguchi T, Mochizuki M: Comparison of infliximab versus cyclosporine during the initial 6-month treatment period in Behcet's disease. Br J Ophthalmol. 2010, 94: 284-288. 10.1136/bjo.2009.158840.
Article
PubMed
Google Scholar
Yamada Y, Sugita S, Tanaka H, Kamoi K, Takase H, Mochizuki M: Timing of recurrent uveitis in patients with Behcet's disease receiving infliximab treatment. Br J Ophthalmol. 2011, 95: 205-208. 10.1136/bjo.2009.168856.
Article
PubMed
Google Scholar
Sugita S, Yamada Y, Mochizuki M: Relationship between serum infliximab levels and acute uveitis attacks in patients with Behçet's disease. Br J Ophthalmol. 2011, 95: 549-552. 10.1136/bjo.2009.174888.
Article
PubMed
Google Scholar
Sugita S, Yamada Y, Kaneko S, Horie S, Mochizuki M: Induction of regulatory T cells by infliximab in Behçet's disease. Invest Ophthalmol Vis Sci. 2011, 52: 476-484. 10.1167/iovs.10-5916.
Article
CAS
PubMed
Google Scholar
Behcet's Disease Research Committee of Japan: Behcet's disease: guide to diagnosis of Behcet's disease. Jpn J Ophthalmol. 1974, 18: 291-294.
Google Scholar
Sugita S, Usui Y, Horie S, Futagami Y, Aburatani H, Okazaki T, Honjo T, Takeuchi M, Mochizuki M: T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest Ophthalmol Vis Sci. 2009, 50: 2862-2870. 10.1167/iovs.08-2846.
Article
PubMed
Google Scholar
Caspi RR, Roberge FG, Chan CC, Wiggert B, Chader GJ, Rozenszajn LA, Lando Z, Nussenblatt RB: A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol. 1988, 140: 1490-1495.
CAS
PubMed
Google Scholar
Thurau SR, Chan CC, Nussenblatt RB, Caspi RR: Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin Exp Immunol. 1997, 109: 370-376. 10.1046/j.1365-2249.1997.4571356.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR: Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000, 41: 127-131.
CAS
PubMed
Google Scholar
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006, 441: 235-238. 10.1038/nature04753.
Article
CAS
PubMed
Google Scholar
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006, 24: 179-189. 10.1016/j.immuni.2006.01.001.
Article
CAS
PubMed
Google Scholar
Korn T, Bettelli E, Oukka M, Kuchroo VK: IL-17 and Th17 Cells. Annu Rev Immunol. 2009, 27: 485-517. 10.1146/annurev.immunol.021908.132710.
Article
CAS
PubMed
Google Scholar
Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE: TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med. 2007, 13: 711-718. 10.1038/nm1585.
Article
CAS
PubMed
Google Scholar
Chi W, Yang P, Li B, Wu C, Jin H, Zhu X, Chen L, Zhou H, Huang X, Kijlstra A: IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immuno. 2007, 119: 1218-1224. 10.1016/j.jaci.2007.01.010.
Article
CAS
Google Scholar
Yoshimura T, Sonoda KH, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, Yoshida H: Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis. Int Immunol. 2008, 20: 209-214.
Article
CAS
PubMed
Google Scholar
Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A: Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford). 2009, 48: 347-354. 10.1093/rheumatology/ken489.
Article
CAS
Google Scholar
Cui Y, Shao H, Lan C, Nian H, O'Brien RL, Born WK, Kaplan HJ, Sun D: Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells. J Immunol. 2009, 183: 560-567. 10.4049/jimmunol.0900241.
Article
PubMed Central
CAS
PubMed
Google Scholar
Medvedev A, Chistokhina A, Hirose T, Jetten AM: Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. Genomics. 1997, 46: 93-102. 10.1006/geno.1997.4980.
Article
CAS
PubMed
Google Scholar
He YW, Deftos ML, Ojala EW, Bevan MJ: RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity. 1998, 9: 797-806. 10.1016/S1074-7613(00)80645-7.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sartani G, Silver PB, Rizzo LV, Chan CC, Wiggert B, Mastorakos G, Caspi RR: Anti-tumor necrosis factor alpha therapy suppresses the induction of experimental autoimmune uveoretinitis in mice by inhibiting antigen priming. Invest Ophthalmol Vis Sci. 1996, 37: 2211-2218.
CAS
PubMed
Google Scholar
Ziegler SF, Buckner JH: FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 2009, 11: 594-598. 10.1016/j.micinf.2009.04.002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE: TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood. 2006, 108: 253-261. 10.1182/blood-2005-11-4567.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nadkarni S, Mauri C, Ehrenstein MR: Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med. 2007, 204: 33-39. 10.1084/jem.20061531.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hamzaoui K: Th17 cells in Behçet's disease: a new immunoregulatory axis. Clin Exp Rheumatol. 2011, 29: 71-76.
Google Scholar
Hamzaoui K, Borhani Haghighi A, Ghorbel IB, Houman H: RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behçet's disease. J Neuroimmunol. 2011, 233: 249-453. 10.1016/j.jneuroim.2011.01.012.
Article
CAS
PubMed
Google Scholar
Nakamura S, Sugita M, Tanaka T, Tanaka S, Isoda F, Ohno S: In vitro tumor necrosis factor-alpha producibility in peripheral monocytes in patients with Behcet's disease. Nippon Ganka Gakkai Zasshi. 1992, 96: 1282-1285.
CAS
PubMed
Google Scholar
Sakaguchi M, Sugita S, Sagawa K, Itoh K, Mochizuki M: Cytokine production by T cells infiltrating in the eye of uveitis patients. Jpn J Ophthalmol. 1998, 42: 262-268. 10.1016/S0021-5155(98)00016-1.
Article
CAS
PubMed
Google Scholar
Sugita S, Takase H, Taguchi C, Mochizuki M: The role of soluble TNF receptors for TNF-α in uveitis. Invest Ophthalmol Vis Sci. 2007, 48: 3246-3252. 10.1167/iovs.06-1444.
Article
PubMed
Google Scholar
Zhang R, Qian J, Guo J, Yuan YF, Xue K: Suppression of experimental autoimmune uveoretinitis by anti-IL-17 antibody. Curr Eye Res. 2009, 34: 297-303. 10.1080/02713680902741696.
Article
PubMed
Google Scholar