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Table 5 Haplotype analysis of ERAP 1 SNPs in 797 AS patients and 1150 normal controls.

From: ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

Associated haplotypes

Frequency

EM algorithm*

Logistic regression

Logistic regression

(rs27037 + rs27980 + rs27044)

AS

Normal

P -value

P -value

OR (95% CI)

(sex adjusted)

      

P -value

OR (95% CI)

GCC

0.085

0.119

9 × 10-3

7 × 10-4

0.69 (0.55-0.85)

1.9 × 10-3

0.69 (0.55-0.87)

TAG

0.008

0.012

2.6 × 10-3

3.9 × 10-3

0.21 (0.07-0.61)

4.3 × 10-3

0.21 (0.07-0.61)

TCG

0.475

0.399

<0.00001

<0.00001

1.36 (1.12-1.55)

<0.00001

1.38 (1.12-1.58)

  1. *The p-values for the estimated haplotypes were generated from 10,000 permutations.
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Arthritis Research & Therapy

ISSN: 1478-6362

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