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Table 5 Haplotype analysis of ERAP 1 SNPs in 797 AS patients and 1150 normal controls.

From: ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

Associated haplotypes Frequency EM algorithm* Logistic regression Logistic regression
(rs27037 + rs27980 + rs27044) AS Normal P -value P -value OR (95% CI) (sex adjusted)
       P -value OR (95% CI)
GCC 0.085 0.119 9 × 10-3 7 × 10-4 0.69 (0.55-0.85) 1.9 × 10-3 0.69 (0.55-0.87)
TAG 0.008 0.012 2.6 × 10-3 3.9 × 10-3 0.21 (0.07-0.61) 4.3 × 10-3 0.21 (0.07-0.61)
TCG 0.475 0.399 <0.00001 <0.00001 1.36 (1.12-1.55) <0.00001 1.38 (1.12-1.58)
  1. *The p-values for the estimated haplotypes were generated from 10,000 permutations.