van der Linden SM, van der Heijde D, Maksymowych WP: Ankylosing spondylitis. Kelley's Textbook of Rheumatology. Edited by: Firestein GS, Budd RC, Harris ED Jr, McInnes IB, Ruddy S, Sergent JS. 2008, Philadelphia: Saunders-Elsevier, II: 1169-1190. 8
Google Scholar
Braun J, Sieper J: Ankylosing spondylitis. Lancet. 2007, 369: 1379-1390. 10.1016/S0140-6736(07)60635-7.
Article
PubMed
Google Scholar
Lories RJ, Luyten FP, de Vlam K: Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis. Arthritis Res Ther. 2009, 11: 221-10.1186/ar2642.
Article
PubMed Central
PubMed
Google Scholar
Tam LS, Gu J, Yu D: Pathogenesis of ankylosing spondylitis. Nat Rev Rheumatol. 2010, 6: 399-405. 10.1038/nrrheum.2010.79.
Article
PubMed
Google Scholar
Brown MA: Genetics and the pathogenesis of ankylosing spondylitis. Curr Opin Rheumatol. 2009, 21: 318-323. 10.1097/BOR.0b013e32832b3795.
Article
CAS
PubMed
Google Scholar
Said-Nahal R, Miceli-Richard C, Berthelot JM, Duché A, Dernis-Labous E, Le Blévec G, Saraux A, Perdriger A, Guis S, Claudepierre P, Sibilia J, Amor B, Dougados M, Breban M: The familial form of spondylarthropathy: a clinical study of 115 multiplex families. Arthritis Rheum. 2000, 43: 1356-1365. 10.1002/1529-0131(200006)43:6<1356::AID-ANR20>3.0.CO;2-Y.
Article
CAS
PubMed
Google Scholar
Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E, Shatford JL, Taylor A, Calin A, Wordsworth P: Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum. 1997, 40: 1823-1828. 10.1002/art.1780401015.
Article
CAS
PubMed
Google Scholar
Reveille JD: The genetic basis of spondyloarthritis. Ann Rheum Dis. 2011, 70 (Suppl 1): 44-50. 10.1136/ard.2010.140574.
Article
Google Scholar
Wellcome Trust CaseControl Consortium; Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, et al: Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007, 39: 1329-1337. 10.1038/ng.2007.17.
Article
Google Scholar
Australo-Anglo-American Spondyloarthritis Consortium(TASC), Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Appleton LH, Davis JC, Diekman L, Doan T, Dowling A, Duan R, Duncan EL, Farrar C, Hadler J, Harvey D, Karaderi T, Mogg R, Pomeroy E, Pryce K, Taylor J, Savage L, Deloukas P, Kumanduri V, Peltonen L, Ring SM, Whittaker P, et al: Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010, 42: 123-127. 10.1038/ng.513.
Article
Google Scholar
Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, Sturrock RD, Stone MA, Oppermann U, Brown MA, Wordsworth BP: Investigating the genetic association between ERAP1 and ankylosing spondylitis. Hum Mol Genet. 2009, 18: 4204-4212. 10.1093/hmg/ddp371.
Article
PubMed Central
CAS
PubMed
Google Scholar
Davidson SI, Wu X, Liu Y, Wei M, Danoy PA, Thomas G, Cai Q, Sun L, Duncan E, Wang N, Yu Q, Xu A, Fu Y, Brown MA, Xu H: Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum. 2009, 60: 3263-3268. 10.1002/art.24933.
Article
CAS
PubMed
Google Scholar
Saric T, Chang SC, Hattori AI, York IA, Markant SK, Rock KL, Tsujimoto M, Goldberg AL: An IFN gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol. 2002, 3: 1169-1176. 10.1038/ni859.
Article
CAS
PubMed
Google Scholar
York IA, Chang SC, Saric t, Keys A, Favreau JM, Goldberg AL, Rock KL: The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol. 2002, 3: 1177-1184. 10.1038/ni860.
Article
CAS
PubMed
Google Scholar
Hilton C, Kisselev AF, Rock KL, Goldberg AL: 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J. 2001, 20: 2357-2366. 10.1093/emboj/20.10.2357.
Article
PubMed Central
PubMed
Google Scholar
Rock KL, York IA, Goldberg AL: Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004, 5: 670-677. 10.1038/ni1089.
Article
CAS
PubMed
Google Scholar
Serwold T, Gonzalez F, Kim J, Jacob R, Shastri N: ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature. 2002, 419: 480-483. 10.1038/nature01074.
Article
CAS
PubMed
Google Scholar
Cui X, Hawari F, Alsaaty S, Lawrence M, Combs CA, Geng W, Rouhani FN, Miskinis D, Levine SJ: Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. J Clin Invest. 2002, 110: 515-526.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cui X, Rouhani FN, Hawari F, Levine SJ: An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding. J Biol Chem. 2003, 278: 28677-28685. 10.1074/jbc.M300456200.
Article
CAS
PubMed
Google Scholar
Cui X, Rouhani FN, Hawari F, Levine SJ: Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. J Immunol. 2003, 171: 6814-6819.
Article
CAS
PubMed
Google Scholar
Tsui FW, Haroon N, Reveille JD, Rahman P, Chiu B, Tsui HW, Inman RD: Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Ann Rheum Dis. 2010, 69: 733-736. 10.1136/ard.2008.103804.
Article
CAS
PubMed
Google Scholar
Choi CB, Kim TH, Jun JB, Lee HS, Shim SC, Lee B, Pope A, Uddin M, Rahman P, Inman RD: ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans. Ann Rheum Dis. 2010, 69: 582-584. 10.1136/ard.2008.105296.
Article
PubMed
Google Scholar
Davidson SI, Liu Y, Danoy PA, Wu X, Thomas GP, Jiang L, Sun L, Wang N, Han J, Han H, Australo-Anglo-American Spondyloarthritis Consortium, Visscher PM, Brown MA, Xu H: Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis. 2011, 70: 289-292. 10.1136/ard.2010.133322.
Article
CAS
PubMed
Google Scholar
Li C, Lin Z, Xie Y, Guo Z, Huang J, Wei Q, Li QX, Wang X, Cao S, Liao Z, Xu M, Shen Y, Gu J: ERAP1 is associated with ankylosing spondylitis in Han Chinese. J Rheumatol. 2011, 38: 317-321. 10.3899/jrheum.100013.
Article
CAS
PubMed
Google Scholar
Bang SY, Kim TH, Lee B, Kwon E, Choi SH, Lee KS, Shim SC, Pope A, Rahman P, Reveille JD, Inman RD: Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients. J Rheumatol. 2011, 38: 322-324. 10.3899/jrheum.100652.
Article
CAS
PubMed
Google Scholar
Pazár B, Sáfrány E, Gergely P, Szántó S, Szekanecz Z, Poór G: Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. J Rheumatol. 2010, 37: 379-384. 10.3899/jrheum.090806.
Article
PubMed
Google Scholar
van der Linden S, Valkenburg HA, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368. 10.1002/art.1780270401.
Article
CAS
PubMed
Google Scholar
Chen JY, Wang CM, Ma CC, Luo SF, Edberg JC, Kimberly RP, Wu J: Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. Arthritis Rheum. 2006, 54: 3908-3917. 10.1002/art.22220.
Article
CAS
PubMed
Google Scholar
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet. 2007, 81: 559-575. 10.1086/519795.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chang SC, Momburg F, Bhutani N, Goldberg AL: The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci USA. 2005, 102: 17107-17112. 10.1073/pnas.0500721102.
Article
PubMed Central
CAS
PubMed
Google Scholar
York IA, Brehm MA, Zendzian S, Towne CF, Rock KL: Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci USA. 2006, 103: 9202-9207. 10.1073/pnas.0603095103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Blanchard N, Kanaseki T, Escobar H, Delebecque F, Nagarajan NA, Reyes-Vargas E, Crockett DK, Raulet DH, Delgado JC, Shastri N: Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells. J Immunol. 2010, 184: 3033-3042. 10.4049/jimmunol.0903712.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N: The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol. 2006, 7: 103-112. 10.1038/ni1286.
Article
CAS
PubMed
Google Scholar
Hammer GE, Gonzalez F, James E, Nolla H, Shastri N: In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol. 2006, 8: 101-108.
Article
PubMed
Google Scholar
Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagomez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L: In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med. 2006, 203: 647-665. 10.1084/jem.20052271.
Article
PubMed Central
CAS
PubMed
Google Scholar
Firat E, Saveanu L, Aichele P, Staeheli P, Huai J, Gaedicke S, Nil A, Besin G, Kanzler B, van Endert P, Niedermann G: The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation. J Immunol. 2007, 178: 2241-2248.
Article
CAS
PubMed
Google Scholar
Campbell EC, Fettke F, Bhat S, Morley KD, Powis SJ: Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort. Immunology. 2011, 133: 379-385. 10.1111/j.1365-2567.2011.03453.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goto Y, Ogawa K, Hattori A, Tsujimoto M: Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon gamma. J Biol Chem. 2011, 286: 21906-21914. 10.1074/jbc.M111.239111.
Article
PubMed Central
CAS
PubMed
Google Scholar
Colbert RA, DeLay ML, Klenk EI, Layh-Schmitt G: From HLA-B27 to spondyloarthritis: a journey through the ER. Immunol Rev. 2010, 233: 181-202. 10.1111/j.0105-2896.2009.00865.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haroon N, Inman RD: Endoplasmic reticulum aminopeptidases: biology and pathogenic potential. Nat Rev Rheumatol. 2010, 6: 461-467. 10.1038/nrrheum.2010.85.
Article
CAS
PubMed
Google Scholar
Kanaseki T, Blanchard N, Hammer GE, Gonzalez F Shastri N: ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity. 2006, 25: 795-806. 10.1016/j.immuni.2006.09.012.
Article
PubMed Central
CAS
PubMed
Google Scholar
Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P, Spondyloarthritis Research Consortium of Canada (SPARCC), Morgan A, Marzo-Ortega H, Bowness P, et al: Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011, 43: 761-767. 10.1038/ng.873.
Article
PubMed Central
CAS
PubMed
Google Scholar
Baraliakos X, Listing J, Rudwaleit M, Haibel H, Brandt J, Sieper J, Braun J: Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes. Ann Rheum Dis. 2007, 66: 910-915. 10.1136/ard.2006.066415.
Article
PubMed Central
CAS
PubMed
Google Scholar
Baraliakos X, Listing J, Rudwaleit M, Sieper J, Braun J: The relationship between inflammation and new bone formation in patients with ankylosing spondylitis. Arthritis Res Ther. 2008, 10: R104-10.1186/ar2496.
Article
PubMed Central
PubMed
Google Scholar
Schett G: Joint remodelling in inflammatory disease. Ann Rheum Dis. 2007, 66 (Suppl 3): 42-44.
Google Scholar
Haroon N, Tsui FW, Chiu B, Tsui HW, Inman RD: Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms. J Rheumatol. 2010, 37: 1907-1910. 10.3899/jrheum.100019.
Article
CAS
PubMed
Google Scholar
Lories RJ, Derese I, Luyten FP: Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis. Rheumatology. 2008, 47: 605-608. 10.1093/rheumatology/ken082.
Article
CAS
PubMed
Google Scholar
Lories RJ, Derese I, de Bari C, Luyten FP: Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum. 2007, 56: 489-497. 10.1002/art.22372.
Article
PubMed
Google Scholar
van der Heijde D, Salonen D, Weissman BN, Landewé R, Maksymowych WP, Kupper H, Ballal S, Gibson E, Wong R: Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther. 2009, 11: R127-10.1186/ar2794.
Article
PubMed Central
PubMed
Google Scholar
van der Heijde D, Landewé R, Einstein S, Ory P, Vosse D, Ni L, Lin SL, Tsuji W, Davis JC: Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum. 2008, 58: 1324-1331. 10.1002/art.23471.
Article
CAS
PubMed
Google Scholar
van der Heijde D, Landewé R, Baraliakos X, Houben H, van Tubergen A, Williamson P, Xu W, Baker D, Goldstein N, Braun J: Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group. Arthritis Rheum. 2008, 58: 3063-3070. 10.1002/art.23901.
Article
PubMed
Google Scholar
Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme. J Immunol. 2011, 186: 1909-1913. 10.4049/jimmunol.1003337.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U: Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci USA. 2011, 108: 7745-7750. 10.1073/pnas.1101262108.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haroon N, Maksymowych W, Rahman P, Tsui F, O'Shea F, Inman R: Radiographic severity in ankylosing spondylitis is associated with polymorphism in large multifunctional peptidase 2 (LMP2) in the Spondyloarthritis Research Consortium of Canada cohort. Arthritis Rheum. 2012, 64: 1119-1126. 10.1002/art.33430.
Article
CAS
PubMed
Google Scholar
Haroon N, Tsui FW, Uchanska-Ziegler B, Ziegler A, Inman RD: Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis. Ann Rheum Dis. 2012, 71: 589-595. 10.1136/annrheumdis-2011-200347.
Article
CAS
PubMed
Google Scholar