Skip to main content
Figure 3 | Arthritis Research & Therapy

Figure 3

From: Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

Figure 3

Frequency of circulating pDCs, pDCs IFN-α+/TNF-α+ after TLR-9/7 stimulation and lupus disease activity. (A) Flow cytometric analysis of pDCs (HLA-DR+CD123+ cells) found in the PBMCs in one representative subject (left). Comparison of the frequency of circulating pDCs found in SLE subjects (white circles) and healthy controls (black circles) (right). (B) Absence of statistical correlation between the frequency of CD123+ pDCs IFN-α+ (white triangles) or TNF-α+ (black triangles) after TLR-9 (left) or TLR-7 (right) stimulation and disease activity assessed by using the Systemic Lupus Activity Questionnaire (SLAQ) in SLE patients (TLR-9 stimulation: IFN-α/SLAQ, r = -0.20, P = 0.23; TNF-α/SLAQ, r = -0.08, P = 0.62) (TLR-7 stimulation: IFN-α/SLAQ, r = -0.18, P = 0.28; TNF-α/SLAQ, r = -0.01, P = 0.96). In each case, the lines represent the mean value and the error bars show the standard deviation.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us