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Figure 1 | Arthritis Research & Therapy

Figure 1

From: B-cell targeted therapeutics in clinical development

Figure 1

Schematic representation of B-cell differentiation and maturation states. Schematic representation of B-cell differentiation and maturation states with respect to expression of CD19 and CD20, CD22, CD40 and B-cell activating factor receptor (BAFF-R) as well as their functions as discussed in the main text. There is of course a variety of additional surface markers characterizing various subpopulations of B cells (for reviews see [4, 12]).

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