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Arthritis Research & Therapy

Open Access

SLE risk alleles and cell development and activation

  • SJ Kim1,
  • N Manjarrez Orduno1,
  • PK Gregersen1 and
  • B Diamond1
Arthritis Research & Therapy201214(Suppl 3):A8

Published: 27 September 2012


Public HealthDendritic CellHealthy IndividualProinflammatory CytokineReceptor Signaling

Understanding the functionality of lupus susceptibility alleles may best be done using cells of healthy individuals harboring one or two copies of the susceptibility allele. With this approach, confounding variables introduced by disease and medication are avoided. We have studied the SLE susceptibility allele of Blimp-1 in dendritic cells and Csk in B cells. The Blimp-1 risk allele exhibits low expression and leads to an increased secretion of proinflammatory cytokines. The Csk risk allele leads to enhanced expression and an increased response to B-cell receptor signaling. These effects of the risk alleles on activated or resting cells, respectively, provide insight into disease pathogenesis.

Authors’ Affiliations

Feinstein Institute for Medical Research, Manhasset, USA


© Kim et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.