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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells

Figure 3

Electromobility shift assay (EMSA) of nuclear extracts from CD4+ T cells (preincubated with anti-CD4 mAbs or stimulated with PMA/ionomycin) for AP-1 (a) and NF-κB (b). One representative phosphoimage of three independent experiments is shown (upper panels). Quantification of the bands of all three experiments is shown below (means ± SEM). All three anti-CD4 mAbs slightly decreased the AP-1 activity, and RIB5/2 induced a profound, significant increase of NF-κB activity. *P ≤ 0.05 in comparison with the isotype control, #P ≤ 0.05 in comparison with W3/25, §P ≤ 0.05 in comparison with OX35, &P ≤ 0.05 in comparison with RIB5/2.

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Arthritis Research & Therapy

ISSN: 1478-6362

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