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Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply
Arthritis Research & Therapy volume 15, Article number: 406 (2013)
First, in our study , female Lewis rats have been used in order to induce arthritis. This experimental model of arthritis was well described in our previous study published in Molecular Therapy . Actually, a number of researchers use male or female animals to induce arthritis. For example, the use of female rats to induce arthritis has been reported in several recent articles [4–11]. In our unpublished data, we have shown that (a) adjuvant most likely induces arthritis equally in female and male Lewis rats and (b) female and male Lewis rats with arthritis have similar levels of lipid peroxidation products and cardiac fibrosis markers in heart tissues. These data were obtained by using a small cohort of male Lewis rats (n = 3), and we are keeping in mind that additional experiments will be performed in a future project of ours with a large cohort of male rats.
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The authors declare that they have no competing interests.
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Shi, Q., Abusarah, J., Baroudi, G. et al. Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply. Arthritis Res Ther 15, 406 (2013). https://doi.org/10.1186/ar4196
- Rheumatoid Arthritis
- Lipid Peroxidation
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