Noss EH, Brenner MB: The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev. 2008, 223: 252-270. 10.1111/j.1600-065X.2008.00648.x.
Article
CAS
PubMed
Google Scholar
Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T: Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology. 2006, 45: 669-675. 10.1093/rheumatology/kel065.
Article
CAS
PubMed
Google Scholar
Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol. 1996, 149: 1607-1615.
CAS
PubMed
PubMed Central
Google Scholar
Lefèvre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnäker EM, Tarner IH, Robbins PD, Evans CH, Stürz H, Steinmeyer J, Gay S, Schölmerich J, Pap T, Müller-Ladner U, Neumann E: Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med. 2009, 15: 1414-1420. 10.1038/nm.2050.
Article
PubMed
PubMed Central
Google Scholar
Fukudome K, Esmon CT: Identification, cloning, and regulation of a novel endothelial cell protein c activated protein c receptor. J Biol Chem. 1994, 269: 26486-26491.
CAS
PubMed
Google Scholar
Bouwens EA, Mosnier LO: EPCR encryption induces cellular APC resistance. Blood. 2012, 119: 2703-2705. 10.1182/blood-2012-01-400762.
Article
CAS
PubMed
Google Scholar
Xue M, March L, Sambrook PN, Fukudome F, Jackson CJ: Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann Rheum Dis. 2007, 66: 1574-1580. 10.1136/ard.2006.068239.
Article
CAS
PubMed
PubMed Central
Google Scholar
Esmon CT: Structure and functions of the endothelial cell protein C receptor. Crit Care Med. 2004, 32: S298-S301. 10.1097/01.CCM.0000126128.64614.81.
Article
CAS
PubMed
Google Scholar
Gramling MW, Beaulieu LM, Church FC: Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction. Exp Cell Res. 2010, 316: 314-328. 10.1016/j.yexcr.2009.10.024.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ducros E, Mirshahi S, Azzazene D, Camilleri-Broët S, Mery E, Al Farsi H, Althawadi H, Besbess S, Chidiac J, Pujade-Lauraine E, Therwath A, Soria J, Mirshahi M: Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset. Int J Oncol. 2012, 41: 433-440.
CAS
PubMed
PubMed Central
Google Scholar
Antón I, Molina E, Luis-Ravelo D, Zandueta C, Valencia K, Ormazabal C, Martínez-Canarias S, Perurena N, Pajares MJ, Agorreta J, Montuenga LM, Segura V, Wistuba II, De Las Rivas J, Hermida J, Lecanda F: Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med. 2012, 186: 96-105. 10.1164/rccm.201110-1826OC.
Article
PubMed
Google Scholar
Xu J, Qu D, Esmon NL, Esmon CT: Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem. 2000, 275: 6038-6044. 10.1074/jbc.275.8.6038.
Article
CAS
PubMed
Google Scholar
Qu D, Wang Y, Esmon NL, Esmon CT: Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. J Thromb Haemost. 2007, 5: 395-402. 10.1111/j.1538-7836.2007.02347.x.
Article
CAS
PubMed
Google Scholar
Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT: Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem. 2000, 275: 5447-5452. 10.1074/jbc.275.8.5447.
Article
CAS
PubMed
Google Scholar
Kurosawa S, Stearnskurosawa DJ, Carson CW, Dangelo A, Dellavalle P, Esmon CT: Plasma levels of endothelial cell protein c receptor are elevated in patients with sepsis and systemic lupus erythematosus - lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood. 1998, 91: 725-727.
CAS
PubMed
Google Scholar
Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT: Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood. 2000, 95: 1687-1693.
CAS
PubMed
Google Scholar
Bilgic A, Ozdemir FN, Bayraktar N, Karakus S, Sasak G, Arat Z, Sezer S, Haberal M: Soluble endothelial protein C receptor: influence on arteriovenous fistula thrombosis development in hemodialysis patients. Am J Nephrol. 2007, 27: 366-372.
CAS
PubMed
Google Scholar
Lopez-Sagaseta J, Puy C, Tamayo I, Allende M, Cervero J, Velasco SE, Esmon CT, Montes R, Hermida J: sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. Blood. 2012, 119: 2914-2921. 10.1182/blood-2011-05-353409.
Article
CAS
PubMed
Google Scholar
Pruzanski W, Vadas P: Phospholipase A2-a mediator between proximal and distal effectors of inflammation. Immunol Today. 1991, 12: 143-146.
CAS
PubMed
Google Scholar
Leistad L, Feuerherm AJ, Ostensen M, Faxvaag A, Johansen B: Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis. Clin Chem Lab Med. 2004, 42: 602-610.
Article
CAS
PubMed
Google Scholar
Masuda S, Murakami M, Komiyama K, Ishihara M, Ishikawa Y, Ishii T, Kudo I: Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells. FEBS J. 2005, 272: 655-672. 10.1111/j.1742-4658.2004.04489.x.
Article
CAS
PubMed
Google Scholar
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M: Development of criteria for the classification and reporting of osteoarthritis, Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986, 8: 49-
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002/art.1780310302.
Article
CAS
PubMed
Google Scholar
Herron GS, Banda MJ, Clark EJ, Gavrilovic J, Werb Z: Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem. 1986, 261: 2814-2818.
CAS
PubMed
Google Scholar
Korff T, Augustin HG: Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci. 1999, 112: 3249-3258.
CAS
PubMed
Google Scholar
Xue M, Chan YK, Shen K, Dervish S, March L, Sambrook PN, Jackson CJ: Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 2012, 64: 88-98. 10.1002/art.33323.
Article
CAS
PubMed
Google Scholar
Schmitz N, Laverty S, Kraus VB, Aigner T: Basic methods in histopathology of joint tissues. Osteoarthritis Cartilage. 2010, 18: S113-S116.
Article
PubMed
Google Scholar
Farndale RW, Buttle DJ, Barrett AJ: Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986, 883: 173-177. 10.1016/0304-4165(86)90306-5.
Article
CAS
PubMed
Google Scholar
Korb-Pap A, Stratis A, Mühlenberg K, Niederreiter B, Hayer S, Echtermeyer F, Stange R, Zwerina J, Pap T, Pavenstädt H, Schett G, Smolen JS, Redlich K: Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis. Ann Rheum Dis. 2012, 71: 1004-1011. 10.1136/annrheumdis-2011-200386.
Article
CAS
PubMed
Google Scholar
Nguyen M, Arkell J, Jackson CJ: Activated protein C directly activates human endothelial gelatinase A. J Biol Chem. 2000, 275: 9095-9098. 10.1074/jbc.275.13.9095.
Article
CAS
PubMed
Google Scholar
Goldring SR: Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford). 2003, 42: 11-16.
Article
Google Scholar
Pretzel D, Pohlers D, Weinert S, Kinne RW: In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage. Arthritis Res Ther. 2009, 11: R25-10.1186/ar2618.
Article
PubMed
PubMed Central
Google Scholar
Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB: Cadherin-11 in synovial lining formation and pathology in arthritis. Science. 2007, 315: 1006-1010. 10.1126/science.1137306.
Article
CAS
PubMed
Google Scholar
Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, Zenz P, Redlich K, Xu Q, Steiner G: Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum. 2000, 43: 2501-2512. 10.1002/1529-0131(200011)43:11<2501::AID-ANR18>3.0.CO;2-K.
Article
CAS
PubMed
Google Scholar
Zhang Y, Dong J, He P, Li W, Zhang Q, Li N, Sun T: Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. Inflammation. 2012, 35: 377-387. 10.1007/s10753-011-9365-x.
Article
CAS
PubMed
Google Scholar
Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS: c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001, 108: 73-81. 10.1172/JCI12466.
Article
CAS
PubMed
PubMed Central
Google Scholar
de Launay D, van de Sande MG, de Hair MJ, Grabiec AM, van de Sande GP, Lehmann KA, Wijbrandts CA, van Baarsen LG, Gerlag DM, Tak PP, Reedquist KA: Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Ann Rheum Dis. 1987, 2012: 415-423.
Google Scholar
Gortz B, Hayer S, Tuerck B, Zwerina J, Smolen JS, Schett G: Tumour necrosis factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivo. Arthritis Res Ther. 2005, 7: R1140-R1147. 10.1186/ar1797.
Article
PubMed
PubMed Central
Google Scholar
Gleeson EM, O'Donnell JS, Preston RJ: The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci. 2012, 69: 717-726. 10.1007/s00018-011-0825-0.
Article
CAS
PubMed
Google Scholar
Joosten LA, Helsen MM, Saxne T, van De Loo FA, Heinegard D, van Den Berg WB: IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol. 1999, 163: 5049-5055.
CAS
PubMed
Google Scholar
Trebec-Reynolds DP, Voronov I, Heersche JN, Manolson MF: IL-1alpha and IL-1beta have different effects on formation and activity of large osteoclasts. J Cell Biochem. 2010, 109: 975-982.
CAS
PubMed
Google Scholar
Criswell LA: Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis. Immunol Rev. 2010, 233: 55-61. 10.1111/j.0105-2896.2009.00862.x.
Article
CAS
PubMed
Google Scholar
Xue M, Minhas N, Chow SO, Dervish S, Sambrook PN, March L, Jackson CJ: Endogenous protein C is essential for the functional integrity of human endothelial cells. Cell Mol Life Sci. 2010, 67: 1537-1546. 10.1007/s00018-010-0269-y.
Article
CAS
PubMed
Google Scholar
Itoh T, Matsuda H, Tanioka M, Kuwabara K, Itohara S, Suzuki R: The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J Immunol. 2002, 169: 2643-2647.
Article
CAS
PubMed
Google Scholar
Bezuhly M, Cullen R, Esmon CT, Morris SF, West KA, Johnston B, Liwski RS: Role of activated protein C and its receptor in inhibition of tumor metastasis. Blood. 2009, 113: 3371-3374. 10.1182/blood-2008-05-159434.
Article
CAS
PubMed
Google Scholar
Menschikowski M, Hagelgans A, Eisenhofer G, Siegert G: Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways. Exp Cell Res. 2009, 315: 2673-2682. 10.1016/j.yexcr.2009.05.015.
Article
CAS
PubMed
Google Scholar
Wu J, Zhou Z, Ye S, Dai H, Ma L, Xu X, Li X: Detection of soluble endothelial protein C receptor (sEPCR) in patients with CHD, DM and SLE. Zhonghua XueYeXueZa Zhi. 2000, 21: 472-474.
CAS
Google Scholar
Ducros E, Mirshahi SS, Faussat AM, Mirshahi P, Dimicoli S, Tang R, Pardo J, Ibrahim J, Marie JP, Therwath A, Soria J, Mirshahi M: Soluble endothelial protein C receptor (sEPCR) is likely a biomarker of cancer-associated hypercoagulability in human hematologic malignancies. Cancer Med. 2012, 1: 261-267. 10.1002/cam4.11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Montes R, Puy C, Molina E, Hermida J: Is EPCR a multi-ligand receptor? Pros and cons. Thromb Haemost. 2012, 107: 815-826. 10.1160/TH11-11-0766.
Article
CAS
PubMed
Google Scholar