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  • Meeting abstract
  • Open Access

Blimp-1 and systemic lupus erythematosus

  • 1Email author,
  • 1,
  • 2 and
  • 2
Arthritis Research & Therapy201416 (Suppl 1) :A22

https://doi.org/10.1186/ar4638

  • Published:

Keywords

  • Estrogen
  • Systemic Lupus Erythematosus
  • Dendritic Cell
  • Healthy Individual
  • Risk Allele

Our laboratory has been studying the impact of low Blimp-1 expression on dendritic cell function in SLE, analyzing both a mouse model of SLE in which there is a deletion of Blimp-1 in CD11c dendritic cells (DC Blimp-1KO mice) and healthy individuals with the SLE risk allele of Blimp-1. This allele leads to reduced Blimp-1 expression in dendritic cells. Low expression of Blimp-1 alters cytokine expression following TLR activation and antigen-processing machinery. This leads to a highly distinct TCR repertoire in T-follicular helper cells in DC Blimp-1KO mice. Much of this phenotype is under estrogen regulation. These data therefore provide an integrated explanation for altered cytokines, autoantibodies and female predisposition in SLE.

Authors’ Affiliations

(1)
Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, USA
(2)
The University of Texas at Austin, TX, USA

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