Volume 16 Supplement 1

Lupus 2014: New Targets, New Approaches

Open Access

Blimp-1 and systemic lupus erythematosus

  • Betty Diamond1Email author,
  • Sun Jung Kim1,
  • Sebastian Schaetzle2 and
  • George Georgiou2
Arthritis Research & Therapy201416(Suppl 1):A22

https://doi.org/10.1186/ar4638

Published: 18 September 2014

Our laboratory has been studying the impact of low Blimp-1 expression on dendritic cell function in SLE, analyzing both a mouse model of SLE in which there is a deletion of Blimp-1 in CD11c dendritic cells (DC Blimp-1KO mice) and healthy individuals with the SLE risk allele of Blimp-1. This allele leads to reduced Blimp-1 expression in dendritic cells. Low expression of Blimp-1 alters cytokine expression following TLR activation and antigen-processing machinery. This leads to a highly distinct TCR repertoire in T-follicular helper cells in DC Blimp-1KO mice. Much of this phenotype is under estrogen regulation. These data therefore provide an integrated explanation for altered cytokines, autoantibodies and female predisposition in SLE.

Authors’ Affiliations

(1)
Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research
(2)
The University of Texas at Austin

Copyright

© Diamond et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement