- Meeting abstract
- Open Access
HLA DRB101 and macrophagic myofasciitis
© BioMed Central Ltd 2003
- Received: 14 January 2003
- Published: 24 February 2003
- Public Health
- Polymerase Chain Reaction
- Allele Frequency
- Genetic Susceptibility
- Inflammatory Infiltrate
Macrophagic myofasciitis (MMF) is characterised by specific myopathological alterations with inflammatory infiltrates of the monocyte/macrophage lineage containing aluminic inclusions.
The aim of this study was to analyse the HLA-DRB1 polymorphism in determining genetic susceptibility to MMF.
HLA-DRB1 alleles were defined by polymerase chain reaction SSOP/SSP genotyping in 10 European Mediterranean MMF patients and 230 unrelated healthy controls.
An increased frequency of HLA-DRB1*01 was observed in MMF patients (66%) in comparison with controls (17%) (OR 9.8, CI 2.0–62.2) (P < 0.002, Pc < 0.03). There was no significant difference in the distribution of the remaining HLA-DRB1 alleles frequencies between MMF and controls.
In Southern France, HLA-DRB1*01 is significantly associated with MMF.