Skip to main content
Download PDF

Volume 5 Supplement 1

23rd European Workshop for Rheumatology Research

  • Meeting abstract
  • Published:

HLA DRB101 and macrophagic myofasciitis

Arthritis Res Ther volume 5, Article number: 70 (2003) Cite this article

Background

Macrophagic myofasciitis (MMF) is characterised by specific myopathological alterations with inflammatory infiltrates of the monocyte/macrophage lineage containing aluminic inclusions.

Objective

The aim of this study was to analyse the HLA-DRB1 polymorphism in determining genetic susceptibility to MMF.

Methods

HLA-DRB1 alleles were defined by polymerase chain reaction SSOP/SSP genotyping in 10 European Mediterranean MMF patients and 230 unrelated healthy controls.

Results

An increased frequency of HLA-DRB1*01 was observed in MMF patients (66%) in comparison with controls (17%) (OR 9.8, CI 2.0–62.2) (P < 0.002, Pc < 0.03). There was no significant difference in the distribution of the remaining HLA-DRB1 alleles frequencies between MMF and controls.

Conclusion

In Southern France, HLA-DRB1*01 is significantly associated with MMF.

Author information

Authors and Affiliations

  1. Service de Rhumatologie, Hôpital de La Conception, Marseille, France

    S Guis, JP Mattei, G Kaplanski & J Roudier

  2. Service d'Anatomie-Pathologie et de Neuropathologie, Hôpital de la Timone, Marseille, France

    JF Pellissier, J Pelletier & D Figarella-Branger

  3. Service de Neurologie, Hôpital Sainte Marguerite, Marseille, France

    F Nicoli

  4. Laboratoire d'Immunogénétique, Etablissement Français du Sang 'Alpes-Méditerranée', Marseille, France

    D Reviron

  5. Service de Médecine Interne, Hôpital Henri Mondor, Créteil, France

    RK Gherardi

Authors
  1. S Guis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JF Pellissier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F Nicoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D Reviron
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. JP Mattei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. RK Gherardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J Pelletier
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Kaplanski
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. D Figarella-Branger
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. J Roudier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guis, S., Pellissier, J., Nicoli, F. et al. HLA DRB101 and macrophagic myofasciitis. Arthritis Res Ther 5 (Suppl 1), 70 (2003). https://doi.org/10.1186/ar700

Download citation

  • Received:

  • Published:

  • DOI: https://doi.org/10.1186/ar700

Keywords

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us