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HLA DRB101 and macrophagic myofasciitis


Macrophagic myofasciitis (MMF) is characterised by specific myopathological alterations with inflammatory infiltrates of the monocyte/macrophage lineage containing aluminic inclusions.


The aim of this study was to analyse the HLA-DRB1 polymorphism in determining genetic susceptibility to MMF.


HLA-DRB1 alleles were defined by polymerase chain reaction SSOP/SSP genotyping in 10 European Mediterranean MMF patients and 230 unrelated healthy controls.


An increased frequency of HLA-DRB1*01 was observed in MMF patients (66%) in comparison with controls (17%) (OR 9.8, CI 2.0–62.2) (P < 0.002, Pc < 0.03). There was no significant difference in the distribution of the remaining HLA-DRB1 alleles frequencies between MMF and controls.


In Southern France, HLA-DRB1*01 is significantly associated with MMF.

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Guis, S., Pellissier, J., Nicoli, F. et al. HLA DRB101 and macrophagic myofasciitis. Arthritis Res Ther 5 (Suppl 1), 70 (2003).

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