Skip to main content

Advertisement

HLA DRB101 and macrophagic myofasciitis

  • 949 Accesses

Background

Macrophagic myofasciitis (MMF) is characterised by specific myopathological alterations with inflammatory infiltrates of the monocyte/macrophage lineage containing aluminic inclusions.

Objective

The aim of this study was to analyse the HLA-DRB1 polymorphism in determining genetic susceptibility to MMF.

Methods

HLA-DRB1 alleles were defined by polymerase chain reaction SSOP/SSP genotyping in 10 European Mediterranean MMF patients and 230 unrelated healthy controls.

Results

An increased frequency of HLA-DRB1*01 was observed in MMF patients (66%) in comparison with controls (17%) (OR 9.8, CI 2.0–62.2) (P < 0.002, Pc < 0.03). There was no significant difference in the distribution of the remaining HLA-DRB1 alleles frequencies between MMF and controls.

Conclusion

In Southern France, HLA-DRB1*01 is significantly associated with MMF.

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Guis, S., Pellissier, J., Nicoli, F. et al. HLA DRB101 and macrophagic myofasciitis. Arthritis Res Ther 5, 70 (2003) doi:10.1186/ar700

Download citation

Keywords

  • Public Health
  • Polymerase Chain Reaction
  • Allele Frequency
  • Genetic Susceptibility
  • Inflammatory Infiltrate