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  • Meeting abstract
  • Open Access

HLA DRB101 and macrophagic myofasciitis

  • 1,
  • 2,
  • 3,
  • 4,
  • 1,
  • 5,
  • 2,
  • 1,
  • 2 and
  • 1
Arthritis Res Ther20035 (Suppl 1) :70

https://doi.org/10.1186/ar700

  • Received: 14 January 2003
  • Published:

Keywords

  • Public Health
  • Polymerase Chain Reaction
  • Allele Frequency
  • Genetic Susceptibility
  • Inflammatory Infiltrate

Background

Macrophagic myofasciitis (MMF) is characterised by specific myopathological alterations with inflammatory infiltrates of the monocyte/macrophage lineage containing aluminic inclusions.

Objective

The aim of this study was to analyse the HLA-DRB1 polymorphism in determining genetic susceptibility to MMF.

Methods

HLA-DRB1 alleles were defined by polymerase chain reaction SSOP/SSP genotyping in 10 European Mediterranean MMF patients and 230 unrelated healthy controls.

Results

An increased frequency of HLA-DRB1*01 was observed in MMF patients (66%) in comparison with controls (17%) (OR 9.8, CI 2.0–62.2) (P < 0.002, Pc < 0.03). There was no significant difference in the distribution of the remaining HLA-DRB1 alleles frequencies between MMF and controls.

Conclusion

In Southern France, HLA-DRB1*01 is significantly associated with MMF.

Authors’ Affiliations

(1)
Service de Rhumatologie, Hôpital de La Conception, Marseille, France
(2)
Service d'Anatomie-Pathologie et de Neuropathologie, Hôpital de la Timone, Marseille, France
(3)
Service de Neurologie, Hôpital Sainte Marguerite, Marseille, France
(4)
Laboratoire d'Immunogénétique, Etablissement Français du Sang 'Alpes-Méditerranée', Marseille, France
(5)
Service de Médecine Interne, Hôpital Henri Mondor, Créteil, France

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