Volume 5 Supplement 1

23rd European Workshop for Rheumatology Research

Meeting abstracts

The organizer would like to thank the following companies who have generously supported the 23rd European Workshop for Rheumatology Research: Abbott, Amgen, Aventis, Merck Sharp and Dohme, Novartis, Pharmacia, Schering-Plough, Wyeth

23rd European Workshop for Rheumatology Research.

Marseille, France27 February - 2 March 2003

Page 1 of 3

Rheumatoid arthritis – class prediction by autoreactivity profiles

Authors: R Bergholz, F Schumann, S Behrens, U Ungethüm, G Valet, WA Schmidt, GR Burmester, JM Engel, WJ van Venrooij, G Steiner and S Bläβ

Citation: Arthritis Res Ther 2003 5(Suppl 1):1

Content type: Meeting abstract Published on: 24 February 2003
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Investigation of the reactivity patterns of antifilaggrin antibodies in sera and synovial fluids from patients with rheumatoid arthritis using citrullinated synthetic peptides

Authors: M Brózik, J Szakonyi, A Magyar, B Rojkovich, R Tobi, F Hudecz, P Gergely and K Merétey

Citation: Arthritis Res Ther 2003 5(Suppl 1):2

Content type: Meeting abstract Published on: 24 February 2003
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Analysis of the peptidylarginine deiminase V gene in rheumatoid arthritis

Authors: L Caponi, E Petit-Teixeira, M Sebbag, F Bongiorni, S Moscato, F Pratesi, J Osorio, M Guerrin-Weber, F Cornelis, G Serre and P Migliorini

Citation: Arthritis Res Ther 2003 5(Suppl 1):3

Content type: Meeting abstract Published on: 24 February 2003
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Subclass distribution of IgG autoantibodies to deiminated fibrinogen in rheumatoid arthritis

Authors: S Chapuy-Regaud, L Nogueira, C Clavel, M Sebbag, C Vincent and G Serre

Citation: Arthritis Res Ther 2003 5(Suppl 1):4

Content type: Meeting abstract Published on: 24 February 2003
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Peptidylarginine deiminase isoforms expressed in the synovial membrane of rheumatoid arthritis patients

Authors: S Chapuy-Regaud, M Sebbag, R Nachat, D Baeten, V Foulquier, M Simon, T Senshu, M Yamada, H Takahara, F De Keyser and G Serre

Citation: Arthritis Res Ther 2003 5(Suppl 1):5

Content type: Meeting abstract Published on: 24 February 2003
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Paratope diversity of anti-prothrombin antibodies

Authors: S Cucnik, T Kveder and B Bozic

Citation: Arthritis Res Ther 2003 5(Suppl 1):6

Content type: Meeting abstract Published on: 24 February 2003
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High-affinity antibodies against β₂-glycoprotein I

Authors: S Cucnik, T Kveder, A Ambrozic and B Borut

Citation: Arthritis Res Ther 2003 5(Suppl 1):7

Content type: Meeting abstract Published on: 24 February 2003
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Anti-Ro/SSA antibodies in rheumatoid arthritis (RA)

Authors: F Franceschini, I Cavazzana, F Malacarne, P Airò, R Cattaneo, N Del Papa, A Radice and RA Sinico

Citation: Arthritis Res Ther 2003 5(Suppl 1):8

Content type: Meeting abstract Published on: 24 February 2003
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Presence of anti-RNP-A and anti-RNP-C antibodies is inversely associated with renal symptoms of systemic lupus erythematosus

Authors: I Hoffman, I Peene, L Meheus, K De Bosschere, F Hulstaert, TWJ Huizinga, L Cebecauer, D Isenberg, EM Veys and F De Keyser

Citation: Arthritis Res Ther 2003 5(Suppl 1):9

Content type: Meeting abstract Published on: 24 February 2003
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Cultured salivary gland epithelial cells release exosomes that contain the Sjögren's-syndrome-associated autoantigenic ribonucleoproteins Ro/SSA and La/SSB

Authors: EK Kapsogeorgou, ID Dimitriou, RF Abu-Helu, HM Moutsopoulos and MN Manoussakis

Citation: Arthritis Res Ther 2003 5(Suppl 1):10

Content type: Meeting abstract Published on: 24 February 2003
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Low frequency of phosphatidylserine/prothrombin complex antibodies in a cohort of patients with anticardiolipin antibodies and recent thrombosis

Authors: H Locht

Citation: Arthritis Res Ther 2003 5(Suppl 1):11

Content type: Meeting abstract Published on: 24 February 2003
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Anticardiolipin antibodies of IgG and IgM isotypes reflect different forms of recent thromboembolic events

Authors: H Locht and A Wiik

Citation: Arthritis Res Ther 2003 5(Suppl 1):12

Content type: Meeting abstract Published on: 24 February 2003
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Autoantibodies in osteoarthritis

Authors: J Menard, J Neidel, C Perka, M Sparmann and B Mueller

Citation: Arthritis Res Ther 2003 5(Suppl 1):13

Content type: Meeting abstract Published on: 24 February 2003
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The infectious origin of the antiphospholipid syndrome: induction by passive transfer of anti-β2GPI antibodies induced by common bacteria

Authors: M Blank, I Krause, M Fridkin, N Keller, J Kopolovic, I Goldberg, A Tobar and Y Shoenfeld

Citation: Arthritis Res Ther 2003 5(Suppl 1):14

Content type: Meeting abstract Published on: 24 February 2003
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FcγRI up-regulation induced by local adenoviral-mediated IFN-γ production aggravates chondrocyte death during immune-complex-mediated arthritis

Authors: K Nabbe, PL van Lent, AE Holthuysen, AW Sloetjes, J Kolls, JS Verbeek and WB van den Berg

Citation: Arthritis Res Ther 2003 5(Suppl 1):15

Content type: Meeting abstract Published on: 24 February 2003
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The diagnostic significance of autoantibodies in patients with very early rheumatoid arthritis

Authors: V Nell, K Machold, W Hueber, G Eberl, H Hiesberger, E Hoefler, J Smolen and G Steiner

Citation: Arthritis Res Ther 2003 5(Suppl 1):16

Content type: Meeting abstract Published on: 24 February 2003
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A rapid ELISA based method to determine peptidyl-arginine deiminase activity in biological samples

Authors: S Nijenhuis, AJW Zendman, JMH Raats, GJM Pruijn and WJ van Venrooij

Citation: Arthritis Res Ther 2003 5(Suppl 1):17

Content type: Meeting abstract Published on: 24 February 2003
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Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for early rheumatoid arthritis diagnosis

Authors: L Nogueira, S Chapuy-Regaud, A Constantin, C Clavel, M Sebbag, A Cantagrel, C Vincent and G Serre

Citation: Arthritis Res Ther 2003 5(Suppl 1):18

Content type: Meeting abstract Published on: 24 February 2003
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Anti-BIP antibodies in rheumatoid arthritis

Authors: GS Panayi, M Bodman-Smith and V Corrigall

Citation: Arthritis Res Ther 2003 5(Suppl 1):19

Content type: Meeting abstract Published on: 24 February 2003
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Antineutrophil cytoplasmic antibodies in synovial fluid from patients with early rheumatoid arthritis

Authors: M Puszczewicz, I Zimmermann-Górska, G Bialkowska-Puszczewicz and E Tatarkiewicz

Citation: Arthritis Res Ther 2003 5(Suppl 1):20

Content type: Meeting abstract Published on: 24 February 2003
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Biphasic decline/increase for anticitrulline and monophasic decline in anti-type II collagen antibody levels in recently diagnosed RA patients

Authors: J Rönnelid, S Rogberg, B Nordmark, J Lampa, I Dahlbom, T Hansson and L Klareskog

Citation: Arthritis Res Ther 2003 5(Suppl 1):21

Content type: Meeting abstract Published on: 24 February 2003
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Zinc finger domain of Ro60kD autoantigen is essential for binding of Ro52kD and autoantibodies

Authors: JG Routsias, A Makri, C Sakarellos, M Sakarellos-Daitsiotis, A Kosmopoulou, HM Moutsopoulos and AG Tzioufas

Citation: Arthritis Res Ther 2003 5(Suppl 1):22

Content type: Meeting abstract Published on: 24 February 2003
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Differential expression of IgVH mRNAs in human RA synovium detected by single-cell RT-PCR

Authors: S Ruzickova, Z Cimburek, J Niederlova, O Horvath, O Krystufkova, T Dörner and J Vencovsky

Citation: Arthritis Res Ther 2003 5(Suppl 1):23

Content type: Meeting abstract Published on: 24 February 2003
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Ability of second-generation anti-cyclic citrullinated peptide (CCP) to predict rheumatoid arthritis in patients with early arthritis

Authors: A Saraux, JM Berthelot, P Le Goff and P Youinou

Citation: Arthritis Res Ther 2003 5(Suppl 1):24

Content type: Meeting abstract Published on: 24 February 2003
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Autoantibodies to hnRNP-A2 in SLE: identification of disease-specific linear epitopes and correlation with disease activity and clinical features

Authors: G Schett, F Monneaux, E Hoefler, R Fritsch, M Tohidast-Akrad, J Smolen, S Muller and G Steiner

Citation: Arthritis Res Ther 2003 5(Suppl 1):25

Content type: Meeting abstract Published on: 24 February 2003
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Fcγ receptors complement interaction: new aspects in pathogenesis and treatment of vasculititis

Authors: RE Schmidt

Citation: Arthritis Res Ther 2003 5(Suppl 1):26

Content type: Meeting abstract Published on: 24 February 2003
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Linear epitopes of two different autoantigens (La/SSB and myelin basic protein) with a high degree of molecular similarity cause different humoral responses

Authors: A Terzoglou, JG Routsias, C Sakarellos, M Sakarellos-Daitsiotis, HM Moutsopoulos and AG Tzioufas

Citation: Arthritis Res Ther 2003 5(Suppl 1):27

Content type: Meeting abstract Published on: 24 February 2003
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Autoantibodies predict progression to rheumatoid arthritis in undifferentiated arthritis: a prospective cohort study

Authors: FA van Gaalen, SP Linn-Rasker, WJ van Venrooij, BA de Jong, FC Breedveld, CL Verweij, REM Toes and TWJ Huizinga

Citation: Arthritis Res Ther 2003 5(Suppl 1):28

Content type: Meeting abstract Published on: 24 February 2003
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Autoantibodies to GPI are predominantly present in extra-articular complications of human rheumatoid arthritis

Authors: FA van Gaalen, REM Toes, HJ Ditzel, M Schaller, CL Verweij and TWJ Huizinga

Citation: Arthritis Res Ther 2003 5(Suppl 1):29

Content type: Meeting abstract Published on: 24 February 2003
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Citrullination of synovial proteins in murine models of rheumatoid arthritis

Authors: E Vossenaar, S Nijenhuis, MM van Helsen, A van der Heijden, WB van den Berg, WJ van Venrooij and L Joosten

Citation: Arthritis Res Ther 2003 5(Suppl 1):30

Content type: Meeting abstract Published on: 24 February 2003
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Fibrinogen-specific T cells in rheumatoid arthritis

Authors: E Vossenaar, R Bergholz, F Schumann, GR Burmester, JM Engel, WJ van Venrooij and S Bläβ

Citation: Arthritis Res Ther 2003 5(Suppl 1):31

Content type: Meeting abstract Published on: 24 February 2003
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Elevated anti-serum amyloid P component (SAP) antibodies in SLE patients

Authors: G Zandman-Goddard, M Blank, P Langevitz, M Pras, Y Levy, T Witte, A Doria, J Rovensky and Y Shoenfeld

Citation: Arthritis Res Ther 2003 5(Suppl 1):32

Content type: Meeting abstract Published on: 24 February 2003
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Clinical and immunological effects of anti-TNF therapy in systemic lupus erythematosus (SLE)

Authors: M Aringer, G Steiner, WB Graninger, E Höfler, H Hiesberger, C-W Steiner and J Smolen

Citation: Arthritis Res Ther 2003 5(Suppl 1):33

Content type: Meeting abstract Published on: 24 February 2003
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Therapy with soluble TNF receptor (etanercept) induces apoptosis in rheumatoid arthritis (RA) synovium

Authors: AI Catrina, C Trollmo, J Lampa, E af Klint, Y Hermansson, L Klareskog and A-K Ulfgren

Citation: Arthritis Res Ther 2003 5(Suppl 1):34

Content type: Meeting abstract Published on: 24 February 2003
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The effect of methotrexate and mycophenolic acid on monokine production in vitro

Authors: S de Lathouder, AH Gerards, ER de Groot and LA Aarden

Citation: Arthritis Res Ther 2003 5(Suppl 1):35

Content type: Meeting abstract Published on: 24 February 2003
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Changes in rheumatoid factor reflect the inflammatory response (CRP and ESR) to infliximab treatment

Authors: L De Rycke, E Kruithof, N Van Damme, IEA Hoffman, F Van den Bosch, EM Veys and F De Keyser

Citation: Arthritis Res Ther 2003 5(Suppl 1):36

Content type: Meeting abstract Published on: 24 February 2003
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Promoter polymorphisms in the IL-18 gene are associated with rheumatoid arthritis in two independent clinical cohorts

Authors: JA Gracie, N Koyama, M Field, F McGarry, A Schobel, IB McInnes and B Moller

Citation: Arthritis Res Ther 2003 5(Suppl 1):37

Content type: Meeting abstract Published on: 24 February 2003
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Combination of the proinflammatory cytokines IL-1, TNF-α and IL-17 leads to enhanced expression and additional recruitment of AP-1 family members, Egr-1 and NF-κB in osteoblast-like cells

Authors: C Granet and P Miossec

Citation: Arthritis Res Ther 2003 5(Suppl 1):38

Content type: Meeting abstract Published on: 24 February 2003
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Expression of chemokines and their receptors in synovial tissue of patients with rheumatoid arthritis, osteoarthritis and reactive arthritis

Authors: JJ Haringman, TJM Smeets, MC Kraan and PP Tak

Citation: Arthritis Res Ther 2003 5(Suppl 1):39

Content type: Meeting abstract Published on: 24 February 2003
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Osteoprotegerin protects from generalized bone loss in TNF-transgenic mice

Authors: S Hayer, K Redlich, J Zwerina, B Bolon, C Dunstan, B Görtz, H Bergmeister, G Kollias, G Steiner, J Smolen and G Schett

Citation: Arthritis Res Ther 2003 5(Suppl 1):40

Content type: Meeting abstract Published on: 24 February 2003
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Influence of anti-TNF therapy on monocyte gene expression in rheumatoid arthritis

Authors: M Hernandez, L Martinez, O Kiesslich, N Tandon, M Janitz, H Lehrach, F Wagner, T Häupl, GR Burmester and B Stuhlmüller

Citation: Arthritis Res Ther 2003 5(Suppl 1):41

Content type: Meeting abstract Published on: 24 February 2003
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Endogenous IL-12p40 is crucial for antigen-induced arthritis and is partly involved in chronic relapsing streptococcal-cell-wall arthritis

Authors: M Jacobs, L Joosten, MMA Helsen, E Lubberts and WB van den Berg

Citation: Arthritis Res Ther 2003 5(Suppl 1):42

Content type: Meeting abstract Published on: 24 February 2003
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IL-18 directly promotes joint inflammation and induces cartilage destruction through IL-1

Authors: L Joosten, E Lubberts, MJM Wagenmans, MMA Helsen, FAJ van de Loo and WB van den Berg

Citation: Arthritis Res Ther 2003 5(Suppl 1):43

Content type: Meeting abstract Published on: 24 February 2003
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TNF polymorphisms are associated with the development of joint erosions in psoriatic arthritis

Authors: D Kane, J Balding, W Livingstone, L Mynett-Johnson, B Bresnihan, O Smith and O Fitzgerald

Citation: Arthritis Res Ther 2003 5(Suppl 1):44

Content type: Meeting abstract Published on: 24 February 2003
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Defect of Th1 immune response of whole blood cells from active patients with rheumatoid arthritis (RA)

Authors: M Kawashima and P Miossec

Citation: Arthritis Res Ther 2003 5(Suppl 1):45

Content type: Meeting abstract Published on: 24 February 2003
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TNF-α dependency of IL-17-induced joint pathology differs under naive and arthritis conditions in vivo

Authors: M Koenders, E Lubberts, L Joosten, B Oppers, L van den Bersselaar, J Kolls and WB van den Berg

Citation: Arthritis Res Ther 2003 5(Suppl 1):46

Content type: Meeting abstract Published on: 24 February 2003
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Differential effects of leflunomide and methotrexate on cytokine production in RA

Authors: MC Kraan, TJM Smeets, MJ van Loon, FC Breedveld, BAC Dijkmans and PP Tak

Citation: Arthritis Res Ther 2003 5(Suppl 1):47

Content type: Meeting abstract Published on: 24 February 2003
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Alveolar macrophages in scleroderma lung disease are activated by TGF-β and IL-4 but not TNF-α

Authors: I Luzina, S Atamas and B White

Citation: Arthritis Res Ther 2003 5(Suppl 1):48

Content type: Meeting abstract Published on: 24 February 2003
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Circulating bioactive TNF in rheumatoid arthritis patients treated with infliximab: link to clinical response

Authors: H Marotte and P Miossec

Citation: Arthritis Res Ther 2003 5(Suppl 1):49

Content type: Meeting abstract Published on: 24 February 2003
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Shared epitope and rheumatoid arthritis severity: association with infliximab treatment in a postmarketing study

Authors: H Marotte, P Gaudin, C Alexandre and P Miossec

Citation: Arthritis Res Ther 2003 5(Suppl 1):50

Content type: Meeting abstract Published on: 24 February 2003
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23rd European Workshop for Rheumatology Research

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