Volume 5 Supplement 3

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

Open Access

Implication of Synoviolin in pathogenesis of arthropathy

  • T Nakajima1
Arthritis Res Ther20035(Suppl 3):24

https://doi.org/10.1186/ar825

Published: 12 September 2003

Rheumatoid arthritis (RA) is one of the common disorders characterized with overgrowth of articular synovial cells, so-called 'pannus', and autoimmune reaction. To understand the pathomechanism of RA, we attempted to characterize the rheumatoid synovial cell and found a novel membranous protein, Synoviolin (synovial cell+ protein). Its overexpression causes arthropathy, resembling RA in mice. Moreover, the heterozygote of synoviolin (+/-) is resistant to anticollagen antibody-induced arthritis. These 'gain of function' and 'loss of function' analyses clearly indicate the pathogenetic role of synoviolin in arthropathy.

Authors’ Affiliations

(1)
Department of Genome Science, Institute of Medical Science, St Marianna University School of Medicine

Copyright

© The Author(s) 2003

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