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Implication of Synoviolin in pathogenesis of arthropathy

Rheumatoid arthritis (RA) is one of the common disorders characterized with overgrowth of articular synovial cells, so-called 'pannus', and autoimmune reaction. To understand the pathomechanism of RA, we attempted to characterize the rheumatoid synovial cell and found a novel membranous protein, Synoviolin (synovial cell+ protein). Its overexpression causes arthropathy, resembling RA in mice. Moreover, the heterozygote of synoviolin (+/-) is resistant to anticollagen antibody-induced arthritis. These 'gain of function' and 'loss of function' analyses clearly indicate the pathogenetic role of synoviolin in arthropathy.

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Nakajima, T. Implication of Synoviolin in pathogenesis of arthropathy. Arthritis Res Ther 5 (Suppl 3), 24 (2003).

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