Bresnihan B: Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol. 1999, 26: 717-719.
PubMed
Google Scholar
Burmester GR, Stuhlmüller B, Keyszer G, Kinne RW: Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?. Arthritis Rheum. 1997, 40: 5-18.
PubMed
Google Scholar
Kinne RW, Stuhlmüller B, Palombo-Kinne E, Burmester GR: The role of macrophages in the pathogenesis of rheumatoid arthritis. In: Rheumatoid Arthritis: The New frontiers in Pathogenesis and Treatment. Edited by Wollheim F, Firestein GS, Panayi GS. Oxford: Oxford University Press. 2000, : 69-87.
Google Scholar
Gracie JA, Forsey RJ, Chan WL: A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 1999, 104: 1393-1401.
PubMed
PubMed Central
Google Scholar
Michaelsson E, Holmdahl M, Engstrom A: Macrophages, but not dendritic cells, present collagen to T cells. Eur J Immunol. 1995, 25: 2234-2241.
PubMed
Google Scholar
Stuhlmüller B, Ungethüm U, Scholze S: Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2000, 43: 775-790.
PubMed
Google Scholar
Mulherin D, Fitzgerald O, Bresnihan B: Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 1996, 39: 115-124.
PubMed
Google Scholar
Hahn G, Stuhlmüller B, Hain N: Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy. J Clin Invest. 1993, 91: 862-870.
PubMed
PubMed Central
Google Scholar
Yanni G, Nabil M, Farahat MR, Poston RN, Panayi GS: Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann Rheum Dis. 1994, 53: 315-322.
PubMed
PubMed Central
Google Scholar
Bondeson J: The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen Pharmacol. 1997, 29: 127-150.
PubMed
Google Scholar
Feldmann M, Bondeson J, Brennan FM, Foxwell BM, Maini RN: The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?. Ann Rheum Dis. 1999, 58(suppl 1): 127-131.
Google Scholar
Bresnihan B, Alvaro-Gracia JM, Cobby M: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. 1998, 41: 2196-2204.
PubMed
Google Scholar
Bondeson J, Browne KA, Brennan FM, Foxwell BM, Feldmann M: Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysac-charide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent. J Immunol. 1999, 162: 2939-2945.
PubMed
Google Scholar
Wadsworth SA, Cavender DE, Beers SA: RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J Pharmacol Exp Ther. 1999, 291: 680-687.
PubMed
Google Scholar
Crofford LJ, Lipsky PE, Brooks P: Current comment: basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthritis Rheum. 2000, 43: 4-13.
PubMed
Google Scholar
Hogg N, Palmer DG, Revell PA: Mononuclear phagocytes of normal and rheumatoid synovial membrane identified by monoclonal antibodies. Immunology. 1985, 56: 673-681.
PubMed
PubMed Central
Google Scholar
Pirila L, Heino J: Altered integrin expression in rheumatoid synovial lining type B cells: in vitro cytokine regulation of alpha 1 beta 1, alpha 6 beta 1, and alpha v beta 5 integrins. J Rheumatol. 1996, 23: 1691-1698.
PubMed
Google Scholar
Klareskog L, Forsum U, Kabelitz D: Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of macrophage-like cells that express HLA-DR. Arthritis Rheum. 1982, 25: 488-501.
PubMed
Google Scholar
van den Berg TK, van Die I, de Lavalette CR: Regulation of sialoadhesin expression on rat macrophages. Induction by gluco-corticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide. J Immunol. 1996, 157: 3130-3138.
PubMed
Google Scholar
Kinne RW, Schmidt-Weber CB, Hoppe R: Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes. Arthritis Rheum. 1995, 38: 1777-1790.
PubMed
Google Scholar
Arend WP, Malyak M, Guthridge CJ, Gabay C: Interleukin-1 receptor antagonist: Role in biology. Annu Rev Immunol. 1998, 16: 27-55.
PubMed
Google Scholar
Miossec P, van den Berg W: Th1/Th2 cytokine balance in arthritis. Arthritis Rheum. 1997, 40: 2105-2115.
PubMed
Google Scholar
Koch AE: Review: angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. 1998, 41: 951-962.
PubMed
Google Scholar
Khalkhali-Ellis Z, Roodman ST, Knutsen AP: Expression of macrophage markers by a population of T cells obtained from synovial fluid of a subgroup of patients with juvenile rheumatoid arthritis. J Rheumatol. 1998, 25: 352-360.
PubMed
Google Scholar
Hirohata S, Yanagida T, Itoh K: Accelerated generation of CD14+ monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients. Arthritis Rheum. 1996, 39: 836-843.
PubMed
Google Scholar
Kotake S, Higaki M, Sato K: Detection of myeloid precursors (granulocyte/macrophage colony forming units) in the bone marrow adjacent to rheumatoid arthritis joints. J Rheumatol. 1992, 19: 1511-1516.
PubMed
Google Scholar
Jongen-Lavrencic M, Peeters HR, Wognum A: Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease. J Rheumatol. 1997, 24: 1504-1509.
PubMed
Google Scholar
Santiago-Schwarz F, Sullivan C, Rappa D, Carsons SE: Distinct alterations in lineage committed progenitor cells exist in the peripheral blood of patients with rheumatoid arthritis and primary Sjogren's syndrome. J Rheumatol. 1996, 23: 439-446.
PubMed
Google Scholar
Horie S, Nakada K, Masuyama J: Detection of large macrophage colony forming cells in the peripheral blood of patients with rheumatoid arthritis. J Rheumatol. 1997, 24: 1517-1521.
PubMed
Google Scholar
Lee BO, Ishihara K, Denno K: Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 1996, 39: 629-637.
PubMed
Google Scholar
De Benedetti F, Pignatti P, Massa M: Soluble tumour necrosis factor receptor levels reflect coagulation abnormalities in systemic juvenile chronic arthritis. Br J Rheumatol. 1997, 36: 581-588.
PubMed
Google Scholar
Klimiuk PA, Goronzy JJ, Bjor NJ, Beckenbaugh RD, Weyand CM: Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Am J Pathol. 1997, 151: 1311-1319.
PubMed
PubMed Central
Google Scholar
Palmer DG, Hogg N, Highton J, Hessian PA, Denholm I: Macrophage migration and maturation within rheumatoid nodules. Arthritis Rheum. 1987, 30: 728-736.
PubMed
Google Scholar
Hamilton JA: Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs. Lancet. 1993, 342: 536-539.
PubMed
Google Scholar
Wicks I, Cooley H, Szer J: Autologous hemopoietic stem cell transplantation: a possible cure for rheumatoid arthritis?. Arthritis Rheum. 1997, 40: 1005-1011.
PubMed
Google Scholar
Iguchi T, Kurosaka M, Ziff M: Electron microscopic study of HLA-DR and monocyte/macrophage staining cells in the rheumatoid synovial membrane. Arthritis Rheum. 1986, 29: 600-613.
PubMed
Google Scholar
Tak PP, Smeets TJ, Daha MR: Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum. 1997, 40: 217-225.
PubMed
Google Scholar
Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440.
PubMed
Google Scholar
Alsalameh S, Winter K, Al-Ward R: Distribution of TNF-alpha, TNF-R55 and TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-alpha is distributed mainly in the vicinity of TNF receptors in the deeper layers. Scand J Immunol. 1999, 49: 278-285. 10.1046/j.1365-3083.1999.00458.x.
PubMed
Google Scholar
Pettit AR, Thomas R: Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?. Immunol Cell Biol. 1999, 77: 420-427. 10.1046/j.1440-1711.1999.00855.x.
PubMed
Google Scholar
Tetlow LC, Lees M, Ogata Y, Nagase H, Woolley DE: Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP- 3) by rheumatoid synovial cells in vitro and in vivo. Rheumatol Int. 1993, 13: 53-59.
PubMed
Google Scholar
Ahrens D, Koch AE, Pope RM, Stein-Picarella M, Niedbala MJ: Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum. 1996, 39: 1576-1587.
PubMed
Google Scholar
Gravallese EM, Harada Y, Wang JT: Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998, 152: 943-951.
PubMed
PubMed Central
Google Scholar
Highton J, Carlisle B, Palmer DG: Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. 1995, 102: 541-546.
PubMed
PubMed Central
Google Scholar
Bomalaski JS, Clark MA, Zurier RB: Enhanced phospholipase activity in peripheral blood monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1986, 29: 312-318.
PubMed
Google Scholar
Schulze-Koops H, Davis LS, Kavanaugh AF, Lipsky PE: Elevated cytokine messenger RNA levels in the peripheral blood of patients with rheumatoid arthritis suggest different degrees of myeloid cell activation. Arthritis Rheum. 1997, 40: 639-647.
PubMed
Google Scholar
Liote F, Boval-Boizard B, Weill D, Kuntz D, Wautier JL: Blood monocyte activation in rheumatoid arthritis: Increased monocyte adhesiveness, integrin expression, and cytokine release. Clin Exp Immunol. 1996, 106: 13-19.
PubMed
PubMed Central
Google Scholar
Reibnegger G, Egg D, Fuchs D: Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis. Arthritis Rheum. 1986, 29: 1063-1070.
PubMed
Google Scholar
Gruber BL, Sorbi D, French DL: Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker. Clin Immunol Immunopathol. 1996, 78: 161-171. 10.1006/clin.1996.0025.
PubMed
Google Scholar
Heller RA, Schena M, Chai A: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 1997, 94: 2150-2155.
PubMed
PubMed Central
Google Scholar
Steven MM, Lennie SE, Sturrock RD, Gemmell CG: Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis. Ann Rheum Dis. 1984, 43: 435-439.
PubMed
PubMed Central
Google Scholar
Mazure G, Fernandes T, McCarthy DA: Blood monocytes in rheumatoid arthritis are highly adherent to cultured endothelium. Int Arch Allergy Immunol. 1995, 108: 211-223.
PubMed
Google Scholar
Okawa-Takatsuji M, Aotsuka S, Uwatoko S, Yokohari R, Inagaki K: Monocyte-mediated suppression of rheumatoid factor production in normal subjects. Clin Immunol Immunopathol. 1988, 46: 195-204.
PubMed
Google Scholar
Nagashima M, Yoshino S, Tanaka H: Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study. Rheumatol Int. 1998, 18: 113-118.
PubMed
Google Scholar
Kirkpatrick RB, Emery JG, Connor JR: Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages. Exp Cell Res. 1997, 237: 46-54. 10.1006/excr.1997.3764.
PubMed
Google Scholar
Krause SW, Rehli M, Andreesen R: Carboxypeptidase M as a marker of macrophage maturation. Immunol Rev. 1998, 161: 119-127.
PubMed
Google Scholar
Stout RD, Suttles J: T cell signaling of macrophage function in inflammatory disease. Front Biosci. 1997, 2: d197-206.
PubMed
Google Scholar
Dayer J-M, Burger D: Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention [commentary].
Lacraz S, Isler P, Vey E, Welgus HG, Dayer J-M: Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression. J Biol Chem. 1994, 269: 22027-22033.
PubMed
Google Scholar
Landis RC, Friedman ML, Fisher RI, Ellis TM: Induction of human monocyte IL-1 mRNA and secretion during anti-CD3 mitogenesis requires two distinct T cell-derived signals. J Immunol. 1991, 146: 128-135.
PubMed
Google Scholar
Parry SL, Sebbag M, Feldmann M, Brennan FM: Contact with T cells modulates monocyte IL-10 production: Role of T cell membrane TNF-alpha. J Immunol. 1997, 158: 3673-3681.
PubMed
Google Scholar
Sebbag M, Parry SL, Brennan FM, Feldmann M: Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis. Eur J Immunol. 1997, 27: 624-632.
PubMed
Google Scholar
Chomarat P, Rissoan MC, Pin JJ, Banchereau J, Miossec P: Contribution of IL-1, CD14, and CD13 in the increased IL-6 production induced by in vitro monocyte-synoviocyte interactions. J Immunol. 1995, 155: 3645-3652.
PubMed
Google Scholar
Janusz MJ, Hare M: Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metallo-proteinase-mediated connective tissue degradation. J Immunol. 1993, 150: 1922-1931.
PubMed
Google Scholar
Scott BB, Weisbrot LM, Greenwood JD: Rheumatoid arthritis synovial fibroblast and U937 macrophage/monocyte cell line interaction in cartilage degradation. Arthritis Rheum. 1997, 40: 490-498.
PubMed
Google Scholar
McInnes IB, Al-Mughales J, Field M: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med. 1996, 2: 175-182.
PubMed
Google Scholar
McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY: Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nature Med. 1997, 3: 189-195.
PubMed
Google Scholar
Badolato R, Ponzi AN, Millesimo M, Notarangelo LD, Musso T: Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood. 1997, 90: 2804-2809.
PubMed
Google Scholar
Jovanovic DV, DiBattista JA, Martel-Pelletier J: IL-17 stimulates the production and expression of proinflammatory cytokines, IL-1beta and TNF-alpha, by human macrophages. J Immunol. 1998, 160: 3513-3521.
PubMed
Google Scholar
Aarvak T, Chabaud M, Miossec P, Natvig JB: IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol. 1999, 162: 1246-1251.
PubMed
Google Scholar
Kotake S, Udagawa N, Takahashi N: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999, 103: 1345-1352.
PubMed
PubMed Central
Google Scholar
Shalom-Barak T, Quach J, Lotz M: Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF- kappaB. J Biol Chem. 1998, 273: 27467-27473.
PubMed
Google Scholar
Dinarello CA: Interleukin-18. Methods. 1999, 19: 121-132. 10.1006/meth.1999.0837.
PubMed
Google Scholar
Rodenburg RJ, Brinkhuis RF, Peek R: Expression of macrophage-derived chemokine (MDC) mRNA in macrophages is enhanced by interleukin-1beta, tumor necrosis factor alpha, and lipopolysaccharide. J Leukoc Biol. 1998, 63: 606-611.
PubMed
Google Scholar
Edwards CK, Zhou T, Zhang J: Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha. J Immunol. 1996, 157: 1758-1772.
PubMed
Google Scholar
Chatterjee D, Khoo KH: Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects. Glycobiology. 1998, 8: 113-120. 10.1093/glycob/8.2.113.
PubMed
Google Scholar
Yoshida A, Koide Y: Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages. Infect Immun. 1997, 65: 1953-1955.
PubMed
PubMed Central
Google Scholar
Bernardo J, Billingslea AM, Blumenthal RL: Differential responses of human mononuclear phagocytes to mycobacterial lipoarabinomannans: role of CD14 and the mannose receptor. Infect Immun. 1998, 66: 28-35.
PubMed
PubMed Central
Google Scholar
Linn ML, Aaskov JG, Suhrbier A: Antibody-dependent enhancement and persistence in macrophages of an arbovirus associated with arthritis. J Gen Virol. 1996, 77: 407-411.
PubMed
Google Scholar
Wilkerson MJ, Davis WC, Baszler TV, Cheevers WP: Immunopathology of chronic lentivirus-induced arthritis. Am J Pathol. 1995, 146: 1433-1443.
PubMed
PubMed Central
Google Scholar
Itescu S: Rheumatic aspects of acquired immunodeficiency syndrome. Curr Opin Rheumatol. 1996, 8: 346-353.
PubMed
Google Scholar
Takahashi Y, Murai C, Shibata S: Human parvovirus B19 as a causative agent for rheumatoid arthritis. Proc Natl Acad Sci USA. 1998, 95: 8227-8232.
PubMed
PubMed Central
Google Scholar
Cutolo M: Do sex hormones modulate the synovial macrophages in rheumatoid arthritis?. Ann Rheum Dis. 1997, 56: 281-284.
PubMed
PubMed Central
Google Scholar
Rittenhouse PA, Redei E: Thyroxine administration prevents streptococcal cell wall-induced inflammatory responses. Endocrinology. 1997, 138: 1434-1439.
PubMed
Google Scholar
Wilder RL, Elenkov IJ: Hormonal regulation of tumor necrosis factor-alpha, interleukin-12 and interleukin-10 production by activated macrophages. A disease-modifying mechanism in rheumatoid arthritis and systemic lupus erythematosus?. Ann N Y Acad Sci. 1999, 876: 14-31.
PubMed
Google Scholar
Miossec P, Naviliat M, Dupuy DA, Sany J, Banchereau J: Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. Arthritis Rheum. 1990, 33: 1180-1187.
PubMed
Google Scholar
Isomaki P, Luukkainen R, Saario R, Toivanen P, Punnonen J: Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum. 1996, 39: 386-395.
PubMed
Google Scholar
Hart PH, Hunt EK, Bonder CS, Watson CJ, Finlay-Jones JJ: Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10. J Immunol. 1996, 157: 3672-3680.
PubMed
Google Scholar
Allen JB, Wong HL, Costa GL, Bienkowski MJ, Wahl SM: Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis. J Immunol. 1993, 151: 4344-4351.
PubMed
Google Scholar
Sugiyama E, Taki H, Kuroda A, Bienkowski MJ, Wahl SM: Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I. Ann Rheum Dis. 1996, 55: 375-382.
PubMed
PubMed Central
Google Scholar
Kuroda A, Sugiyama E, Taki H, Mino T, Kobayashi M: Interleukin-4 inhibits the gene expression and biosynthesis of cytosolic phospholipase A2 in lipopolysaccharide stimulated U937 macrophage cell line and freshly prepared adherent rheumatoid synovial cells. Biochem Biophys Res Commun. 1997, 230: 40-43. 10.1006/bbrc.1996.5885.
PubMed
Google Scholar
Rocken M, Urban J, Shevach EM: Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J Exp Med. 1994, 179: 1885-1893.
PubMed
Google Scholar
Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature. 1996, 383: 787-793.
PubMed
Google Scholar
Kasama T, Strieter RM, Lukacs NW: Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest. 1995, 95: 2868-2876.
PubMed
PubMed Central
Google Scholar
Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M: Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994, 179: 1517-1527.
PubMed
Google Scholar
Keystone E, Wherry J, Grint P: IL-10 as a therapeutic strategy in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 1998, 24: 629-639.
PubMed
Google Scholar
Smeets TJ, Kraan MC, Versendaal J, Breedveld FC, Tak PP: Analysis of serial synovial biopsies in patients with rheumatoid arthritis: description of a control group without clinical improvement after treatment with interleukin 10 or placebo. J Rheumatol. 1999, 26: 2089-2093.
PubMed
Google Scholar
Hermann JA, Hall MA, Maini RN, Feldmann M, Brennan FM: Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1388-1397.
PubMed
Google Scholar
Trepicchio WL, Dorner AJ: Interleukin-11. A gp130 cytokine. Ann N Y Acad Sci. 1998, 856: 12-21.
PubMed
Google Scholar
Mino T, Sugiyama E, Taki H: Interleukin-1alpha and tumor necrosis factor alpha synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts. Arthritis Rheum. 1998, 41: 2004-2013.
PubMed
Google Scholar
Walmsley M, Butler DM, Marinova-Mutafchieva L, Feldmann M: An anti-inflammatory role for interleukin-11 in established murine collagen-induced arthritis. Immunology. 1998, 95: 31-37.
PubMed
PubMed Central
Google Scholar
Thornton S, Duwel LE, Boivin GP, Ma Y, Hirsch R: Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expression. Arthritis Rheum. 1999, 42: 1109-1118.
PubMed
Google Scholar
Schwertschlag US, Trepicchio WL, Dykstra KH: Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia. 1999, 13: 1307-1315. 10.1038/sj/leu/2401514.
PubMed
Google Scholar
Bessis N, Boissier MC, Ferrara P: Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur J Immunol. 1996, 26: 2399-2403.
PubMed
Google Scholar
Isomaki P, Luukkainen R, Toivanen P, Punnonen J: The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 1996, 39: 1693-1702.
PubMed
Google Scholar
Ogasawara H, Takeda-Hirokawa N, Sekigawa I: Inhibitory effect of interleukin-16 on interleukin-2 production by CD4+ T cells. Immunology. 1999, 96: 215-219. 10.1046/j.1365-2567.1999.00693.x.
PubMed
PubMed Central
Google Scholar
Franz JK, Kolb SA, Hummel KM: Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis. Eur J Immunol. 1998, 28: 2661-2671. 10.1002/(SICI)1521-4141(199809)28:09<2661::AID-IMMU2661>3.0.CO;2-N.
PubMed
Google Scholar
Klimiuk PA, Goronzy JJ, Weyand CM: IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis. J Immunol. 1999, 162: 4293-4299.
PubMed
Google Scholar
Dayer J-M, Fenner H: The role of cytokines and their inhibitors in arthritis. Baillieres Clin Rheumatol. 1992, 6: 485-516.
PubMed
Google Scholar
Firestein GS, Alvaro-Gracia JM, Maki R: Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990, 144: 3347-3353.
PubMed
Google Scholar
Müssener A, Klareskog L, Lorentzen JC, Kleinau S: TNF-alpha dominates cytokine mRNA expression in lymphoid tissues of rats developing collagen- and oil-induced arthritis. Scand J Immunol. 1995, 42: 128-134.
PubMed
Google Scholar
Schmidt-Weber CB, Pohlers D, Siegling A: Cytokine gene activation in synovial membrane, regional lymph nodes, and spleen during the course of rat adjuvant arthritis. Cell Immunol. 1999, 195: 53-65. 10.1006/cimm.1999.1509.
PubMed
Google Scholar
Schädlich H, Ermann J, Biskop M: Anti-inflammatory effects of systemic anti-tumour necrosis factor alpha treatment in human/murine SCID arthritis. Ann RheumDis. 1999, 58: 428-434.
Google Scholar
Henderson B, Pettipher ER: Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo. Clin Exp Immunol. 1989, 75: 306-310.
PubMed
PubMed Central
Google Scholar
Probert L, Plows D, Kontogeorgos G, Kollias G: The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol. 1995, 25: 1794-1797.
PubMed
Google Scholar
Neidel J, Schulze M, Lindschau J: Association between degree of bone-erosion and synovial fluid-levels of tumor necrosis factor alpha in the knee-joints of patients with rheumatoid arthritis. Inflamm Res. 1995, 44: 217-221.
PubMed
Google Scholar
Grell M, Douni E, Wajant H: The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 1995, 83: 793-802.
PubMed
Google Scholar
Georgopoulos S, Plows D, Kollias G: Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice. J Inflamm. 1996, 46: 86-97.
PubMed
Google Scholar
Alexopoulou L, Pasparakis M, Kollias G: A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur J Immunol. 1997, 27: 2588-2592.
PubMed
Google Scholar
Gearing AJ, Beckett P, Christodoulou M: Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature. 1994, 370: 555-557.
PubMed
Google Scholar
Roux-Lombard P, Punzi L, Hasler F: Soluble tumor necrosis factor receptors in human inflammatory synovial fluids. Arthritis Rheum. 1993, 36: 485-489.
PubMed
Google Scholar
Grell M, Wajant H, Zimmermann G, Scheurich P: The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc Natl Acad Sci USA. 1998, 95: 570-575.
PubMed
PubMed Central
Google Scholar
Su X, Zhou T, Yang P, Edwards CK, Mountz JD: Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor. Arthritis Rheum. 1998, 41: 139-149.
PubMed
Google Scholar
Ulfgren AK, Andersson U, Engstrom M, Klareskog L, Maini RN, Taylor PC: Systemic anti-TNFα therapy in rheumatoid arthritis (RA) down-regulates synovial TNFα synthesis. Arthritis Rheum. 1999, 42: S94-.
Google Scholar
Kavanaugh A, Schaible T, deWoody K: Long-term follow-up of patients treated with infliximab (anti-TNFα antibody) in clinical trials. Arthritis Rheum. 1999, 42: S401-.
Google Scholar
Rau R, Herborn G, Sander O: Long-term treatment with the fully human anti-TNF-antibody D2E7 slows radiographic disease progression in rheumatoid arthritis. Arthritis Rheum. 1999, 42: S400-.
Google Scholar
Lipsky P, St Clair W, Furst D: 54-week clinical and radiographic results from the ATTRACT trial: a phase III study of Infliximab (Remicade TM) in patients with active RA despite methotrexate. Arthritis Rheum. 1999, 42: S401-.
Google Scholar
Mackay F, Loetscher H, Stueber D, Gehr G, Lesslauer W: Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J Exp Med. 1993, 177: 1277-1286.
PubMed
Google Scholar
Paleolog E: Target effector role of vascular endothelium in the inflammatory response: Insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis. Mol Pathol. 1997, 50: 225-233.
PubMed
PubMed Central
Google Scholar
Wood NC, Dickens E, Symons JA, Duff GW: In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis. Clin Immunol Immunopathol. 1992, 62: 295-300.
PubMed
Google Scholar
von den Hoff H, de Koning M, van Kampen J, van der Korst J: Interleukin-1 reversibly inhibits the synthesis of biglycan and decorin in intact articular cartilage in culture. J Rheumatol. 1995, 22: 1520-1526.
PubMed
Google Scholar
Assuma R, Oates T, Cochran D, Amar S, Graves DT: IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998, 160: 403-409.
PubMed
Google Scholar
Bedard PA, Golds EE: Cytokine-induced expression of mRNAs for chemotactic factors in human synovial cells and fibroblasts. J Cell Physiol. 1993, 154: 433-441.
PubMed
Google Scholar
Loetscher P, Dewald B, Baggiolini M, Seitz M: Monocyte chemoat-tractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs. Cytokine. 1994, 6: 162-170.
PubMed
Google Scholar
Peichl P, Ceska M, Effenberger F: Presence of NAP-1/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis. Scand J Immunol. 1991, 34: 333-339.
PubMed
Google Scholar
Koch AE, Polverini PJ, Kunkel SL: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science. 1992, 258: 1798-1801.
PubMed
Google Scholar
Campion GV, Lebsack ME, Lookabaugh J, Gordon G, Catalano M: Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum. 1996, 39: 1092-1101.
PubMed
Google Scholar
Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J: Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988, 31: 784-788.
PubMed
Google Scholar
Kotake S, Sato K, Kim KJ: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 1996, 11: 88-95.
PubMed
Google Scholar
Van De Loo FA, Kuiper S, van Enckevort FH, Arntz OJ, van den Berg WB: Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice. Am J Pathol. 1997, 151: 177-191.
PubMed
PubMed Central
Google Scholar
Wood NC, Symons JA, Dickens E, Duff GW: In situ hybridization of IL-6 in rheumatoid arthritis. Clin Exp Immunol. 1992, 87: 183-189.
PubMed
PubMed Central
Google Scholar
Szekanecz Z, Haines GK, Harlow LA: Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. Clin Immunol Immunopathol. 1995, 76: 187-194. 10.1006/clin.1995.1114.
PubMed
Google Scholar
Chu CQ, Field M, Abney E: Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction. Clin Exp Immunol. 1991, 86: 380-386.
PubMed
PubMed Central
Google Scholar
Wahl SM, Allen JB, Wong HL, Dougherty SF, Ellingsworth LR: Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium. J Immunol. 1990, 145: 2514-2519.
PubMed
Google Scholar
Edwards DR, Murphy G, Reynolds JJ: Transforming growth factor beta modulates the expression of collagenase and metallo-proteinase inhibitor. EMBO J. 1987, 6: 1899-1904.
PubMed
PubMed Central
Google Scholar
van der Zee E, Everts V, Beertsen W: Cytokines modulate routes of collagen breakdown. Review with special emphasis on mechanisms of collagen degradation in the periodontium and the burst hypothesis of periodontal disease progression. J Clin Periodontol. 1997, 24: 297-305.
PubMed
Google Scholar
Wahl SM, Allen JB, Welch GR, Wong HL: Transforming growth factor-beta in synovial fluids modulates Fc gamma RII (CD16) expression on mononuclear phagocytes. J Immunol. 1992, 148: 485-490.
PubMed
Google Scholar
Nieto A, Caliz R, Pascual M, Mataran L, Garcia S, Martin J: Involvement of Fcγ receptor IIIA genotypes in susceptibility to rheumatoid arthritis. Arthritis Rheum. 2000, 43: 735-739.
PubMed
Google Scholar
van Lent PLEM, van Vuuren AJ, Blom AR: Role of Fc receptor γ chain in inflammation and cartilage damage during experimental antigen-induced arthritis. Arthritis Rheum. 2000, 43: 740-752.
PubMed
Google Scholar
Wahl SM, Allen JB, Weeks BS, Wong HL, Klotman PE: Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes. Proc Natl Acad Sci USA. 1993, 90: 4577-4581.
PubMed
PubMed Central
Google Scholar
Suto TS, Fine LG, Shimizu F, Kitamura M: In vivo transfer of engineered macrophages into the glomerulus: endogenous TGF-beta-mediated defense against macrophage-induced glomerular cell activation. J Immunol. 1997, 159: 2476-2483.
PubMed
Google Scholar
Moldovan F, Pelletier JP, Hambor J, Cloutier JM, Martel-Pelletier J: Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: In vitro mimicking effect by transforming growth factor beta. Arthritis Rheum. 1997, 40: 1653-1661.
PubMed
Google Scholar
Alexander JP, Samples JR, Acott TS: Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr Eye Res. 1998, 17: 276-285.
PubMed
Google Scholar
Imai K, Hiramatsu A, Fukushima D, Pierschbacher MD, Okada Y: Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. Biochem J. 1997, 322: 809-814.
PubMed
PubMed Central
Google Scholar
Sakurai H, Kohsaka H, Liu MF: Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest. 1995, 96: 2357-2363.
PubMed
PubMed Central
Google Scholar
McInnes IB, Leung BP, Field M: Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med. 1996, 184: 1519-1524.
PubMed
Google Scholar
Amin AR, Attur MG, Thakker GD: A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA. 1996, 93: 14014-14019.
PubMed
PubMed Central
Google Scholar
Chae HJ, Park RK, Chung HT: Nitric oxide is a regulator of bone remodelling. J Pharm Pharmacol. 1997, 49: 897-902.
PubMed
Google Scholar
Bogdan C: The multiplex function of nitric oxide in (auto)immunity. J Exp Med. 1998, 187: 1361-1365.
PubMed
PubMed Central
Google Scholar
Hansen DWJ, Peterson KB, Trivedi M: 2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS). J Med Chem. 1998, 41: 1361-1366. 10.1021/jm9704715.
PubMed
Google Scholar
Miesel R, Murphy MP, Kröger H: Enhanced mitochondrial radical production in patients which rheumatoid arthritis correlates with elevated levels of tumor necrosis factor alpha in plasma. Free Radic Res. 1996, 25: 161-169.
PubMed
Google Scholar
Butler DM, Malfait AM, Mason LJ: DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition. J Immunol. 1997, 159: 2867-2876.
PubMed
Google Scholar
Kouskoff V, Korganow AS, Duchatelle V: Organ-specific disease provoked by systemic autoimmunity. Cell. 1996, 87: 811-822.
PubMed
Google Scholar
Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science. 1999, 286: 1732-1735. 10.1126/science.286.5445.1732.
PubMed
Google Scholar
Nakamura H, Igarashi M: Localization of gold in synovial membrane of rheumatoid arthritis treated with sodium aurothiomalate. Studies by electron microscope and electron probe x-ray microanalysis. Ann Rheum Dis. 1977, 36: 209-215.
PubMed
PubMed Central
Google Scholar
Seitz M, Loetscher P, Dewald B, Towbin H, Baggiolini M: In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs. J Rheumatol. 1997, 24: 1471-1476.
PubMed
Google Scholar
Koch AE, Burrows JC, Polverini PJ, Cho M, Leibovich SJ: Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity. Agents Actions. 1991, 34: 350-357.
PubMed
Google Scholar
Lewis EJ, Bishop J, Aspinall SJ: A simple inflammation model that distinguishes between the actions of anti-inflammatory and antirheumatic drugs. Inflamm Res. 1998, 47: 26-35. 10.1007/s000110050251.
PubMed
Google Scholar
Seitz M, Loetscher P, Dewald B: Methotrexate action in rheumatoid arthritis: Stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells. Br J Rheumatol. 1995, 34: 602-609.
PubMed
Google Scholar
Williams FM, Cohen PR, Arnett FC: Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis. J Am Acad Dermatol. 1998, 39: 359-362.
PubMed
Google Scholar
Clark P, Casas E, Tugwell P: Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. Ann Intern Med. 1993, 119: 1067-1071.
PubMed
Google Scholar
MacIntyre AC, Cutler DJ: Role of lysosomes in hepatic accumulation of chloroquine. J Pharm Sci. 1988, 77: 196-199.
PubMed
Google Scholar
Angel J, Colard O, Chevy F, Fournier C: Interleukin-1-mediated phospholipid breakdown and arachidonic acid release in human synovial cells. Arthritis Rheum. 1993, 36: 158-167.
PubMed
Google Scholar
Jeong JY, Jue DM: Chloroquine inhibits processing of tumor necrosis factor in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Immunol. 1997, 158: 4901-4907.
PubMed
Google Scholar
Amano Y, Lee SW, Allison AC: Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability. Mol Pharmacol. 1993, 43: 176-182.
PubMed
Google Scholar
Kalgutkar AS, Crews BC, Rowlinson SW: Aspirin-like molecules that covalently inactivate cyclooxygenase-2. Science. 1998, 280: 1268-1270.
PubMed
Google Scholar
Ross SE, Williams RO, Mason LJ: Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram. J Immunol. 1997, 159: 6253-6259.
PubMed
Google Scholar
Shackelford RE, Alford PB, Xue Y: Aspirin inhibits tumor necrosis factor alpha gene expression in murine tissue macrophages. Mol Pharmacol. 1997, 52: 421-429.
PubMed
Google Scholar
Schmidt-Weber CB, Rittig M, Buchner E: Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. J Leukoc Biol. 1996, 60: 230-244.
PubMed
Google Scholar
Oelzner P, Bräuer R, Henzgen S: Periarticular bone alterations in chronic antigen-induced arthritis: free and liposome-encapsulated clodronate prevent loss of bone mass in the secondary spongiosa. Clin Immunol Immunopathol. 1999, 90: 79-88.
Google Scholar
Sawada T, Hashimoto S, Furukawa H: Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper. Immunopharmacology. 1997, 35: 195-202. 10.1016/S0162-3109(96)00145-2.
PubMed
Google Scholar
Evans CH, Ghivizzani SC, Lechman ER: Lessons learned from gene transfer approaches.
Foxwell B, Browne K, Bondeson J: Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc Natl Acad Sci USA. 1998, 95: 8211-8215.
PubMed
PubMed Central
Google Scholar
Handel ML, McMorrow LB, Gravallese EM: Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 1995, 38: 1762-1770.
PubMed
Google Scholar
Handel ML: Transcription factors AP-1 and NF-kappa B: where steroids meet the gold standard of anti-rheumatic drugs. Inflamm Res. 1997, 46: 282-286. 10.1007/s000110050188.
PubMed
Google Scholar
Donnelly RP, Crofford LJ, Freeman SL: Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts. J Immunol. 1993, 151: 5603-5612.
PubMed
Google Scholar
Chomarat P, Banchereau J, Miossec P: Differential effects of interleukins 10 and 4 on the production of interleukin-6 by blood and synovium monocytes in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 1046-1054.
PubMed
Google Scholar
Wang P, Wu P, Siegel MI, Egan RW, Billah MM: Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem. 1995, 270: 9558-9563.
PubMed
Google Scholar
Bogdan C, Paik J, Vodovotz Y, Nathan C: Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J Biol Chem. 1992, 267: 23301-23308.
PubMed
Google Scholar
DeLuca HF, Zierold C: Mechanisms and functions of vitamin D. Nutr Rev. 1998, 56 (suppl): S4-S10.
Google Scholar
Cantorna MT, Woodward WD, Hayes CE, DeLuca HF: 1,25-dihy-droxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol. 1998, 160: 5314-5319.
PubMed
Google Scholar
Tsuji M, Fujii K, Nakano T, Nishii Y: 1 alpha-hydroxyvitamin D3 inhibits type II collagen-induced arthritis in rats. FEBS Lett. 1994, 337: 248-250.
PubMed
Google Scholar
Oelzner P, Müller A, Deschner F: Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis. Calcif Tissue Int. 1998, 62: 193-198. 10.1007/s002239900416.
PubMed
Google Scholar
Ito S, Nozawa S, Ishikawa H: Renal stones in patients with rheumatoid arthritis. J Rheumatol. 1997, 24: 2123-2128.
PubMed
Google Scholar
van Meurs JB, van Lent PL, Singer II: Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum. 1998, 41: 647-656.
PubMed
Google Scholar
Baragi VM, Renkiewicz RR, Jordan H: Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest. 1995, 96: 2454-2460.
PubMed
PubMed Central
Google Scholar
Lubberts E, Joosten LA, van den Bersselaar L: Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol. 1999, 163: 4546-4556.
PubMed
Google Scholar
Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB: Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. Lab Invest. 1998, 78: 133-142.
PubMed
Google Scholar
Sant SM, Suarez TM, Moalli MR: Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer. Hum Gene Ther. 1998, 9: 2735-2743.
PubMed
Google Scholar
Goossens PH, Schouten GJ, 't Hart BA: Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen- induced arthritis-affected rhesus monkeys. Hum Gene Ther. 1999, 10: 1139-1149. 10.1089/10430349950018139.
PubMed
Google Scholar
Guery L, Batteux F, Bessis N: Expression of fas ligand improves the effect of IL-4 in collagen-induced arthritis. Eur J Immunol. 2000, 30: 308-315. 10.1002/(SICI)1521-4141(200001)30:01<308::AID-IMMU308>3.3.CO;2-9.
PubMed
Google Scholar
Okamoto K, Asahara H, Kobayashi T: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther. 1998, 5: 331-338. 10.1038/sj/gt/3300597.
PubMed
Google Scholar
Muller-Ladner U, Evans CH, Franklin BN: Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum. 1999, 42: 490-497.
PubMed
Google Scholar