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Arthritis Research & Therapy

Open Access

Novel function of GATA-3, revealed by conditional deficient mice

  • IC Ho1,
  • SY Pai2 and
  • ML Truitt3
Arthritis Res Ther20035(Suppl 3):80

https://doi.org/10.1186/ar881

Published: 12 September 2003

Keywords

Public HealthZincZinc FingerDeficient MouseAdult Animal

GATA-3 is a zinc finger protein that is preferentially expressed in T cells in adult animals. Previous studies have shown that GATA-3 is essential for the transition from common lymphoid precursors to the most immature thymocytes. In addition, GATA-3 is selectively expressed in Th2 cells. Overexpression of GATA-3 forced developing Th1 cells to produce Th2 cytokines, including IL-4, IL-5, and IL-13. However, it remains unclear whether GATA-3 is also important at the later stages of T-cell development. Nor do we understand whether GATA-3 is essential for the differentiation of Th2 cells or for the maintenance of the Th2 phenotype. The lack of GATA-3-deficient mice or T cells has precluded further studies to address these important questions. We have recently generated conditional GATA-3-deficient mice. Studies on the conditional GATA-3-deficient mice has uncovered several novel roles of GATA-3 in regulating the development and function of T cells.

Authors’ Affiliations

(1)
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, USA
(2)
Dana Farber Cancer Institute, Boston, USA
(3)
Brigham and Women's Hospital, Boston, USA

Copyright

© BioMed Central Ltd 2003

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