Volume 5 Supplement 3

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

Open Access

IL-12 priming during initial antigen contact increases generation of effector and memory CD8 T cells by changing properties

  • J Chang1,
  • J-H Cho1,
  • S-Y Choi1,
  • S-J Ha1 and
  • Y-C Sung1
Arthritis Res Ther20035(Suppl 3):93

https://doi.org/10.1186/ar894

Published: 12 September 2003

Initial antigen contact is known to trigger an instructive developmental program by which naive CD8 T cells differentiate into effector and memory cells. However, it remains to be determined how initial cytokine signals act on the generation of effector and memory CD8 T cells. Here, we demonstrate that IL-12 treatment during initial antigen contact results in the significant increase of both primary and memory CD8 T-cell populations. These quantitative differences were associated with qualitative changes in CD8 T cells directly caused by IL-12. Initial IL-12 priming also improved the intrinsic properties of memory CD8 T cells, leading to better protective immunity and vaccine-induced memory CD8 T-cell responses. Our results suggest that IL-12 is an important regulatory factor for developmental programming of CD8 T cells. Future application of IL-12 priming will be discussed.

Authors’ Affiliations

(1)
Department of Life Science, Pohang University of Science and Technology

Copyright

© The Author(s) 2003

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