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  • Open Access

Synoviolin as a novel pathogenic factor for arthropathy

  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 3,
  • 1 and
  • 1
Arthritis Res Ther20035 (Suppl 3) :144

https://doi.org/10.1186/ar945

  • Published:

Keywords

  • Public Health
  • Rheumatoid Arthritis
  • Arthritis
  • Cell Outgrowth
  • Therapeutic Strategy

Rheumatoid arthritis (RA) is one of the most critical articular diseases with synovial hyperplasia followed by impairment of quality of life. However, the mechanism(s) that regulate synovial cell outgrowth is not fully understood. To clarify its mechanism(s), we carried out immunoscreening using antirheumatoid synovial cell antibody, and identified and cloned Synoviolin. Synoviolin was highly expressed in the rheumatoid synovium, and mice overexpressing this protein developed spontaneous arthropathy. Conversely, synoviolin+/- mice were resistant to collagen-induced arthritis by enhanced apoptosis of synovial cells. We conclude that Synoviolin is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. Our findings provide a new pathogenetic model of RA, and suggest that Synoviolin could be targeted as a therapeutic strategy for RA.

Authors’ Affiliations

(1)
Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
(2)
Institute of Applied Biochemistry and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
(3)
Department of Dermatology and Laboratory of Molecular Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

Copyright

© BioMed Central Ltd 2003

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