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Table 1 Highly differentially expressed genes grouped according to function

From: Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis

Gene symbol Ctrl (Log 2 AFU) a Day 0 to 3 b week 1 to 2 c Week 3 to 4 d Decline e Localisation Ar vs. N f Ar vs. N g
Saa3 6.8 44.1 26.2 7.8 2.7 Plasma 18.0 2.0
Mmp3 7.2 23.1 11.9 5.2 2.9 Synovium 10.1 5.3
Mmp13 7.6 13.2 17.3 8.9 4.5 Synovium 3.5 2.3
Timp1 7.5 19.4 9.3 5.3 3.4 Synovium 1.9 3.5
Ctsk 7.8 11.0 11.7 7.6 4.8 Osteoclasts 2.8 1.7
Atp6v0d2 6.97 9.03 7.18 5.94 3.67 Endosome 1.5 1.0
Postn 8.5 10.3 9.8 5.0 2.5 Osteoblasts 4.5 1.0
Krtdap 7.6 0.1 0.2 4.5 14.1 Skin* 0.4 1.1
Lce1a1/1a2 8.2 0.1 0.1 2.8 7.9 Skin NA 1.0
Lor 8.4 0.1 0.2 3.7 5.4 Skin* 0.6 1.1
Krt1/2/5/14 7.8 0.1 0.2 3.4 10.3 Skin* 0.8 1.0
Mt4 7.40 0.32 0.36 4.63 19.15 Epithelia* 0.8 1.0
Myl2 10.5 0.1 0.8 1.0 1.0 Muscle 0.2 0.6
Pygm 10.8 0.1 0.4 0.4 0.6 Muscle 0.5 0.7
Casq1 10.78 0.12 0.85 0.57 0.72 Muscle 0.5 0.7
Myh4 11.96 0.13 0.45 0.31 0.43 Muscle 0.3 0.9
Ckm 10.78 0.14 0.44 0.46 0.76 Muscle 0.6 0.7
  1. aMean log2 expression in non-induced control mice. Mean fold change in comparison to control: bon day 0 to 3, cin week 1 to 2, din week 3 to 4, ein the declining disease phase. Fold change of gene expression in arthritic joints from the fTNFα overexpressing model versus control [7], and the gPGIA arthritis model versus control [8], *Differentially expressed epidermal specific genes in arthritic joints from the present study and the TNFα overexpressing model [7]. Ctrl, control; PGIA, proteoglycan-induced arthritis; TNFα, tumour necrosis factor alpha.