Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis

Table 1 Highly differentially expressed genes grouped according to function

Gene symbol	Ctrl (Log ₂ AFU) ^a	Day 0 to 3 ^b	week 1 to 2 ^c	Week 3 to 4 ^d	Decline ^e	Localisation	Ar vs. N ^f	Ar vs. N ^g
Saa3	6.8	44.1	26.2	7.8	2.7	Plasma	18.0	2.0
Mmp3	7.2	23.1	11.9	5.2	2.9	Synovium	10.1	5.3
Mmp13	7.6	13.2	17.3	8.9	4.5	Synovium	3.5	2.3
Timp1	7.5	19.4	9.3	5.3	3.4	Synovium	1.9	3.5
Ctsk	7.8	11.0	11.7	7.6	4.8	Osteoclasts	2.8	1.7
Atp6v0d2	6.97	9.03	7.18	5.94	3.67	Endosome	1.5	1.0
Postn	8.5	10.3	9.8	5.0	2.5	Osteoblasts	4.5	1.0
Krtdap	7.6	0.1	0.2	4.5	14.1	Skin*	0.4	1.1
Lce1a1/1a2	8.2	0.1	0.1	2.8	7.9	Skin	NA	1.0
Lor	8.4	0.1	0.2	3.7	5.4	Skin*	0.6	1.1
Krt1/2/5/14	7.8	0.1	0.2	3.4	10.3	Skin*	0.8	1.0
Mt4	7.40	0.32	0.36	4.63	19.15	Epithelia*	0.8	1.0
Myl2	10.5	0.1	0.8	1.0	1.0	Muscle	0.2	0.6
Pygm	10.8	0.1	0.4	0.4	0.6	Muscle	0.5	0.7
Casq1	10.78	0.12	0.85	0.57	0.72	Muscle	0.5	0.7
Myh4	11.96	0.13	0.45	0.31	0.43	Muscle	0.3	0.9
Ckm	10.78	0.14	0.44	0.46	0.76	Muscle	0.6	0.7

^aMean log2 expression in non-induced control mice. Mean fold change in comparison to control: ^bon day 0 to 3, ^cin week 1 to 2, ^din week 3 to 4, ^ein the declining disease phase. Fold change of gene expression in arthritic joints from the ^fTNFα overexpressing model versus control [7], and the ^gPGIA arthritis model versus control [8], *Differentially expressed epidermal specific genes in arthritic joints from the present study and the TNFα overexpressing model [7]. Ctrl, control; PGIA, proteoglycan-induced arthritis; TNFα, tumour necrosis factor alpha.

ISSN: 1478-6362