Rasch EK, Hirsch R, Paulose-Ram R, Hochberg MC. Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: Effect of different methods of case classification. Arthritis Rheum. 2003;48:917–26.
Article
PubMed
Google Scholar
Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81:646–56.
PubMed Central
PubMed
Google Scholar
Mishto M, Santoro A, Bellavista E, Bonafé M, Monti D, Franceschi C. Immunoproteasomes and immunosenescence. Ageing Res Rev. 2003;2:419–32 [Proteolysis in Ageing and Age Related Disease].
Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: Senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther. 2004;6:131–9.
Article
PubMed Central
CAS
PubMed
Google Scholar
Alberti S, Cevenini E, Ostan R, Capri M, Salvioli S, Bucci L, et al. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech Ageing Dev. 2006;127:560–6.
Article
CAS
PubMed
Google Scholar
Innala L, Berglin E, Möller B, Ljung L, Smedby T, Södergren A, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2014;16:R94.
Article
PubMed Central
PubMed
Google Scholar
Bukhari M, Lunt M, Barton A, Bunn D, Silman A, Symmons D. Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis. Ann Rheum Dis. 2007;66:389–93.
Article
PubMed Central
PubMed
Google Scholar
Calvo-Alén J, Corrales A, Sánchez-Andrada S, Fernández-Echevarría MA, Peña JL, Rodríguez-Valverde V. Outcome of late-onset rheumatoid arthritis. Clin Rheumatol. 2005;24:485–9.
Article
PubMed
Google Scholar
Khanna D, Ranganath VK, FitzGerald J, Park GS, Altman RD, Elashoff D, et al. Increased radiographic damage scores at the onset of seropositive rheumatoid arthritis in older patients are associated with osteoarthritis of the hands, but not with more rapid progression of damage. Arthritis Rheum. 2005;52:2284–92.
Article
PubMed
Google Scholar
Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol. 2001;28:1809–16.
CAS
PubMed
Google Scholar
Van der Heijde DM, van Riel PL, van Leeuwen MA, van’t Hof MA, van Rijswijk MH, van de Putte LB. Older versus younger onset rheumatoid arthritis: results at onset and after 2 years of a prospective follow up study of early rheumatoid arthritis. J Rheumatol. 1991;18:1285–9.
PubMed
Google Scholar
Pease CT, Bhakta BB, Devlin J, Emery P. Does the age of onset of rheumatoid arthritis influence phenotype? A prospective study of outcome and prognostic factors. Rheumatology. 1999;38:228–34.
Article
CAS
PubMed
Google Scholar
Hellier J-P, Eliaou J-F, Daurès J-P, Sany J, Combe B. HLA-DRB1 genes and patients with late onset rheumatoid arthritis. Ann Rheum Dis. 2001;60:531–3.
Article
PubMed Central
CAS
PubMed
Google Scholar
El-Labban AS, Omar HASA, EL-Shereif RR, Ali F, El-Mansoury TM. Pattern of young and old onset rheumatoid arthritis (YORA and EORA) among a group of Egyptian patients with rheumatoid arthritis. Clin Med Insights Arthritis Musculoskelet Disord. 2010;3:25–31.
Article
PubMed Central
PubMed
Google Scholar
Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, et al. The effects of smoking and shared epitope on the production of ACPA and RF in a Japanese adult population: The Nagahama Study. Arthritis Care Res. 2014;66:1818–27.
Article
CAS
Google Scholar
Tamas M-M, Felea I, Rednic S. How much difference does the age at onset make in early arthritis patients? Comparison between the ACR 1987 and the ACR/EULAR 2010 classification criteria for rheumatoid arthritis at the time of diagnosis. Rheumatol Int. 2013;33:2881–4.
Article
PubMed
Google Scholar
Chen D-Y, Hsieh T-Y, Chen Y-M, Hsieh C-W, Lan J-L, Lin F-J. Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease. Gerontology. 2009;55:250–8.
Article
CAS
PubMed
Google Scholar
Radovits BJ, Fransen J, van Riel PLCM, Laan RFJM. Influence of age and gender on the 28-joint Disease Activity Score (DAS28) in rheumatoid arthritis. Ann Rheum Dis. 2008;67:1127–31.
Article
CAS
PubMed
Google Scholar
Cho S-K, Sung Y-K, Choi C-B, Cha H-S, Choe J-Y, Chung WT, et al. Do patients with elderly-onset rheumatoid arthritis have severe functional disability? Semin Arthritis Rheum. 2012;42:23–31.
Article
PubMed
Google Scholar
Turkcapar N, Demir O, Atli T, Kopuk M, Turgay M, Kinikli G, et al. Late onset rheumatoid arthritis: clinical and laboratory comparisons with younger onset patients. Arch Gerontol Geriatr. 2006;42:225–31.
Article
PubMed
Google Scholar
Krabben A, Stomp W, Huizinga TWJ, Heijde D van der, Bloem JL, Reijnierse M et al. Concordance between inflammation at physical examination and on MRI in patients with early arthritis. Ann Rheum Dis. 2015:74:506–12. doi: http://dx.doi.org/10/1136/annrheumdis-2013-204005.
Krabben A, Stomp W, van Nies JAB, Huizinga TWJ, van der Heijde D, Bloem JL, et al. MRI-detected subclinical joint inflammation is associated with radiographic progression. Ann Rheum Dis. 2014;73:2034–7.
Article
CAS
PubMed
Google Scholar
de Rooy DPC, van der Linden MPM, Knevel R, Huizinga TWJ, van der Helm Mil AHM. Predicting arthritis outcomes–what can be learned from the Leiden Early Arthritis Clinic? Rheumatology. 2011;50:93–100.
Article
PubMed
Google Scholar
Sharp JT, Wolfe F, Mitchell DM, Bloch DA. The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease. Arthritis Rheum. 1991;34:660–8.
Article
CAS
PubMed
Google Scholar
Innala L, Kokkonen H, Eriksson C, Jidell E, Berglin E, Rantapää-Dahlqvist S. Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides. J Rheumatol. 2008;35:1002–8.
PubMed
Google Scholar
Fex E, Jonsson K, Johnson U, Eberhardt K. Development of radiographic damage during the first 5–6 yr of rheumatoid arthritis. A prospective follow-up study of a Swedish cohort. Rheumatology. 1996;35:1106–15.
Article
CAS
Google Scholar
Knevel R, Tsonaka R, le Cessie S, van der Linden M, Huizinga T, van der Heijde D, et al. Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis. Scand J Rheumatol. 2013;42:182–9.
Article
CAS
PubMed
Google Scholar
Østergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, et al. OMERACT rheumatoid arthritis magnetic resonance imaging studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol. 2003;30:1385–6.
PubMed
Google Scholar
Haavardsholm EA, Østergaard M, Ejbjerg BJ, Kvan NP, Kvien TK. Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study. Ann Rheum Dis. 2007;66:1216–20.
Article
PubMed Central
PubMed
Google Scholar
Baan H, Bezooijen R, Avenarius JKA, Dubbeldam R, Drossaers-Bakker WK, van de Laar MAFJ. Magnetic resonance imaging of the rheumatic foot according to the RAMRIS system is reliable. J Rheumatol. 2011;38:1003–8.
Article
PubMed
Google Scholar
Knevel R, de Rooy DPC, Zhernakova A, Gröndal G, Krabben A, Steinsson K, et al. Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum. 2013;65:1684–93.
Article
CAS
PubMed
Google Scholar
Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh). 1977;18:481–91.
CAS
Google Scholar
Larsen A. How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol. 1995;22:1974–5.
CAS
PubMed
Google Scholar
Knevel R, Krabben A, Brouwer E, Posthumus MD, Wilson AG, Lindqvist E, et al. Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study. Ann Rheum Dis. 2012;71:1651–7.
Article
CAS
PubMed
Google Scholar
Rau R, Herborn G. A modified version of Larsen’s scoring method to assess radiologic changes in rheumatoid arthritis. J Rheumatol. 1995;22:1976–82.
CAS
PubMed
Google Scholar
Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173–82.
Article
CAS
PubMed
Google Scholar
Van der Linden MPM, le Cessie S, Raza K, van der Woude D, Knevel R, Huizinga TWJ, et al. Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheum. 2010;62:3537–46.
Article
PubMed
Google Scholar
Nies JAB van, Krabben A, Schoones JW, Huizinga TWJ, Kloppenburg M, Mil AHM van der H. What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann Rheum Dis 2014;73:861-70. doi: 10.1136/annrheumdis-2012-203130.
Haavardsholm EA, Bøyesen P, Østergaard M, Schildvold A, Kvien TK. Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression. Ann Rheum Dis. 2008;67:794–800.
Article
CAS
PubMed
Google Scholar
Kuijper TM, Luime JJ, Alves C, Barendregt PJ, van Zeben J, Bindels PJE, et al. Quality of life and health care use in patients with arthralgias without synovitis compared with patients diagnosed with early rheumatoid arthritis: data from an early arthritis cohort. Arthritis Care Res. 2014;66:379–86.
Article
Google Scholar
Salaffi F, Carotti M, Gasparini S, Intorcia M, Grassi W. The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people. Health Qual Life Outcomes. 2009;7:25.
Article
PubMed Central
PubMed
Google Scholar
Mangnus L, Schoones JW, van der Helm-van Mil AHM. FRI0210 What is the prevalence of MRI-detected features in small joints in the general population? A literature review. Ann Rheum Dis. 2014;73:458–8.
Article
Google Scholar
Fraenkel L, Rabidou N, Dhar R. Are rheumatologists’ treatment decisions influenced by patients’ age? Rheumatol Oxf Engl. 2006;45:1555–7.
Article
CAS
Google Scholar
Radovits BJ, Fransen J, Eijsbouts A, van Riel PLCM, Laan RFJM. Missed opportunities in the treatment of elderly patients with rheumatoid arthritis. Rheumatology. 2009;48:906–10.
Article
PubMed
Google Scholar
Mueller RB, Kaegi T, Finckh A, Haile SR, Schulze-Koops H, von Kempis J. Is radiographic progression of late-onset rheumatoid arthritis different from young-onset rheumatoid arthritis? Results from the Swiss prospective observational cohort. Rheumatology. 2014;53:671–7.
Article
PubMed
Google Scholar
Huscher D, Sengler C, Gromnica-Ihle E, Bischoff S, Eidner T, Ochs W, et al. Clinical presentation, burden of disease and treatment in young-onset and late-onset rheumatoid arthritis: a matched-pairs analysis taking age and disease duration into account. Clin Exp Rheumatol. 2013;31:256–62.
PubMed
Google Scholar
Harrison MJ, Kim CA, Silverberg M, Paget SA. Does age bias the aggressive treatment of elderly patients with rheumatoid arthritis? J Rheumatol. 2005;32:1243–8.
CAS
PubMed
Google Scholar