Viatte S, Plant D, Raychaudhuri S. Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol. 2013;9:141–53.
Article
PubMed Central
CAS
PubMed
Google Scholar
Karlson E, Lee I, Cook N, Manson J, Buring J, Hennekens C. A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. Arthritis Rheum. 1999;42:910–7.
Article
CAS
PubMed
Google Scholar
Helmick C, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I Arthritis Rheum. 2008;58:15–25.
Article
PubMed
Google Scholar
Almohmeed Y, Avenell A, Aucott L, Vickers MA. Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis. PLoS One. 2013;8, e61110. doi:10.1371/journal.pone.0061110.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hanlon P, Avenell A, Aucott L, Vickers M. Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus. Arthritis Res Ther. 2014;16:R3.
Article
PubMed Central
PubMed
Google Scholar
Zhang L, Nikkari S, Skurnik M, Ziegler T, Luukkainen R, Möttönen T, et al. Detection of herpesviruses by polymerase chain reaction in lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1993;36:1080–6.
Article
CAS
PubMed
Google Scholar
Balandraud N, Meynard JB, Auger I, Sovran H, Mugnier B, Reviron D, et al. Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: Accurate quantification using real-time polymerase chain reaction. Arthritis Rheum. 2003;48:1223–8.
Article
CAS
PubMed
Google Scholar
Alspaugh M, Jensen F, Rabin H, Tan E. Lymphocytes transformed by Epstein-Barr virus. Induction of nuclear antigen reactive with antibody in rheumatoid arthritis. J Exp Med. 1978;147:1018–27.
Article
CAS
PubMed
Google Scholar
Roudier J, Petersen J, Rhodes G, Luka J, Carson D. Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. Proc Natl Acad Sci. 1989;86:5104–8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Birkenfeld P, Haratz N, Klein G, Sultizeanu D. Cross-reactivity between the EBNA-1 p107 peptide, collagen, and keratin: Implications for the pathogenesis of rheumatoid arthritis. Clin Immunol Immunopathol. 1990;54:14–25.
Article
CAS
PubMed
Google Scholar
Scotet E, David-Ameline J, Peyrat MA, Moreau-Aubry A, Pinczon D, Lim A, et al. T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis. J Exper Med. 1996;184:1791–800.
Article
CAS
Google Scholar
Pender M. The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis. Neuroscientist. 2011;17:351–67.
Article
PubMed Central
CAS
PubMed
Google Scholar
Van Noort J, Bajramovic J, Plomp A, Van Stipdonk M. Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol. 2000;105:46–57.
Article
PubMed
Google Scholar
Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Cinque P, et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med. 2007;204:2899–912.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pender M. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases. Trends in Immunol. 2003;24:584–8.
Article
CAS
Google Scholar
Barton E, White DW, Cathelyn JS, Brett-McClellan KA, Engle M, Diamond MS. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature. 2007;447:326–9.
Article
CAS
PubMed
Google Scholar
Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. PLoS Negl Trop Dis. 2013;7, e2195.
Article
Google Scholar
Us T, Cetin E, Kaşifoğlu N, Kaşifoğlu T, Akgün Y. Investigation of Epstein-Barr virus and herpes simplex virus markers by serological and molecular methods in patients with rheumatoid arthritis and systemic lupus erythematosus. Mikrobiyol Bul. 2011;45:677–83.
PubMed
Google Scholar
Zhang X, Li B, Liu Y, Jiang M. Clinical study on antibodies against EBV in sera of patients with rheumatoid arthritis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999;21:8–12.
CAS
PubMed
Google Scholar
Higgins J, Thompson S, Deeks J, Altman D. Measuring inconsistency in meta-analyses. Br Med J. 2003;327:557–60.
Article
Google Scholar
Thomas P, Pearson G. Antibodies to Epstein-Barr viral antigens in a Mexican population with rheumatoid arthritis. Rev Int Rhumatol. 1982;12:441–4.
Google Scholar
Alspaugh M, Henle G, Lennette E, Henle W. Elevated levels of antibodies to Epstein-Barr virus antigens in sera and synovial fluids of patients with rheumatoid arthritis. J Clin Invest. 1981;67:1134–40.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ferrell P, Aitcheson C, Pearson G, Tan E. Seroepidemiological study of relationships between Epstein-Barr virus and rheumatoid arthritis. J Clin Invest. 1981;67:681–7.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lunemann J, Frey O, Eidner T, Baier M, Roberts S, Sashihara J. Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis. J Immunol. 2008;181:991–1000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Saal J, Krimmel M, Steidle M, Gerneth F, Wagner S, Fritz P. Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope. Arthritis Rheum. 1999;42:1485–96.
Article
CAS
PubMed
Google Scholar
Yazbek M, Barros-Mazon Sd, Rossi CL, Londe AC, Costallat LT, Bertolo MB. Association analysis of anti-Epstein-Barr nuclear antigen-1 antibodies, anti-cyclic citrullinated peptide antibodies, the shared epitope and smoking status in Brazilian patients with rheumatoid arthritis. Clinics (Sao Paulo). 2011;66:1401–6.
Mousavi-Jazi M, Boström L, Lövmark C, Linde A, Brytting M, Sundqvist VA. Infrequent detection of cytomegalovirus and Epstein-Barr virus DNA in synovial membrane of patients with rheumatoid arthritis. J Rheumatol. 1998;25:623–8.
CAS
PubMed
Google Scholar
Blaschke S, Schwarz G, Moneke D, Binder L, Müller G, Reuss-Borst M. Epstein-Barr virus infection in peripheral blood mononuclear cells, synovial fluid cells, and synovial membranes of patients with rheumatoid arthritis. J Rheumatol. 2000;27:866–73.
CAS
PubMed
Google Scholar
Venables P, Lindsay R, Erhardt C, Maini R, Edwards J. Titres of antibodies to RANA in rheumatoid arthritis and normal sera. Arthritis Rheum. 1981;24:1459–64.
Article
CAS
PubMed
Google Scholar
Venables P, Ross MG, Charles PJ, Melsom RD, Griffiths PD, Maini RN. A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome. Ann Rheum Dis. 1985;44:742–6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sculley T, Pope J, Hazelton R. Correlation between the presence of antibodies to the Epstein-Barr virus nuclear antigen type 2 and antibodies to the rheumatoid arthritis nuclear antigen in patients with rheumatoid arthritis. Arthritis Rheum. 1986;29:964–70.
Article
CAS
PubMed
Google Scholar
Shirodaria P, Haire M, Fleming E, Merrett JD, Hawkins SA, Roberts SD. Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis. Arch Neurol. 1987;44:1237–41.
Article
CAS
PubMed
Google Scholar
Silverman S, Schumacher HR. Antibodies to Epstein-Barr viral antigens in early rheumatoid arthritis. Arthritis Rheum. 1981;24:1465–8.
Article
Google Scholar
Ng K, Brown K, Perry J, Holborow E. Anti-RANA antibody: a marker for seronegative and seropositive rheumatoid arthritis. Lancet. 1980;1:447–9.
Article
CAS
PubMed
Google Scholar
Musiani M, Zerbini M, Ferri S, Plazzi M, Gentilomi G, La Placa M. Comparison of the immune response to Epstein-Barr virus and cytomegalovirus in sera and synovial fluids of patients with rheumatoid arthritis. Ann Rheum Dis. 1987;46:837–42.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yao Y, Rickinson A, Gaston J, Epstein M. Disturbance of the Epstein-Barr virus-host balance in rheumatoid arthritis patients: a quantitative study. Clin Exp Immunol. 1986;64:302–10.
PubMed Central
CAS
PubMed
Google Scholar
Phillips P, Waxman J, Hirshaut Y, Kaplan M. Virus antibody levels and delayed hypersensitivity in rheumatoid arthritis. Ann Rheum Dis. 1976;35:152–4.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nakabayashi K, Saito M, Nagasawa T, Takada M. Antibodies to rheumatoid arthritis nuclear antigen (RANA) in Japanese patients with rheumatoid arthritis. Rheumatol Int. 1985;5:61–7.
Article
CAS
PubMed
Google Scholar
Youinou P, Buisson M, Berthelot JM, Jamin C, Le Goff P, Genoulaz O, et al. Anti-Epstein-Barr virus-nuclear antigen-1, -2A and -2B antibodies in rheumatoid arthritis patients and their relatives. Autoimmunity. 1992;13:225–31.
Article
CAS
PubMed
Google Scholar
Draborg A, Jørgensen JM, Müller H, Nielsen CT, Jacobsen S, Iversen LV, et al. Epstein–Barr virus early antigen diffuse (EBV-EA/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients. Scand J Rheumatol. 2012;41:280–9.
Article
CAS
PubMed
Google Scholar
Jørgensen KT, Wiik A, Pedersen M, Hedegaard CJ, Vestergaard BF, Gislefoss RE, et al. Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case–control study nested in a cohort of Norwegian blood donors. Ann Rheum Dis. 2008;6:860–6.
Article
Google Scholar
Davies J, Mackay I, Rowley M. Rheumatoid arthritis sera react with a phage-displayed peptide selected by a monoclonal antibody to type II collagen that has homology to EBNA-1. Autoimmunity. 1999;30:53–9.
Article
CAS
PubMed
Google Scholar
Visser E, Milne D, Collacott I, McLernon D, Counsell C, Vickers M. The epidemiology of infectious mononucleosis in Northern Scotland : a decreasing incidence and winter peak. BMC Infect Dis. 2014;14:151.
Article
PubMed Central
PubMed
Google Scholar
Pakpoor J, Disanto G, Gerber JE, Dobson R, Meier UC, Giovannoni G, et al. The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis. Mult Scler. 2013;19:162–6.
Article
PubMed
Google Scholar
Toussirot E, Roudier J. Epstein-Barr virus in autoimmune diseases. Best Pract Res Clin Rheumatol. 2008;22:883–96.
Article
CAS
PubMed
Google Scholar