- Research article
- Open Access
Exercise therapy after ultrasound-guided corticosteroid injections in patients with subacromial pain syndrome: a randomized controlled trial
Arthritis Research & Therapyvolume 18, Article number: 129 (2016)
Subacromial pain syndrome (SAPS) accounts for around 50 % of all cases of shoulder pain. The most commonly used treatments are glucocorticosteroid (steroid) injections and exercise therapy; however, despite treatment SAPS patients often experience relapse of their symptoms. Therefore the clinical effect of combining steroid and exercise therapy is highly relevant to clarify. The aim of this randomized controlled trial was to investigate if exercise therapy added to steroid injection in patients with SAPS will improve the effect of the injection therapy on shoulder pain.
In this two-arm randomized trial running over 26 weeks, patients with unilateral shoulder pain (> 4 weeks) and thickened subacromial bursa (> 2 mm on US) were included. At baseline all participants received two steroid injections into the painful shoulder with an interval of one week. Subsequently they were randomized (1:1) to either 10 weeks exercise of the involved shoulder (intervention group) or exercise of the uninvolved shoulder (control group). The patients were re-examined after the exercise program (at week 13) and again at week 26. The primary outcome assessed after 26 weeks was change in shoulder pain analyzed using the intention-to-treat principle (non-responder imputation).
Ninety-nine SAPS patients (58 female) participated (49 intervention/50 control). At both follow up visits (week 13 and 26) no statistically significant between-group differences in pain changes on a visual analog scale (mm) were seen (13 weeks: pain at rest 1.7 (95 % CI –3.6 to 7.0; P = 0.53); pain in activity 2.2 (95 % CI –6.5 to 10.9; P = 0.61), 26 weeks: rest 5.6 (95 % CI –0.9 to 12.1; P = 0.09); activity 2.2 (95 % CI –6.8 to 11.2; P = 0.62). The reduction in pain was most evident in the control group at all four pain measurements. The only difference between groups was seen by US examination at week 13, where fewer participants with impingement were observed in the intervention group compared with the controls (9 vs. 19 participants; P = 0.03).
Exercise therapy in the painful shoulder in SAPS patients did not improve the effectiveness of steroid injections for shoulder pain in patients with unilateral SAPS and enlarged subacromial bursa on US examination.
ClinicalTrials.gov (NCT01506804). Registration date 5 May 2011.
Shoulder pain is common and accounts for around 12 % of the contacts in primary care [1, 2] with subacromial pain syndrome (SAPS) accounting for approximately 50 % of cases of shoulder pain [3, 4]. SAPS is suggested to be a more comprehensive diagnosis than subacromial impingement to describe unspecific shoulder pain. The SAPS definition can be used as an umbrella diagnosis for all conditions affecting the structures of the subacromial space including enlarged subacromial bursa, rotator cuff and biceps tendon ruptures, and other pathological changes in the tendons [3, 5, 6].
The most commonly used treatments for SAPS are glucocorticosteroid (steroid) injection and exercise therapy. SAPS is often recurrent, so patients often receive an unstructured mix of both treatments [3, 7–10]. Effectiveness of each treatment has been demonstrated in the short term on pain and function. The choice of treatment is ambiguous and there is no standardized treatment algorithm, and the long-term effects of a stringent protocol investigating steroid injection and exercise therapy in combination have not been investigated [3, 7–10].
Inflammation and pain may impair muscle function . Experimental studies have shown that pain alters muscle recruitment strategies and strength [12–14]. Accordingly, it is plausible that pharmacological suppression of inflammation and pain prior to exercise may enhance the effect of the exercise. Also, exercise may suppress the inflammation  and may per se have additional effects on the pharmacological treatment of the inflammation . The aim of the current study was to test whether the effect of steroid injections on SAPS may be improved by adding exercise therapy.
We conducted an assessor-blinded, two-arm, parallel-group, randomized controlled trial running over 26 weeks; primary outcome was assessed after 26 weeks (primary end point). A methodological protocol was developed and registered with ClinicalTrials.gov before the trial began (NCT01506804) 05/05-2011. The protocol was also approved by the Regional Health Research Ethics Committee (H-4-2010-022). The trial was conducted in accordance with the Helsinki Declaration and this paper follows the CONSORT reporting guidelines . All participants signed an informed consent form before participating in the study.
Setting and eligibility criteria
Participants were recruited from a rheumatology outpatient clinic at a Hospital in Denmark and by advertising on a specific site on the Internet for participants for clinical trials, between May 2009 and April 2011.
Inclusion criteria were age 18 to 70 years and unilateral shoulder pain provoked by active shoulder abduction and lasting at least 4 weeks. In addition, an enlarged subacromial bursa (≥ 2 mm) as assessed by ultrasound imaging (US) in the symptomatic shoulder was required.
Exclusion criteria included complete or partial ruptures of the biceps or rotator cuff tendons assessed by US , symptoms originating from the cervical spine, other conditions explaining the shoulder pain, capsular pattern restriction, contraindications to steroid or lidocaine or exercise therapy, steroid injection of either shoulder within the previous 3 months, and any previous shoulder surgery.
Potentially eligible participants having received oral and written information about the study were invited to a clinical examination by a rheumatologist and an US examination of the shoulder. Upon inclusion, and subsequent to baseline assessments, the participants received two US-guided injections of steroid in the thickened bursa in the painful shoulder, given with an interval of 1 week. Two injections were given to increase the chances of a clinical effect. After the second injection, the participants were randomized. The intervention group received a training program for the painful shoulder. The control group received the same program for the asymptomatic shoulder. Both groups commenced the training program 1 week after receiving the second injection. The exercise program lasted for 10 weeks.
Randomization, treatment allocation and blinding
The participants were randomized 1:1 in blocks of 4–6 using an envelope-based lottery. The individual allocations were held in sealed opaque envelopes. The leader of the project (KE), who was blinded to all clinical data, made the allocation. Due to the type of treatment in both the intervention and control group neither the participant nor the person performing the intervention were blinded. The persons performing the clinical tests and training sessions in both intervention and control group were blinded to the self-reported shoulder function. The person performing all the statistical analysis was blinded to group allocation.
The two injections given (separated by 1 week) each contained 1 mL methylprednisolone (40 mg Depo-Medrol®, Pfizer) and 2 mL lidocaine (5 %). All injections were given US-guided, as it has been shown that the effect on pain and function is superior to blind injections [19–21]. An experienced radiologist specializing in US (STP) gave the injections. The US examinations were carried out using a Logic E9 with a 15 MHz linear array transducer (General Electric Medical System, Milwaukee, WI, USA).
Patients sat in an upright position. The arm was positioned behind the lower back, with the elbow flexed. The US probe was placed on the lateral contour of the shoulder parallel to the underlying supraspinatus tendon. The injection was performed with a lateral approach and real-time US evidence of the bolus being correctly distributed in the enlarged bursa.
The exercise intervention followed the descriptors by Toigo & Boutellier . The exercise program consisted of three sessions per week for 10 weeks, with one session per week being supervised by a physiotherapist; the other was home based. Additional file 1 describes the exercise program in detail. If the exercises caused shoulder pain rated as > 50 mm on a 10–mm visual analog scale (VAS), which did not subside immediately, loading was reduced. A sensation of post exercise muscle fatigue and delayed onset muscle soreness was regarded as acceptable. The same exercise program was used in both groups, but on different shoulders (involved/non-involved as per the allocation).
During the first 2 weeks of exercise, (phase 1), the emphasis was on scapula muscle control and strength. The following 8 weeks (phase 2) aimed at progressive strengthening of the muscles of the rotator cuff. The program rationale was to target muscle function deficits of the scapula prior to targeting muscle function deficits of the rotator cuff muscles [4, 23]. An exercise diary was used in both groups.
Outcome measurements and assessment
Outcomes were measured at baseline (before the first injection), at the week-13 visit (after the exercise program), and at a 26-week follow-up visit (12 weeks after cessation of the exercise program). As the purpose of this study was to assess the effect of stringent combined pharmacological and exercise therapy the co-primary outcomes were changes from baseline in current shoulder pain during active shoulder abduction and at rest at the 26-week follow up (primary end point). These pain measures were assessed on 0–100 mm VAS with anchors being 0 = no pain and 100 = worst imaginable pain. The secondary outcomes were the same pain ratings at week 13; clinical impingement signs (Hawkins-Kennedy test), US impingement test, subacromial bursa size on US (size; mm), self-reported shoulder function (Shoulder Disability Questionnaire (SDQ)), and isometric muscle strength.
In the Hawkins-Kennedy sign the shoulder pain is reproduced by shoulder flexion followed by a forced internal rotation . The test is positive if the shoulder pain is reproduced. On US-based impingement the acromion and the humeral head were simultaneously visualized by US during passive abduction of the shoulder joint. Impingement was indicated if the bursa and/or tendons were impinged at the edge of the acromial bone. Subacromial bursa enlargement was assessed from US examinations in two positions: (1) with the patients sitting in an upright position with the arm positioned behind the back and (2) in the same position but with the hand on the waist. In both positions, the transducer was moved until it was over the area where the thickness of the bursa was most pronounced. The maximal bursa size was obtained in both positions. We defined a bursa thickness > 2 mm as enlarged .
Isometric muscle strength
IMS was assessed unilaterally (painful shoulder) using a handheld dynamometer (Commander Power track II, JTEC Medical, USA). This method has been shown to be reliable for assessment of muscle strength in the shoulder and hip [26, 27]. IMS was measured in internal rotation, external rotation, and abduction, with each contraction lasting approximately 6 seconds. The abduction strength was tested in 45° shoulder abduction. IMS in internal and external rotation was assessed with the shoulder in the neutral position and the elbow flexed at 90°. All measurements were repeated four times with 10-second intervals and the maximum value was used for analysis. Standardized instructions and verbal encouragement were given .
Self-reported shoulder function
Self-reported functional status of the shoulder was assessed by the SDQ. The questionnaire consists of 16 items assessing pain during the previous 24 h in the shoulder during activities of daily living [29, 30]. Three answers are possible in each item: “yes”, “no” and “not applicable”. The shoulder function is measured as a score between 0 and 100 % expressing the proportion of “yes” scores in relation to the total number of answers. The “not applicable” items are not included in the analysis . A Danish version of the SDQ was not available, but the English version is validated . Two people with good English skills translated the test independently. The two translated versions were compared by the translators and the study manager. Any discrepancies in translations were discussed until consensus was reached.
Sample size and power considerations
This study was powered as a superiority trial for a comparison between the participants allocated to exercise of the painful shoulder (intervention) and those allocated to exercise of the non-painful shoulder (control). Assuming that the intervention produced a reduction in one of the co-primary outcomes (pain during active shoulder abduction and pain at rest) that was 10 mm larger than the control with a standard deviation of 20 mm and a conjectured correlation of 0.7 between the covariate (baseline pain) and the response (change in pain), we calculated that we would need 42 participants per group to test a two-tailed hypothesis with 80 % power and a 2.5 % significance level (P < 0.025), using the usual F test of the group effect in the general linear univariate model with fixed class effects (group; two levels (intervention vs. control)) with an additional fixed covariate (baseline pain). To account for attrition we decided to include 100 patients in total, yielding a power of 88.8 %. Although we also investigated effects on other outcomes, we did not power the trial for this because we had no a priori assumptions about effect sizes in our secondary outcomes and thus a larger trial may be needed to reliably detect these.
All data analyses were carried out according to a pre-established analysis plan. Analyses were done applying SAS (v. 9.2; SAS Institute Inc., Cary, NC, USA). All descriptive statistics and tests are reported in accordance with the recommendations of the Enhancing the Quality and Transparency Of health Research (EQUATOR) network, as per the Consolidated Standards of Reporting Trials (CONSORT) statement . In order to evaluate the empirical distributions of continuous outcomes, visual inspection was used to suggest whether the assumption of normality was reasonable.
All patients randomized were assessed for efficacy and safety (i.e., intention-to-treat (ITT) population). At 13 weeks (the end of intervention) and after 26 weeks, the exercise and control groups were compared using analysis of covariance (ANCOVA) to analyze mean changes from baseline in the outcomes. The model included the change as the dependent variable, with treatment group as a main effect and the baseline score as an additional covariate.
The proportion of patients, who were impingement-positive on US and/or on clinical assessment at the 13-week and 26-week follow up, were analyzed using the chi-square test to evaluate the differences between proportions between the exercise and control group and the group differences are presented as risk differences with 95 % confidence interval.
The baseline observation carried forward (BOCF) approach was used for patients who did not complete the study, as this method seems conservative in self-help management programs; i.e., using a non-responder imputation. As this trial was designed as a pragmatic trial, baseline data were only imputed when the patient did not attend follow-up visits, and was not based on adherence rate or compliance considerations. Unless stated otherwise, results are expressed as the mean difference between the groups and 95 % confidence intervals (95 % CI) with the associated P values, based on the ANCOVA model.
The flow of patients through the trial can be seen in Fig. 1: 99 patients were included in the study. Participant number 100 volunteered but did not attend the baseline assessment and was not randomized. Because the treatment allocation was done in blocks we decided to commence the last block of participants even though the last participant was missing. Characteristics of the study sample are presented in Table 1. In the intervention group, 17 participants were lost to follow up; in the control group 18 patients were lost to follow-up (Fig. 1).
Compliance with exercise
Exercise diaries were only collected from the participants who completed the study (n = 65) and the compliance rate was calculated for these participants. In the intervention group 27 of the 33 completers filled in an exercise diary with an average number of exercise sessions of 29 out of 30 (97 %). In the control group, 31 of 32 participants filled in a diary and the number of exercise sessions was 26 out of 30 (87 %).
We found no statistically significant differences between groups in the co-primary pain outcomes at week 26 (Fig. 2). The group difference in change from baseline in pain during active abduction was 2.2 mm (95 % CI –6.8 to 11.2; P = 0.62). The group difference in change from baseline in pain at rest was 5.6 mm (95 % CI –0.9 to 12.1; P = 0.088), potentially in favor of the control group.
At the 13-week follow up the group difference in change from baseline in pain at rest was 1.7 mm (95 % CI –3.6 to 6.0; P = 0.53) and the group difference in change from baseline in pain during shoulder abduction was 2.2 mm (95 % CI –6.5 to 10.9; P = 0.61), potentially in favor of the control group.
There were no statistically significant differences between the groups in thickness of the subacromial bursa as seen on US, self-reported shoulder function (SDQ), clinical impingement test or isometric muscle strength at the 13-week or 26-week follow up (Table 2). At the 13-week follow up, there was a statistically significant difference between groups in the proportion of participants with a positive US impingement test, as only 18 % had a positive test in the intervention group as compared 38 % with a positive test in the control group (risk difference 0.20 (95 % CI 0.02 to 0.37); P = 0.03) (Table 2).
We investigated the effects of unilateral exercise therapy after steroid injections in the subacromial bursa in patients with SAPS. The exercise intervention was compared to exercise of the asymptomatic shoulder. There was no difference between the groups in the primary outcomes of shoulder pain at rest and activity at the 26-week follow up, although a tendency towards less pain at rest in the control group was observed. A group difference in US impingement at week 13 in favor of the intervention group was observed; however, more participants in the control group (25 vs. 16) had US impingement at baseline. This indicates that the result should be interpreted with caution. The difference was not maintained at week 26. No group differences were observed in any of the other secondary outcomes.
The equal beneficial change in pain in rest and activity in both groups is in agreement with a previous study of patients with SAPS . In that study the exercise intervention was more intense, with exercise twice daily. These extensive exercises improved the shoulder function. This may indicate that any exercise program can improve shoulder pain, but intensive exercise programs are necessary in order to improve shoulder function. This is supported by a study by Bennell et al.  in which there was no difference between an exercise and a placebo group after 10 weeks of daily therapy. However, there was a statistically significant difference between groups 12 weeks after the end of the interventions. As no standardized intervention was offered in the follow-up period the results must be interpreted tentatively.
In contrast to other studies investigating the effect of exercise therapy we added no other physiotherapy techniques, such as manual therapy, to the training or control interventions, thus minimising the bias of a mixed intervention [33, 34].
In our study, we observed a minor increase in muscle strength in both groups, but no differences between groups. The intensity of our exercise program is comparable to the standard care offered to patients with SAPS in clinical practice [8, 9, 35–37]. Furthermore, our exercise intervention is in accordance with the newest clinical guideline for SAPS, in which US-guided steroid injections are also recommended as a part of the management of SAPS . There is no consensus on the number of steroid injections needed in patients with SAPS, thus our choice of two injections was pragmatic and based on our clinical experience. One might argue that despite a rather intensive treatment, the changes in all assessed parameters from baseline were minor in both groups. This may underline the fact that there is no highly effective treatment for patients with SAPS and enlarged bursa.
Another study comparing exercise therapy after steroid injection with exercise therapy alone  found no difference between the groups in pain and function. Even though that study investigated steroid injection as an add-on to exercise, as opposed to our study, the results of both studies indicate that a combination of the two treatment strategies does not improve the treatment outcome in SAPS. This suggests that the choice of injection, exercise, or their combination, must depend on an individual assessment including patient and physician preferences.
Patients with SAPS form a heterogeneous group and clinical tests used to verify specific diagnoses and guide treatment are not particularly reliable or valid [6, 38]. It has been highlighted that the uncertain clinical classification may affect the outcomes of clinical studies . In an attempt to overcome this problem, the participants in our study were included based on subacromial bursa enlargement identified on US. To our knowledge this is the first study using a standardized US examination to define the study population in SAPS. There is no consensus on the threshold to define pathological thickening of the subacromial bursa, but the majority of the literature applies a bursa thickness of < 2 mm as normal [25, 39, 40]. Albeit arbitrary, we used this threshold as an inclusion criterion and our study population can be considered as having SAPS with concomitant US-based pathological change. We also used US to rule out any tendon tear of the rotator cuff and biceps tendon. The use of US as the first choice imaging modality in patients with SAPS is in agreement with the newest guidelines .
Our cohort reflected the general population of persons with shoulder complaints as the mean age was around 50 years and the majority was women [1, 2]. As explained to the control group, the intervention on the contralateral shoulder in our study may indeed be suspected of inducing a cross-over effect. With respect to muscle strength, gains in the untrained extremity have been reported to account for about one third of the improved strength in the trained extremity . This cross-over might be a limitation of our study and in support of a cross-over effect, our results indicated that the control group increased their external shoulder rotation muscle strength in the untrained, painful arm. However, the absence of increased muscle strength in abduction and internal rotation in both groups to some extent contradicts this bias. Similarly, an effect of the control exercise on pain is certainly possible. A study has shown improvements in knee pain following isolated hip abductor strengthening exercises . This consideration also suggests that contralateral or general exercises can be used in cases where exercises of the involved shoulder cannot be accomplished. The reason for choosing training of the contralateral shoulder as control, despite the described effects of this training, was owed to the well-known positive effect of attention from a health professional. In order to avoid this bias, we decided that the persons in both groups should have exactly the same attention from a physiotherapist. Further, the additional value of exercise therapy might be less pronounced in the dominant arm, but this was not recorded and therefore cannot be explored.
It is a limitation of our study that the exercise compliance was only evaluated in the completer participants, and it is not unlikely that the participants lost to follow up had poor adherence to the programs. Nevertheless, the compliance was comparable between groups, which indicates that bias due to difference in exercise compliance was small in our study. Another limitation of the study is that the attrition rate was relatively high. The most common reason for drop-out was lack of time. The reported effect of the steroid injections among drop-out participants was comparable to the compliant subjects (n = 12 vs. n = 16; missing data, n = 6), indicating that the initial effect of the study participation was not the main reason for leaving the study.
In patients with SAPS and enlarged subacromial bursa, 10 weeks of unilateral exercise of the symptomatic shoulder, given as an add-on to two sequential steroid injections into the subacromial bursa, did not improve the primary outcome of shoulder pain, compared to exercise of the asymptomatic shoulder (control). Effects on functional ability, clinical impingement signs, or muscle strength when compared to exercise of the uninvolved shoulder were also comparable between groups. The results indicate a short-term benefit on US-assessed impingement test immediately after the exercise program; however, this effect was not maintained at the 26-week follow up.
analysis of covariance
baseline observation carried forward
Enhancing the Quality and Transparency Of health Research
isometric muscle strength
subacromial pain syndrome
Shoulder Disability Questionnaire
visual analog scale
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The study was supported by the Oak Foundation, the Danish Physiotherapy Foundation, Aase and Ejnar Danielsens Foundation, Danish Rheumatism Association.
KE designed the study, performed all US examinations, and drafted the manuscript. RC performed the statistical analysis and helped to revise the manuscript. SR designed and carried out both the exercise intervention and the physical therapy examination. CB carried out both the exercise intervention and the physical therapy examination and wrote the appendix. STP performed some of the US examinations and carried out all the US-guided injections and helped to revise the manuscript. TB helped to design the exercise intervention and the physical therapy examination and revised the manuscript. BDS helped to revise both the study protocol and the manuscript. HB helped to revise both the study protocol and the manuscript and carried out all the clinical examinations of subjects before inclusion in the study. MH participated in the design of the study and the draft of the manuscript and revised the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
The exercise intervention. The file describes the exercise intervention in detail. (DOC 35 kb)