Open Access

Erratum to: Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

  • Tatsuya Tamura1Email author,
  • Yoshinobu Higuchi1,
  • Hidetomo Kitamura1,
  • Naoaki Murao1,
  • Ryoichi Saitoh1,
  • Tadashi Morikawa2 and
  • Haruhiko Sato1
Arthritis Research & Therapy201618:121

https://doi.org/10.1186/s13075-016-1029-7

Received: 18 May 2016

Accepted: 19 May 2016

Published: 31 May 2016

The original article was published in Arthritis Research & Therapy 2016 18:79

After publication of this article [1] it was noticed that Figs. 2 and 4 (seen below) contained incorrect characters. The corrected figures can be seen below and the original article has also been updated to reflect this.
Fig. 2

Effect of DK226 on proliferation of human synovial fibroblast-like cells (HFLS) and of human synovial sarcoma cell line SW982. a Inhibition of tumor necrosis alpha (TNF-α)-induced proliferation of HFLS by hyaluronic acid (HA) or DK226 at increasing, equivalent HA concentrations. b Effect of exogenously added HA on the anti-proliferative effect of DK226 in HFLS. c Inhibition of proliferation of SW982 by methotrexate (MTX) or DK226 at increasing, equivalent MTX concentrations. d Effect of exogenously added anti-CD44 antibody (BU75) and anti-IgG2a (control antibody) on the anti-proliferative effect of DK226 in SW982. Values are means and standard error of the mean (SEM) (n = 4)

Fig. 4

Effect of DK226 on collagen-induced arthritis (CIA) in rat knee joints. a Effect of intra-articular hyaluronic acid (HA) (0.5 mg) or DK226 (0.5 mg HA-equiv, 26 nmol MTX-equiv) on knee swelling of the right knee (treated) shown on the left panel, and the effect in the left knee (untreated) shown on the right panel. b Histopathology of the right knee joints after treatment with intra-articular HA or DK226. Sections were stained with safranin O/fast green. T tibia, Mmeniscus, F femur. Scale bars indicate 100 μm. c and d Histologic analysis of synovial tissue (c) and lateral condyle of the femur (d). Values are means and standard error of the mean (SEM) (n = 3–10 in a, c and d: n = 3, Normal + vehicle; n = 9–10, CIA + vehicle, HA or DKA226). # P < 0.05: significantly different from Normal + vehicle group (Wilcoxon rank sum test). *P < 0.05: significantly different from HA group (Wilcoxon rank sum test)

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Research Division, Chugai Pharmaceutical Co., Ltd.
(2)
New Business Planning Department, Denka Co., Ltd.

Reference

  1. Tatsuya T, Yoshinobu H, Hidetomo K, Naoaki M, Ryoichi S, Tadashi M, Haruhiko S. Novel hyaluronic acid-methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models. Arthritis Res Ther. 2016;18:79. doi:https://doi.org/10.1186/s13075-016-0971-8.View ArticleGoogle Scholar

Copyright

© The Author(s). 2016

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