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Table 3 Genetic pathways associated with the SLE phenotypes in the discovery stage

From: Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

Pathway

Phenotype

#Genes

SNPs

P D

FDR D

P V

FDR V

P C

RIG-I/MDA5 negative regulation signaling

Antinuclear antibodies

31

464

2.00e-5

0.016

0.234

0.234

-

VEGFa

Oral ulcers

29

883

5.58e-5

0.044

0.013

0.026

2.08e-5

  1. Two genetic pathways were significantly associated with systemic lupus erythematosus (SLE) phenotypes in the discovery stage
  2. Abbreviations: SNP single-nucleotide polymorphism, P D P value discovery cohort, FDR D false discovery rate discovery cohort, P V P value validation cohort, FDR V false discovery rate validation cohort, P C P value combined
  3. aThe association between the vascular endothelial growth factor (VEGF) pathway and oral ulcers was significantly replicated in the validation cohort
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Arthritis Research & Therapy

ISSN: 1478-6362

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