Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006;15(5):308–18.
Article
CAS
PubMed
Google Scholar
Lisnevskaia L, Murphy G, Isenberg D. Systemic lupus erythematosus. Lancet. 2014;384(9957):1878–88. doi:10.1016/S0140-6736(14)60128-8. Epub 62014 May 60131.
Article
PubMed
Google Scholar
Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25(11):1271–7.
Article
CAS
PubMed
Google Scholar
Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, Nath SK, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40(2):204–10. doi:10.1038/ng.81.Epub2008Jan1020.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bentham J, Morris DL, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martin J, Fairfax BP, Knight JC, Chen L, et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet. 2015;47(12):1457–64. doi:10.1038/ng.3434.Epub2015Oct1426.
Article
CAS
PubMed
PubMed Central
Google Scholar
Olson JM, Song Y, Dudek DM, Moser KL, Kelly JA, Bruner GR, Downing KJ, Berry CK, James JA, Harley JB. A genome screen of systemic lupus erythematosus using affected-relative-pair linkage analysis with covariates demonstrates genetic heterogeneity. Genes Immun. 2002;3 Suppl 1:S5–S12.
Article
CAS
PubMed
Google Scholar
Ceccarelli F, Perricone C, Borgiani P, Ciccacci C, Rufini S, Cipriano E, Alessandri C, Spinelli FR, Sili Scavalli A, Novelli G, et al. Genetic factors in systemic lupus erythematosus: contribution to disease phenotype. J Immunol Res. 2015;2015:745647. doi:10.1155/2015/745647.Epub742015Dec745621.
Article
PubMed
PubMed Central
Google Scholar
De Azevêdo SJ, Addobbati C, Sandrin-Garcia P, Crovella S. Systemic lupus erythematosus: old and new susceptibility genes versus clinical manifestations. Curr Genomics. 2014;15(1):52–65. doi:10.2174/138920291501140306113715.
Article
Google Scholar
Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Gilkeson GS, Ziegler JT, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis. 2011;70(10):1752–7. doi:10.1136/ard.2011.154104.Epub152011Jun154130.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, et al. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet. 2008;4(5):e1000084. doi:10.1371/journal.pgen.1000084.
Article
PubMed
PubMed Central
Google Scholar
Robinson MR, Wray NR, Visscher PM. Explaining additional genetic variation in complex traits. Trends Genet. 2014;30(4):124–32. doi:10.1016/j.tig.2014.02.003.Epub2014Mar1011.
Article
CAS
PubMed
PubMed Central
Google Scholar
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, et al. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747–53. doi:10.1038/nature08494.
Article
CAS
PubMed
PubMed Central
Google Scholar
Du Y, Xie J, Chang W, Han Y, Cao G. Genome-wide association studies: inherent limitations and future challenges. Front Med. 2012;6(4):444–50. doi:10.1007/s11684-012-0225-3.Epub12012Nov11683.
Article
PubMed
Google Scholar
Johnson RC, Nelson GW, Troyer JL, Lautenberger JA, Kessing BD, Winkler CA, O'Brien SJ. Accounting for multiple comparisons in a genome-wide association study (GWAS). BMC Genomics. 2010;11:724. doi:10.1186/1471-2164-1111-1724.
Article
PubMed
PubMed Central
Google Scholar
Zhang K, Cui S, Chang S, Zhang L, Wang J. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res. 2010;38(Web Server issue):W90–95. doi:10.1093/nar/gkq1324.Epub2010Apr1030.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gui H, Li M, Sham PC, Cherny SS. Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's disease dataset. BMC Res Notes. 2011;4:386. doi:10.1186/1756-0500-1184-1386.
Article
PubMed
PubMed Central
Google Scholar
Ramanan VK, Shen L, Moore JH, Saykin AJ. Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet. 2012;28(7):323–32. doi:10.1016/j.tig.2012.03.004.Epub2012Apr1013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, Lin X. Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet. 2010;86(6):929–42. doi:10.1016/j.ajhg.2010.05.002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen D, Enroth S, Ivansson E, Gyllensten U. Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection. Hum Mol Genet. 2014;23(22):6047–60. doi:10.1093/hmg/ddu304.Epub2014Jun6016.
Article
CAS
PubMed
Google Scholar
Aterido A, Julia A, Ferrandiz C, Puig L, Fonseca E, Fernandez-Lopez E, Dauden E, Sanchez-Carazo JL, Lopez-Estebaranz JL, Moreno-Ramirez D, et al. Genome-wide pathway analysis identifies genetic pathways associated with psoriasis. J Invest Dermatol. 2016;136(3):593–602. doi:10.1016/j.jid.2015.11.026.Epub2015Dec1029.
Article
CAS
PubMed
Google Scholar
Julia A, Tortosa R, Hernanz JM, Canete JD, Fonseca E, Ferrandiz C, Unamuno P, Puig L, Fernandez-Sueiro JL, Sanmarti R, et al. Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes. Hum Mol Genet. 2012;21(20):4549–57. Epub 2012 Jul 4519.
Article
CAS
PubMed
Google Scholar
Yu C, Gershwin ME, Chang C. Diagnostic criteria for systemic lupus erythematosus: a critical review. J Autoimmun. 2014;48-49:10–3. doi:10.1016/j.jaut.2014.1001.1004. Epub 2014 Jan 1021.
Article
CAS
PubMed
Google Scholar
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559–75. Epub 2007 Jul 2025.
Article
CAS
PubMed
PubMed Central
Google Scholar
Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–9. Epub 2006 Jul 2023.
Article
CAS
PubMed
Google Scholar
Marchini J, Howie B, Myers S, McVean G, Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet. 2007;39(7):906–13.
Article
CAS
PubMed
Google Scholar
Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190–1. doi:10.1093/bioinformatics/btq340. Epub 2010 Jul 2198.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang K, Li M, Hakonarson H. Analysing biological pathways in genome-wide association studies. Nat Rev Genet. 2010;11(12):843–54. doi:10.1038/nrg2884.
Article
CAS
PubMed
Google Scholar
de Leeuw CA, Neale BM, Heskes T, Posthuma D. The statistical properties of gene-set analysis. Nat Rev Genet. 2016;17(6):353–64. doi:10.1038/nrg.2016.29.
Article
PubMed
Google Scholar
Liberzon A, Subramanian A, Pinchback R, Thorvaldsdottir H, Tamayo P, Mesirov JP. Molecular signatures database (MSigDB) 3.0. Bioinformatics. 2011;27:1739–40. doi:10.1093/bioinformatics/btr260. Epub 2011 May 1735.
Article
CAS
PubMed
PubMed Central
Google Scholar
Edwards YJ, Beecham GW, Scott WK, Khuri S, Bademci G, Tekin D, Martin ER, Jiang Z, Mash DC, ffrench-Mullen J, et al. Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach. PLoS One. 2011;6(2):e16917. doi:10.1371/journal.pone.0016917.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lesiak A, Narbutt J, Kobos J, Kordek R, Sysa-Jedrzejowska A, Norval M, Wozniacka A. Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Clin Exp Dermatol. 2009;34(5):570–5. doi:10.1111/j.1365-2230.2008.03006.x. Epub 02008 Dec 03010.
Article
CAS
PubMed
Google Scholar
Chang AY, Werth VP. Treatment of cutaneous lupus. Curr Rheumatol Rep. 2011;13(4):300–7. doi:10.1007/s11926-011-0180-z.
Article
CAS
PubMed
PubMed Central
Google Scholar
Khandpur S, Sharma VK, Sumanth K. Topical immunomodulators in dermatology. J Postgrad Med. 2004;50(2):131–9.
CAS
PubMed
Google Scholar
Ihaka R, Gentleman G. R: A language for data analysis and graphics. J Comput Graph Stat. 1996;5(5):299–314.
Google Scholar
Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 2006;312(5):549–60. Epub 2005 Dec 2005.
Article
CAS
PubMed
Google Scholar
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25(4):581–611.
Article
CAS
PubMed
Google Scholar
Sakly N, Mirshahi P, Ducros E, Soria J, Ghedira I, Mirshahi M. Angiogenic activity in sera of patients with systemic lupus erythematosus. Lupus. 2009;18(8):705–12. doi:10.1177/0961203309103087.
Article
CAS
PubMed
Google Scholar
Walchner M, Meurer M, Plewig G, Messer G. Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus. Int J Dermatol. 2000;39(5):383–8.
Article
CAS
PubMed
Google Scholar
Cuadrado MJ, Karim Y, Sanna G, Smith E, Khamashta MA, Hughes GR. Thalidomide for the treatment of resistant cutaneous lupus: efficacy and safety of different therapeutic regimens. Am J Med. 2005;118(3):246–50.
Article
CAS
PubMed
Google Scholar
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M. Vascular endothelial growth factor in systemic lupus erythematosus: relationship to disease activity, systemic organ manifestation, and nailfold capillaroscopic abnormalities. Arch Immunol Ther Exp (Warsz). 2007;55:179–85. Epub 2007 Jun 2008.
Article
CAS
Google Scholar
Moneib HA, Salem SA, Aly DG, Khedr HT, Wafaey HA, Hassan HE. Assessment of serum vascular endothelial growth factor and nail fold capillaroscopy changes in systemic lupus erythematosus with and without cutaneous manifestations. J Dermatol. 2012;39(1):52. doi:10.1111/j.1346-8138.2011.01322.x. Epub 02011 Sep 01328.
Article
CAS
PubMed
Google Scholar
Mustafa MB, Porter SR, Smoller BR, Sitaru C. Oral mucosal manifestations of autoimmune skin diseases. Autoimmun Rev. 2015;14(10):930–51. doi:10.1016/j.autrev.2015.06.005.Epub2015Jun1024.
Article
PubMed
Google Scholar
Khatibi M, Shakoorpour AH, Jahromi ZM, Ahmadzadeh A. The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus. Lupus. 2012;21(12):1312–5. Epub 2012 Jul 1325.
Article
CAS
PubMed
Google Scholar
Munoz-Corcuera M, Esparza-Gomez G, Gonzalez-Moles MA, Bascones-Martinez A. Oral ulcers: clinical aspects. A tool for dermatologists. Part II. Chronic ulcers. Clin Exp Dermatol. 2009;34:456–61. doi:10.1111/j.1365-2230.2009.03219.x. Epub 02009 Apr 03214.
Article
CAS
PubMed
Google Scholar
Arbiser JL, Johnson D, Cohen C, Brown LF. High-level expression of vascular endothelial growth factor and its receptors in an aphthous ulcer. J Cutan Med Surg. 2003;7(3):225–8.
Article
PubMed
Google Scholar
Jacobson JM, Greenspan JS, Spritzler J, Ketter N, Fahey JL, Jackson JB, Fox L, Chernoff M, Wu AW, MacPhail LA, et al. Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. N Engl J Med. 1997;336(21):1487–93.
Article
CAS
PubMed
Google Scholar
Grinspan D. Significant response of oral aphthosis to thalidomide treatment. J Am Acad Dermatol. 1985;12(1 Pt 1):85–90.
Article
CAS
PubMed
Google Scholar
Urman JD, Lowenstein MB, Abeles M, Weinstein A. Oral mucosal ulceration in systemic lupus erythematosus. Arthritis Rheum. 1978;21(1):58–61.
Article
CAS
PubMed
Google Scholar
Parodi A, Massone C, Cacciapuoti M, Aragone MG, Bondavalli P, Cattarini G, Rebora A. Measuring the activity of the disease in patients with cutaneous lupus erythematosus. Br J Dermatol. 2000;142(3):457–60.
Article
CAS
PubMed
Google Scholar
Taylor J, Glenny AM, Walsh T, Brocklehurst P, Riley P, Gorodkin R, Pemberton MN. Interventions for the management of oral ulcers in Behcet's disease. Cochrane Database Syst Rev. 2014;9:CD011018. doi:10.1002/14651858.CD14011018.pub14651852.
Google Scholar
Yalcin B, Arda N, Tezel GG, Erman M, Alli N. Expressions of vascular endothelial growth factor and CD34 in oral aphthous lesions of Behcet's disease. Anal Quant Cytol Histol. 2006;28(6):303–6.
PubMed
Google Scholar
Brozovic S, Vucicevic-Boras V, Mravak-Stipetic M, Jukic S, Kleinheinz J, Lukac J. Salivary levels of vascular endothelial growth factor (VEGF) in recurrent aphthous ulceration. J Oral Pathol Med. 2002;31(2):106–8.
Article
CAS
PubMed
Google Scholar
Kim YS, Park SW, Kim MH, Jang EJ, Park JS, Park SJ, Baik HW, Chung G, Hahm KB. Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers. J Gastroenterol Hepatol. 2008;23 Suppl 2:S131–9. doi:10.1111/j.1440-1746.2008.05404.x.
Article
CAS
PubMed
Google Scholar
Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, et al. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013;8(8):e69404. doi:10.1371/journal.pone.0069404. eCollection 0062013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Khatri P, Sirota M, Butte AJ. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol. 2012;8(2):e1002375. doi:10.1371/journal.pcbi.1002375. Epub 1002012 Feb 1002323.
Article
CAS
PubMed
PubMed Central
Google Scholar
ENCODE:Project:Consortium. The ENCODE (ENCyclopedia Of DNA Elements) Project. Science. 2004;306(5696):636–40.
Article
Google Scholar