Fig. 5

Expression of vascular adhesion protein-1 (VAP-1) in synovial tissue samples of mouse tibiotarsal joints. Representative VAP-1 immunohistochemical staining shows moderate staining of blood vessels at 2 weeks postinfection (a), more prominent staining at 4 weeks postinfection (b), and weak staining at 7 weeks postinfection (c). In the samples from the uninfected mice, only occasional VAP-1-positive blood vessels were observed (d). Immediately after the ceftriaxone treatment, expression of VAP-1 did not decline, but stayed at a moderate level (e). Arrows indicate VAP-1-positive blood vessels. Scale bar = 50 μm