Fig. 2
From: Next-generation sequencing profiling of mitochondrial genomes in gout
Mitochondrial positively associated alleles in gout-associated transfer RNA (tRNA) genes. a Cloverleaf structure of canonical tRNA. Various tRNA regions (acceptor stem, D-stem, D-loop, anticodon stem, anticodon loop, variable region, T-stem, T-loop) are shown. Numbers represent the nucleotide positions according to the conventional tRNA numbering system. Locations of tRNA positively associated alleles and cloverleaf structure of MT-TA (b), MT-TC (c), MT-TH (d), MT-TQ (e), MT-TS2 (f), MT-TT (g), and MT-TW (h). Of all positively associated alleles in gout-associated tRNA genes, four alleles (m.5628 T > C, m.5783G > A, m.5814 T > C, and m.15894G > A) disrupting Watson-Crick base-pairing (A-U, G-C) were regarded as potentially pathogenic alleles. Tertiary interactions between nucleotides are indicated by dotted lines. Arrows indicate the position of the tRNA mutations. Red, potentially pathogenic alleles; green, nonpathogenic alleles