From: Next-generation sequencing profiling of mitochondrial genomes in gout
Gene | Group 1 | Group 2 | Group 3 | ||||
---|---|---|---|---|---|---|---|
Gout n (%) | Non-gout n (%) | P | Gout n (%) | P | Non-gout n (%) | P | |
MT-ATP6 | 40 (76.92) | 69 (66.35) | 0.175 | 10 (19.23) | 9.03 × 10−6 | 25 (24.04) | 1.14 × 10−4 |
MT-ATP8 | 4 (7.69) | 12 (11.54) | 0.455 | 2 (3.85) | 1.10 × 10−1 | 12 (11.54) | 8.86 × 10−3 |
MT-CO1 | 26 (50.00) | 48 (46.15) | 0.650 | 14 (26.92) | 5.56 × 10−8 | 39 (37.50) | 3.41 × 10−7 |
MT-CO2 | 14 (26.92) | 20 (19.23) | 0.273 | 12 (23.08) | 7.34 × 10−7 | 20 (19.23) | 7.07 × 10−4 |
MT-CO3 | 42 (80.77) | 78 (75.00) | 0.420 | 6 (11.54) | 1.12 × 10−3 | 17 (16.35) | 2.01 × 10− 3 |
MT-CYB | 52 (100.00) | 104 (100.00) | 1.000 | 10 (19.23) | 9.03 × 10−6 | 40 (38.46) | 2.15 × 10−7 |
MT-ND1 | 33 (63.46) | 57 (54.81) | 0.302 | 9 (17.31) | 3.09 × 10−5 | 19 (18.27) | 1.01 × 10−3 |
MT-ND2 | 37 (71.15) | 69 (66.35) | 0.544 | 8 (15.38) | 1.04 × 10−4 | 22 (21.15) | 3.46 × 10− 4 |
MT-ND3 | 46 (88.46) | 88 (84.62) | 0.515 | 2 (3.85) | 1.10 × 10−1 | 17 (16.35) | 2.01 × 10−3 |
MT-ND4 | 52 (100.00) | 104 (100.00) | 1.000 | 7 (13.46) | 3.44 × 10−2 | 30 (28.85) | 1.64 × 10−5 |
MT-ND4L | 11 (21.15) | 19 (18.27) | 0.667 | 0 (0.00) | 1.000 | 9 (8.65) | 2.98× 10−2 |
MT-ND5 | 46 (88.46) | 99 (95.19) | 0.182 | 15 (28.85) | 8.35 × 10−9 | 32 (30.77) | 7.24 × 10−6 |
MT-ND6 | 31 (59.62) | 57 (54.81) | 0.568 | 9 (17.31) | 3.09 × 10−5 | 18 (17.31) | 1.42 × 10−3 |
MT-RNR1 | 35 (67.31) | 74 (71.15) | 0.622 | 4 (7.69) | 1.14 × 10−2 | 20 (19.23) | 7.07 × 10−4 |
MT-RNR2 | 52 (100.00) | 104 (100.00) | 1.000 | 5 (9.62) | 3.60 × 10−3 | 25 (24.04) | 1.14 × 10−4 |
MT-TRNA a | 26 (50.00) | 54 (51.92) | 0.821 | 18 (34.62) | 1.78 × 10−10 | 28 (26.92) | 3.62 × 10−5 |