| |
Non-AS
|
AS
| |
|---|
|
(n = 309,110)
|
(n = 30,911)
|
P value
|
|---|
|
Age, years (mean ± SD)
|
42 ± 17
|
42 ± 17
|
1.00
|
|
Sex
| | |
1.00
|
|
Female
|
114,560 (37.1)
|
11,456 (37.1)
| |
|
Male
|
194,550 (62.9)
|
19,455 (62.9)
| |
|
CCI (mean ± SD)
|
0.22 ± 0.74
|
0.35 ± 0.89
|
< 0.01
|
|
CCI group
| | |
< 0.01
|
|
0
|
269,864 (87.3)
|
24,208 (78.3)
| |
|
≥ 1
|
39,246 (12.7)
|
6703 (21.7)
| |
|
Prior IMID
|
|
Acute anterior uveitis
|
604 (0.194)
|
1695 (5.483)
|
< 0.01
|
|
Psoriasis
|
1019 (0.330)
|
455 (1.472)
|
< 0.01
|
|
Inflammatory bowel disease
|
71 (0.023)
|
18 (0.058)
|
< 0.01
|
|
Crohn’s disease
|
41 (0.013)
|
7 (0.023)
|
0.19
|
|
Ulcerative colitis
|
38 (0.012)
|
13 (0.042)
|
< 0.01
|
|
Systemic lupus erythematosus
|
193 (0.062)
|
79 (0.256)
|
< 0.01
|
|
Sjögren’s syndrome
|
137 (0.044)
|
99 (0.320)
|
< 0.01
|
|
Rheumatoid arthritis
|
401 (0.13)
|
345 (1.116)
|
< 0.01
|
|
Systemic sclerosis
|
20 (0.006)
|
10 (0.032)
|
< 0.01
|
|
Dermatomyositis
|
12 (0.004)
|
7 (0.023)
|
< 0.01
|
|
Polymyositis
|
11 (0.004)
|
1 (0.003)
|
0.93
|
|
Thromboangiitis obliterans
|
1 (0.0003)
|
1 (0.003)
|
< 0.01
|
|
Behcet’s disease
|
18 (0.006)
|
24 (0.078)
|
< 0.01
|
|
Pemphigus
|
16 (0.005)
|
2 (0.006)
|
0.77
|
|
Sarcoidosis
|
13 (0.004)
|
6 (0.019)
|
< 0.01
|
|
Vitiligo
|
144 (0.047)
|
30 (0.097)
|
< 0.01
|
- Data are presented as number (%) unless specified otherwise
- Abbreviations: AS ankylosing spondylitis, SD standard deviation, CCI Charlson comorbidity index, IMID immune-mediated inflammatory disease
