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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

Fig. 6

Osteoinductive effects of BMP-2 and -4 on cultured chondrocytes and tenocytes. BMP-2 or 4 (20, 100 or 250 ng/mL) or Noggin (100 ng/mL) were added during 10 days to cultured chondrocytes (a, b) and tenocytes (c, d). Alkaline phosphatase gene expression (Alpl) and specific activity were compared to untreated control cells (a, c). Additional differentiation marker genes were analyzed in cultured cells treated at the highest dose (b, d): matrix metalloproteinase 13 (Mmp13), type II and X collagen (Col2a1, Col10a1), bone γ-carboxyglutamate protein 2 (Bglap2, coding osteocalcin), osteopontin (Opn), SRY-box transcription factor 9 (Sox9), and osterix (Osx)

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Arthritis Research & Therapy

ISSN: 1478-6362

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