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Table 4 Power calculation of the current analysis

From: Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study

Exposure

Variance explained by index SNPs

Sample size (% cases)

Power to detect OR

1.05/0.95

1.10/0.91

1.15/0.87

1.20/0.83

Age at menarche

0.074

58,284 (24.64%)

28%

78%

98%

100%

Age at natural menopause

0.057

23%

67%

95%

100%

Age at first birth

0.002

6%

7%

10%

14%