Fig. 4
From: Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression
Arthritis attenuated by TET3+/− in an RA mouse model. A Representative patterns of staining for 5mC, 5hmC, TET1/2/3 (brown) in the ankle synovial tissue. B Serial changes in the arthritis score. WT-K/BxN (n = 8), TET3+/−-K/BxN (n = 9). C (Left) Representative sections of synovial tissues stained with hematoxylin (HE) and eosin and Safranin O (S-O). (Right) histological scores of inflammation/hyperplasia, bone erosion, and cartilage damage. WT-K/BxN (n = 4), TET3+/−-K/BxN (n = 5). D Images of micro-computed tomography. Red arrows correspond to bone erosion. WT-K/BxN (n = 1), TET3+/−-K/BxN (n = 1). E Sections of mouse synovial tissues stained with tartrate-resistant acidic phosphatase. WT-K/BxN (n = 2), TET3+/−-K/BxN (n = 2). Scale bar, 300 μm (A), 100 μm (left D), 50 μm (middle D), 200 μm (right D). Data are mean ± standard error of the mean (B and C). Two-tailed P values by the t-test. *P < 0.05, **P < 0.01, vs. WT-K/BxN (B and C)