Table 1 Baseline characteristics of the initial cohort

Age (years), mean (SD)

51.10 (11.12)

54.37 (10.70)

50.98 (11.12)

58.94 (8.22)

49.88 (11.02)

   ≥ 60

24,425 (27.6%)

1271 (39.1%)

23,154 (27.2%)

6471 (54.2%)

17,954 (23.5%)

  50–59

26,253 (29.7%)

938 (28.8%)

25,315 (29.7%)

3902 (32.7%)

22,351 (29.3%)

  40–49

20,016 (22.7%)

648 (19.9%)

19,368 (22.8%)

1248 (10.4%)

18,768 (24.6%)

  30–39

17,653 (20.0%)

396 (12.2%)

17,257 (20.3%)

327 (2.7%)

17,326 (23.5%)

Female

60,157 (68.1%)

379 (11.7%)

59,778 (70.2%)

6585 (55.1%)

53,572 (70.1%)

BMI (kg/m²), mean (SD)

24.25 (3.83)

26.86 (4.02)

24.15 (3.79)

26.42 (4.02%)

23.91 (3.69%)

   > 35

1098 (1.2%)

127 (3.9%)

971 (1.1%)

385 (3.2%)

713 (0.9%)

  30–35

5508 (6.2%)

482 (14.8%)

5026 (5.9%)

1579 (13.2%)

3929 (5.1%)

  27–30

11,635 (13.2%)

765 (23.5%)

10,870 (12.8%)

2630 (22.0%)

9005 (11.8%)

  24–27

23,705 (26.8%)

1124 (34.6%)

22,581 (26.5%)

3931 (32.9%)

19,774 (25.9%)

  18.5–24

43,425 (49.2%)

745 (22.9%)

42,680 (50.2%)

3350 (28.1%)

40,075 (52.5%)

  < 18.5

2949 (3.3%)

10 (0.3%)

2939 (3.5%)

64 (0.5%)

2885 (3.8%)

Missing

27

0

27

9

18

Smoking

  Current smoker

7480 (8.5%)

584 (18.0%)

6896 (8.1%)

1087 (9.1%)

6393 (8.4%)

  Stopped smoking

8747 (9.9%)

874 (26.9%)

7873 (9.3%)

2005 (16.8%)

6742 (8.8%)

  Never or seldom

121 (0.1%)

14 (0.4%)

107 (0.1%)

23 (0.2%)

98 (0.1%)

  Missing

71,997 (81.5%)

1781 (54.7%)

70,216 (82.5%)

8833 (73.9%)

63,164 (82.7%)

Drinking

  Current drinking

5079 (5.7%)

463 (14.2%)

4616 (5.4%)

981 (8.2%)

4098 (5.4%)

  Stopped drinking

2399 (2.7%)

294 (9.0%)

2105 (2.5%)

652 (5.5%)

1747 (2.3%)

  Seldom or never

80,840 (91.5%)

2496 (76.7%)

78,344 (92.1%)

10,311 (86.3%)

70,529 (92.3%)

  Missing

22

0

22

3

19

  Creatinine (mg/dL), mean (SD)

0.71 (0.31)

0.99 (0.55)

0.70 (0.29)

0.82 (0.53)

0.70 (0.25)

  Urate (mg/dL), mean (SD)

5.35 (1.40)

7.27 (1.85)

5.27 (1.33)

5.95 (1.50)

5.25 (1.36)

  Triglyceride (mg/dL), mean (SD)

117.27 (97.29)

168.91 (145.63)

115.30 (94.40)

144.06 (113.23)

113.08 (93.87)

  Total cholesterol (mg/dL), mean (SD)

196.58 (36.23)

193.35 (36.88)

196.70 (36.20)

190.94 (36.57)

197.46 (36.10)

  HDL (mg/dL), mean (SD)

55.10 (13.60)

46.66 (11.06)

55.42 (13.59)

50.27 (12.24)

55.86 (13.65)

  LDL (mg/dL), mean (SD)

120.85 (31.91)

120.16 (32.84)

120.87 (31.88)

116.59 (32.04)

121.51 (31.84)