Fig. 1
From: Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage
The reactivity of monoclonal ACPAs and COL2 reactive antibodies in vitro. A Antibody binding to joint tissue from naïve neonatal joints and arthritic joints obtained at D90 after immunization (historic maximum arthritis score = 13). B Antibody response to native triple-helical COL2 by ELISA detection. C Antibody in vitro reactivity to skin tissue from naïve mice and inflamed skin of mice with psoriasis at D5 after immunization. D Antibody in vitro reactivity to naïve Wistar rat esophagus. PBS is a negative control. × 40, × 100, and × 400 are the magnification of captured pictures