Holmdahl R, Malmström V, Burkhardt H. Autoimmune priming, tissue attack and chronic inflammation - the three stages of rheumatoid arthritis. Eur J Immunol. 2014;44(6):1593–9.
Article
CAS
PubMed
Google Scholar
Aho K, Palosuo T, Raunio V, Puska P, Aromaa A, Salonen JT. When does rheumatoid disease start? Arthritis Rheum. 1985;28:485–9.
Article
CAS
PubMed
Google Scholar
Kurki P, Aho K, Palosuo T, Heliövaara M. Immunopathology of rheumatoid arthritis. Antikeratin antibodies precede the clinical disease. Arthritis Rheum. 1992;35(8):914–7.
Article
CAS
PubMed
Google Scholar
Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741–9.
Article
PubMed
Google Scholar
van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL, et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum. 2004;50(3):709–15.
Article
PubMed
Google Scholar
Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998;101(1):273–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol. 1999;162(1):585–94.
CAS
PubMed
Google Scholar
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–19.
Article
CAS
PubMed
Google Scholar
Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM. The B cell response to citrullinated antigens in the development of rheumatoid arthritis. Nat Rev Rheumatol. 2018;14(3):157–69.
Article
CAS
PubMed
Google Scholar
Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, et al. Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 2008;58(10):3009–19.
Article
CAS
PubMed
Google Scholar
Masson-Bessière C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T, et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol. 2001;166(6):4177–84.
Article
PubMed
Google Scholar
Burkhardt H, Sehnert B, Bockermann R, Engström A, Kalden JR, Holmdahl R. Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol. 2005;35(5):1643–52.
Article
CAS
PubMed
Google Scholar
Vossenaar ER, Després N, Lapointe E, van der Heijden A, Lora M, Senshu T, et al. Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther. 2004;6(2):R142–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, et al. Structural basis of cross-reactivity of anti-citrullinated protein antibodies. Arthritis Rheum. 2019;71(2):210–21.
Article
CAS
Google Scholar
Tarkowski A, Klareskog L, Carlsten H, Herberts P, Koopman WJ. Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum. 1989;32(9):1087–92.
Article
CAS
PubMed
Google Scholar
Haag S, Schneider N, Mason DE, Tuncel J, Andersson IE, Peters EC, et al. Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen. Arthritis Rheum. 2014;66(6):1440–9.
Article
CAS
Google Scholar
Ge C, Holmdahl R. The structure, specificity and function of anti-citrullinated protein antibodies. Nat Rev Rheumatol. 2019;15(8):503–8.
Article
CAS
PubMed
Google Scholar
Liang B, Ge C, Lönnblom E, Lin X, Feng H, Xiao L, et al. The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis. Rheumatology (Oxford). 2019;58(9):1623–33.
Article
CAS
PubMed
Google Scholar
Tuomi T, Heliovaara M, Palosuo T, Aho K. Smoking, lung function, and rheumatoid factors. Ann Rheum Dis. 1990;49(10):753–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Klareskog L, Alfredsson L, Rantapaa-Dahlqvist S, Berglin E, Stolt P, Padyukov L. What precedes development of rheumatoid arthritis? Ann Rheum Dis. 2004;63(Suppl 2):ii28–31.
PubMed
PubMed Central
Google Scholar
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, et al. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nat Rev Rheumatol. 2018;14(9):542–57.
Article
PubMed
PubMed Central
Google Scholar
Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, et al. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009;206(2):449–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, et al. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. 2017;2(13):e93688.
Article
PubMed
PubMed Central
Google Scholar
Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint- specific autoimmune disease. Nat Immunol. 2002;3(4):360–5.
Article
CAS
PubMed
Google Scholar
Jonsson R, Karlsson AL, Holmdahl R. Demonstration of immunoreactive sites on cartilage after in vivo administration of biotinylated anti-type II collagen antibodies. J Histochem Cytochem. 1989;37(2):265–8.
Article
CAS
PubMed
Google Scholar
Li Y, Tong D, Liang P, Lönnblom E, Viljanen J, Xu B, et al. Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis. Arthritis Res Ther. 2020;22(1):120.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pereira RS, Black CM, Duance VC, Jones VE, Jacoby RK, Welsh KI. Disappearing collagen antibodies in rheumatoid arthritis. Lancet. 1985;2(8453):501–2.
Article
CAS
PubMed
Google Scholar
Lindh I, Snir O, Lönnblom E, Uysal H, Andersson I, Nandakumar KS, et al. Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice. Arthritis Res Ther. 2014;16(4):R143.
Article
PubMed
PubMed Central
Google Scholar
Sacitharan PK. Ageing and osteoarthritis. Subcell Biochem. 2019;91:123–59.
Article
CAS
PubMed
Google Scholar
van Delft MAM, van Beest S. Presence of autoantibodies in erosive hand osteoarthritis and association with clinical presentation. J Rheumatol. 2019;46(1):101–5.
Article
PubMed
Google Scholar
Xie X, van Delft MAM, Shuweihdi F, Kingsbury SR, Trouw LA, Doody GM, et al. Auto-antibodies to post-translationally modified proteins in osteoarthritis. Osteoarthritis Cartilage. 2021;29(6):924–33.
Article
CAS
PubMed
Google Scholar
Burkhardt H, Koller T, Engström A, Nandakumar KS, Turnay J, Kraetsch HG, et al. Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse. Arthritis Rheum. 2002;46(9):2339–48.
Article
CAS
PubMed
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315–24.
Article
CAS
PubMed
Google Scholar
Altman RD. Criteria for the classification of osteoarthritis of the knee and hip. Scand J Rheumatol Suppl. 1987;65:31–9.
Article
CAS
PubMed
Google Scholar
Viljanen J, Lönnblom E, Ge C, Yang J, Cheng L, Aldi S, et al. Correction to synthesis of an array of triple-helical peptides from type II collagen for multiplex analysis of autoantibodies in rheumatoid arthritis. ACS Chem Biol. 2020;15(11):3072.
Article
CAS
PubMed
Google Scholar
Khmaladze I, Kelkka T, Guerard S, Wing K, Pizzolla A, Saxena A, et al. Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. Proc Natl Acad Sci U S A. 2014;111(35):E3669–78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mo JA, Holmdahl R. The B cell response to autologous type II collagen: biased V gene repertoire with V gene sharing and epitope shift. J Immunol. 1996;157(6):2440–8.
CAS
PubMed
Google Scholar
Rönnelid J, Hansson M, Mathsson-Alm L, Cornillet M, Reed E, Jakobsson PJ, et al. Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants. Ann Rheum Dis. 2018;77(2):203–11.
Article
PubMed
Google Scholar
Reed E, Hedström AK, Hansson M, Mathsson-Alm L, Brynedal B, Saevarsdottir S, et al. Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity. Arthritis Res Ther. 2020;22(1):170.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hensvold AH, Frisell T, Magnusson PK, Holmdahl R, Askling J, Catrina AI. How well do ACPA discriminate and predict RA in the general population: a study based on 12 590 population-representative Swedish twins. Ann Rheum Dis. 2017;76(1):119–25.
Article
PubMed
Google Scholar
Malhotra R, Wormald MR, Rudd PM, Fischer PB, Dwek RA, Sim RB. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein [see comments]. Nat Med. 1995;1(3):237–43.
Article
CAS
PubMed
Google Scholar
Matsumoto A, Shikata K, Takeuchi F, Kojima N, Mizuochi T. Autoantibody activity of IgG rheumatoid factor increases with decreasing levels of galactosylation and sialylation. J Biochem. 2000;128(4):621–8.
Article
CAS
PubMed
Google Scholar
Wouters F, Maurits MP, van Boheemen L, Verstappen M, Mankia K, Matthijssen XME, et al. Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis. Ann Rheum Dis. 2022;81(1):48–55.
Shaw T, Quan J, Totoritis MC. B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience. Ann Rheum Dis. 2003;62 Suppl 2(Suppl 2):ii55–9.
CAS
PubMed
Google Scholar
Stuart JM, Dixon FJ. Serum transfer of collagen induced arthritis in mice. J Exp Med. 1983;158:378–92.
Article
CAS
PubMed
Google Scholar
Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H. Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 1986;29:400–10.
Article
CAS
PubMed
Google Scholar
Bersellini Farinotti A, Wigerblad G. Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons. J Exp Med. 2019;216(8):1904–24.
Article
PubMed
PubMed Central
Google Scholar
Nandakumar KS, Svensson L, Holmdahl R. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003;163(5):1827–37.
Article
CAS
PubMed
PubMed Central
Google Scholar