Volume 7 Supplement 1

25th European Workshop for Rheumatology Research

Meeting abstracts

The organizer would like to thank the following companies who have generously supported the meeting: Abbott Immunology (Main sponsor), Bristol-Myers Squibb, Schering-Plough, Wyeth, AstraZeneca, MSD, Amgen

25th European Workshop for Rheumatology Research.

Glasgow, UK24-27 February 2005

Page 3 of 4

Interleukin-1 receptor antagonist lentiviral gene transfer to the murine knee joint ameliorates collagen-induced arthritis

Authors: FAJ van de Loo, LM Delavallee, OJ Arntz, MB Bennink, LAB Joosten and WB van den Berg

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P86

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Effects of anti-rheumatic treatments on the prostaglandin E₂ biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis

Authors: M Korotkova, M Westman, KR Gheorghe, E af Klint, C Trollmo, A-K Ulfgren, L Klareskog and P-J Jakobsson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P87

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Mitogen-activated kinases in psoriatic arthritis: differences in activation and distinct regulation by etanercept therapy

Authors: RJU Lories, I Derese, FP Luyten and K de Vlam

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P88

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Identification of a natural soluble form of the IL-18 receptor accessory protein as an immunomodulator in experimental arthritis

Authors: RL Smeets, OJ Arntz, MB Bennink, WB van den Berg and FAJ van de Loo

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P89

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Gene expression in chronically activated Th cells

Authors: U Niesner, I Albrecht, R Baumgrass, M Janitz, H Lehrach, T Haeupl, J Grun, GR Burmester, A Grutzkau and A Radbruch

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P90

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Intracellular IL-1 receptor antagonist (icIL-1Ra1) does not antagonize growth inhibitory effects of pre-IL-1α in SaOS-2 cells

Authors: G Palmer, S Trolliet, D Talabot-Ayer, F Mézin, D Magne and C Gabay

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P91

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Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies

Authors: M Korotkova, S Barbasso, P-J Jakobsson and I Lundberg

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P92

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Quantifying the contribution of the second HLA-DRB1 susceptibility allele to the risk of rheumatoid arthritis: a meta-analysis

Authors: IA van Rossum, AH Zwinderman, PP Tak and N de Vries

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P93

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Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome

Authors: M Bombardieri, F Barone, G Proctor, FA van de Loo, WB van den Berg, G Valesini, IB McInnes and C Pitzalis

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P94

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Type 1 regulatory T cells in treatment of murine lupus

Authors: R Undeutsch, J Humrich, BH Hahn, F Hiepe, G Burmester, A Radbruch and G Riemekasten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P95

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Hearing improvement in a variant Muckle–Wells syndrome case in response to IL-1 receptor antagonism

Authors: M Rynne, C Maclean, MF McDermott and P Emery

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P96

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The cytokine memory of SmD1^83-119-autoantigen-specific Th cells of systemic lupus erythematosus patients

Authors: S Langer, D Langnickel, P Enghard, GR Burmester, F Hiepe and G Riemekasten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P97

Content type: Poster presentation Published on: 17 February 2005
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PTPN22 as a rheumatoid arthritis susceptibility but not severity gene

Authors: J Wesoly, VEH Carlton, A Chokkalingam, AHM van der Helm-van Mil, REM Toes, AB Begovic and TWJ Huizinga

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P98

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Tryptase as a PAR-2 activator in joint inflammation

Authors: EB Kelso, L Dunning, JC Lockhart, WR Ferrell, R Plevin and CP Sommerhoff

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P99

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HLA DR-DQ haplotypes and genotypes in patients with systemic lupus erythematosus with co-existing Sjogren's syndrome, systemic lupus erythematosus without Sjogren's syndrome and primary Sjogren's syndrome: clinical and laboratory associations

Authors: Ch Georgopoulou, E Zintzaras, M Papadimitropoulos, M Spyropoulou, A Stavropoulou, HM Moutsopoulos and MN Manoussakis

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P100

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Specific inhibition of FoxO transcription factors in rheumatoid arthritis synovial tissue

Authors: J Ludikhuize, TJM Smeets, M Vinkenoog, ME Sanders, PP Tak and KA Reedquist

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P101

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Quantitative and qualitative analysis of CD4⁺CD25⁺ regulatory T cells in systemic lupus erythematosus patients

Authors: M Bonelli, JS Smolen and C Scheinecker

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P102

Content type: Poster presentation Published on: 17 February 2005
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HSP70/J-protein chaperone machines: expression analysis in granulocytes

Authors: A Zgaga-Griesz, A Adolf, S Haak, R Rzepka and I Melchers

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P103

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Genotype-dependent NOS-3 expression and rheumatoid arthritis

Authors: M Cattaruzza, I Melchers and M Hecker

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P104

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Anti-high-density lipoprotein antibodies and lipoprotein characteristics in systemic lupus erythematosus-related cardiovascular disease

Authors: J Su, A Cederholm, E Hurt-Camejo, E Svenungsson and J Frostegård

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P105

Content type: Poster presentation Published on: 17 February 2005
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Discrepancy between jun/fosproto-oncogene mRNA and protein expression in the rheumatoid arthritis synovial membrane

Authors: R Huber, B Stuhlmüller, E Kunisch and RW Kinne

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P106

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Distinct biological properties of human mesenchymal stem cells from different sources

Authors: C De Bari, F Dell'Accio, J Vanlauwe, C Pitzalis and FP Luyten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P107

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Regulation of T-cell differentiation by IL-4R α-chain single nucleotide polymorphisms

Authors: A Skapenko, I Prots, S Mattyasovszky, CL Yoné, JR Kalden and H Schulze-Koops

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P108

Content type: Poster presentation Published on: 17 February 2005
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Role of IL-10 as a susceptibility factor for rheumatoid arthritis and cardiovascular disease

Authors: FAS Kurreeman, J De Vries, R Westendorp, AH Van Den Biggelaar, JJM Schonkeren, REM Toes and TWJ Huizinga

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P109

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Regulation of myeloid cell function and MHC class II expression by tumor necrosis factor

Authors: RB Mueller, A Skapenko, M Grunke, J Wendler, B Stuhlmuller, JR Kalden and H Schulze-Koops

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P110

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Specific contributions of H-Ras and N-Ras GTPases to T-lymphocyte oxidative stress and integrin-dependent retention in rheumatoid arthritis

Authors: PHJ Remans, ME Sanders, PP Tak and KA Reedquist

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P111

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Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis

Authors: E Lubberts, P Schwarzenberger, W Huang, JR Schurr, JJ Peschon, WB van den Berg and JK Kolls

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P112

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Different molecules at the surface of stimulated T cells induce IL-1beta, tumour necrosis factor and IL-1RA in human monocytes

Authors: D Burger, N Molnarfi, L Gruaz and JM Dayer

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P113

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Infliximab treatment does not induce apoptosis in peripheral blood mononuclear cells up to 24 hours after initiation of treatment in rheumatoid arthritis patients

Authors: CA Wijbrandts, P Reinders-Blankert, P Klarenbeek, TJM Smeets, MJ Vervoordeldonk and PP Tak

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P114

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Resistance of rheumatoid arthritis synovial fibroblasts to p38 MAP-kinase inhibition of pro-destructive functions mediated by tumor necrosis factor alpha/tumor necrosis factor receptor-1

Authors: E Kunisch, B Ukena, R Fuhrmann, A Roth, R Winter and RW Kinne

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P115

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Patterns of gene expression in rheumatoid arthritis synovial tissue: inter-patient variability greater then intra-patient variability in a small study

Authors: J Lindberg, E af Klint, A Stark, T Andersson, P Nilsson, L Klareskog, A Ulfgren and J Lundeberg

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P116

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Association of FCGR2A and Fc gamma receptor haplotypes with Spanish polymyalgia rheumatica and giant cell arteritis

Authors: AW Morgan, MA Gonzalez-Gay, JI Robinson, SJ Babbage, L Haroon-Rashid, AH Hajeer, WER Ollier and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P117

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Noggin haploinsufficiency influences severity of arthritis in different mouse models

Authors: M Daans, RJU Lories, I Derese, P Tylzanowski and FP Luyten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P118

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Toll-like receptor expression in synovial fibroblasts and normal skin fibroblasts and induction of matrix metallo-proteinase expression by various Toll-like receptor ligands

Authors: D Kyburz, F Brentano, O Schorr, BA Michel, RE Gay and S Gay

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P119

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Exploring mechanisms of inflammatory hyperalgesia in murine collagen-induced arthritis

Authors: JJ Inglis, P Anand, P Facer, G Criado, M Feldmann and RO Williams

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P120

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Association of FCGR3A and FCGR3Bhaplotypes with rheumatoid arthritis and primary Sjögren's syndrome

Authors: S Mackie, JI Robinson, JH Barrett, CA Lawson, S Martin, L Haroon-Rashid, D Cooper, SJ Bowman, CT Pease, PG Conaghan, M Green, M Quinn, JD Isaacs, P Emery and AW Morgan

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P121

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Non-traditional risk and protective factors for cardiovascular disease in systemic lupus erythematosus

Authors: A Cederholm, E Svenungsson, D Stengel, G-Z Fei, AG Pockley, E Ninio and J Frostegård

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P122

Content type: Poster presentation Published on: 17 February 2005
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Immunomodulatory effect of unpulsed-immature dendritic cells in collagen-induced arthritis

Authors: PL Plence, F Apparailly, LM Van Duivenvoorde, LM Charbonnier, REM Toes and C Jorgensen

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P123

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Cytokine expression was assessed during antigen-induced arthritis in the synovial membrane, inguinal lymph node, and spleen using competitive RT-PCR and sandwich ELISA

Authors: RW Kinne, D Pohlers, A Siegling, E Buchner, CB Schmidt-Weber, E Palombo-Kinne, F Emmrich and R Bräuer

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P124

Content type: Poster presentation Published on: 17 February 2005
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Long-term immune reconstitution after autologous stem-cell transplantation for severe autoimmune diseases

Authors: T Alexander, G Massenkeil, E Gromnica-Ihle, GR Burmester, A Radbruch, R Arnold, F Hiepe and A Thiel

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P125

Content type: Poster presentation Published on: 17 February 2005
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The effect of B-cell depletion with an anti-CD20 antibody on the immunoglobulin heavy-chain repertoire in a patient with rheumatoid arthritis

Authors: A-S Rouzière, C Kneitz, T Dörner and H-P Tony

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P126

Content type: Poster presentation Published on: 17 February 2005
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Direct analysis of bone turnover in experimental arthritis

Authors: K Polzer, B Tuerk, K Redlich, S Hayer, J Smolen and G Schett

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P127

Content type: Poster presentation Published on: 17 February 2005
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Antibodies to ferritin in rheumatoid arthritis are associated with disease severity

Authors: D Mewar, DJ Moore, PF Watson and AG Wilson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P128

Content type: Poster presentation Published on: 17 February 2005
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Polymorphism within the telomeric MHC and expression of rheumatoid arthritis candidate genes

Authors: D Mewar, I Marinou, JM Timms, R Kilding and AG Wilson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P129

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Synovial monocytes mediate Rap1-dependent oxidative stress in rheumatoid arthritis T lymphocytes

Authors: PH Remans, JM van Laar, ME Sanders, P-P Tak and KA Reedquist

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P130

Content type: Poster presentation Published on: 17 February 2005
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Molecular response to cartilage injury

Authors: F Dell'Accio, C De Bari and C Pitzalis

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P131

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Binding properties of anti-histone H1 antibodies suggest that nuclei of necrotic cells rather than cells undergoing apoptosis are engulfed in the LE cell phenomenon

Authors: E Feierl, JS Smolen, T Karonitsch, GH Stummvoll, H Ekhart, CW Steiner and M Aringer

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P132

Content type: Poster presentation Published on: 17 February 2005
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Stat1 and phosphorylated Stat1 are increased in lymphocytes and monocytes of patients with systemic lupus erythematosus

Authors: M Aringer, T Karonitsch, CW Steiner, E Feierl, G Steiner and JS Smolen

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P133

Content type: Poster presentation Published on: 17 February 2005
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Kinetic and influence of angiogenesis in the course of collagen-induced arthritis

Authors: G Clavel, C Valvason, D Lemeiter, M-C Boissier and N Bessis

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P134

Content type: Poster presentation Published on: 17 February 2005
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Free radicals regulate glucocorticoid-induced apoptosis in T lymphocytes

Authors: PHJ Remans, DM Gerlag, MS Sanders, P Reinders-Blankert, KA Reedquist and PP Tak

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P135

Content type: Poster presentation Published on: 17 February 2005
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25th European Workshop for Rheumatology Research

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