Skip to main content

Articles

Page 102 of 155

  1. Cellular activation, proliferation and survival in chronic inflammatory diseases is regulated not only by engagement of signal trans-duction pathways that modulate transcription factors required for these proc...

    Authors: Aleksander M Grabiec, Paul P Tak and Kris A Reedquist
    Citation: Arthritis Research & Therapy 2008 10:226
    Content type: Review Published on:

  2. A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages ...

    Authors: Iannis E Adamopoulos and Edward P Bowman
    Citation: Arthritis Research & Therapy 2008 10:225
    Content type: Review Published on:

  4. Nitric oxide (NO) is an important mediator in both health and disease. In addition to its effects on vascular tone and platelet function, it plays roles in inflammation and pain perception that may be of relev...

    Authors: Isla S Mackenzie, Daniel Rutherford and Thomas M MacDonald
    Citation: Arthritis Research & Therapy 2008 10(Suppl 2):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 2

  5. Osteoarthritis (OA) is a degenerative disease involving chondrocytes, cartilage and other joint tissues, and has a number of underlying causes, including both biochemical and mechanical factors. Although proin...

    Authors: Steven B Abramson
    Citation: Arthritis Research & Therapy 2008 10(Suppl 2):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 2

  6. T-cell biology has regained importance in the pathogenesis of rheumatoid arthritis. Despite the significant improvements associated with the introduction of tumor necrosis factor-α blockade, reasonable proport...

    Authors: Maya H Buch, Edward M Vital and Paul Emery
    Citation: Arthritis Research & Therapy 2008 10(Suppl 1):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  7. Currently available information from clinical trials and open-label extensions suggest that abatacept is a good alternative to other biologicals in rheumatoid arthritis. Although at first glance the efficacy o...

    Authors: Rene Westhovens and Patrick Verschueren
    Citation: Arthritis Research & Therapy 2008 10(Suppl 1):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  8. T-cell activation and differentiation depend on the signal strength received by the T-cell receptor and on signals provided by co-stimulatory molecules. The most prominent co-stimulatory molecule is CD28, whic...

    Authors: Jörg J Goronzy and Cornelia M Weyand
    Citation: Arthritis Research & Therapy 2008 10(Suppl 1):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  9. This review focuses on the contributions made by interactions between dendritic cells (DCs) and T cells, and by local production of cytokines and chemokines to the pathogenesis of rheumatoid arthritis (RA) syn...

    Authors: Pierre Miossec
    Citation: Arthritis Research & Therapy 2008 10(Suppl 1):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  10. Over the past decade and a half, advances in our understanding of the pathogenesis of immune-mediated diseases such as rheumatoid arthritis (RA) have translated directly into benefit for patients. Much of this...

    Authors: Andrew P Cope
    Citation: Arthritis Research & Therapy 2008 10(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  11. The purpose of this study was to determine if oral administration of the interleukin (IL) 12/IL-23 inhibitor, STA-5326, is effective in experimental autoimmune uveoretinitis (EAU).

    Authors: Hiroshi Keino, Takayo Watanabe, Yasuhiko Sato, Mamoru Niikura, Yumiko Wada and Annabelle A Okada
    Citation: Arthritis Research & Therapy 2008 10:R122
    Content type: Research article Published on:

  12. RP105 is a Toll-like receptor homolog expressed on B cells, dendritic cells (DCs), and macrophages. We investigated the role of RP105 in the development of collagen-induced arthritis (CIA).

    Authors: Yoshifumi Tada, Syuichi Koarada, Fumitaka Morito, Mio Mitamura, Hisako Inoue, Rie Suematsu, Akihide Ohta, Kensuke Miyake and Kohei Nagasawa
    Citation: Arthritis Research & Therapy 2008 10:R121
    Content type: Research article Published on:

  14. Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differenti...

    Authors: Faye H Chen and Rocky S Tuan
    Citation: Arthritis Research & Therapy 2008 10:223
    Content type: Review Published on:

  15. Modern imaging modalities, including magnetic resonance imaging (MRI), are valuable diagnostic and therapy monitoring tools in rheumatoid arthritis (RA). This article reviewed how these imaging modalities have...

    Authors: Dennis McGonagle and Ai Lyn Tan
    Citation: Arthritis Research & Therapy 2008 10:222
    Content type: Review Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2009 11:401

  18. Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the in...

    Authors: Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap and Steffen Gay
    Citation: Arthritis Research & Therapy 2008 10:219
    Content type: Review Published on:

  19. Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility ...

    Authors: Stacy P Ardoin and David S Pisetsky
    Citation: Arthritis Research & Therapy 2008 10:218
    Content type: Review Published on:

  20. Immunoablative therapy and hematopoietic stem cell transplantation (HSCT) is an intensive treatment modality aimed at 'resetting' the dysregulated immune system of a patient with immunoablative therapy and all...

    Authors: Thomas Hügle and Jacob M van Laar
    Citation: Arthritis Research & Therapy 2008 10:217
    Content type: Review Published on:

  21. Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as...

    Authors: Stefan K Drexler, Philip L Kong, Jeremy Wales and Brian M Foxwell
    Citation: Arthritis Research & Therapy 2008 10:216
    Content type: Review Published on:

  23. Bone marrow oedema (BME) and avascular osteonecrosis (AVN) are disorders of unclear origin. Although there are numerous operative and non-operative treatments for AVN, pain management in patients with AVN rema...

    Authors: Marcus Jäger, Frank Peter Tillmann, Thomas S Thornhill, Marcus Mahmoudi, Dirk Blondin, Gerd Rüdiger Hetzel, Christoph Zilkens and Rüdiger Krauspe
    Citation: Arthritis Research & Therapy 2008 10:R120
    Content type: Research article Published on:

  24. Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, little is known about their origins and contribution to pathogenesis. Citrullination is the post-translationa...

    Authors: Brian A Kidd, Peggy P Ho, Orr Sharpe, Xiaoyan Zhao, Beren H Tomooka, Jennifer L Kanter, Lawrence Steinman and William H Robinson
    Citation: Arthritis Research & Therapy 2008 10:R119
    Content type: Research article Published on:

  25. We investigated the ability of a weekly intra-articular injection of bone morphogenetic protein (BMP)-7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections.

    Authors: Masaya Hayashi, Takeshi Muneta, Young-Jin Ju, Tomoyuki Mochizuki and Ichiro Sekiya
    Citation: Arthritis Research & Therapy 2008 10:R118
    Content type: Research article Published on:

  26. Gelsolin is an intracellular actin-binding protein involved in cell shape changes, cell motility, and apoptosis. An extracellular gelsolin isoform, plasma gelsolin circulates in the blood of healthy individual...

    Authors: Teresia M Osborn, Margareta Verdrengh, Thomas P Stossel, Andrej Tarkowski and Maria Bokarewa
    Citation: Arthritis Research & Therapy 2008 10:R117
    Content type: Research article Published on:

  27. Despite the substantial prevalence of gout in the ageing female population, female hormonal influence has not been comprehensively examined. We evaluated and quantified the potential independent association be...

    Authors: A Elisabeth Hak and Hyon K Choi
    Citation: Arthritis Research & Therapy 2008 10:R116
    Content type: Research article Published on:

  28. Rheumatoid arthritis is a chronic systemic autoimmune disease affecting peripheral joints and leading to loss of joint function. The severity and outcome of disease are dependent on the balance between inflamm...

    Authors: Melina Daans, Rik JU Lories and Frank P Luyten
    Citation: Arthritis Research & Therapy 2008 10:R115
    Content type: Research article Published on:

  29. There is a growing body of evidence implicating aberrant dendritic cell function as a crucial component in the immunopathogenesis of systemic lupus erythematosus. The purpose of the present study was to charac...

    Authors: Seetha U Monrad, Kristine Rea, Seth Thacker and Mariana J Kaplan
    Citation: Arthritis Research & Therapy 2008 10:R114
    Content type: Research article Published on:

  32. In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive...

    Authors: Walther J van Venrooij and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2008 10:117
    Content type: Editorial Published on:

  34. Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded adjacently to STAT4 on 2q32.2-q32.3, upregu...

    Authors: Aya Kawasaki, Ikue Ito, Koki Hikami, Jun Ohashi, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Satoshi Ito, Akito Tsutsumi, Minori Koga, Tadao Arinami, Robert R Graham, Geoffrey Hom, Yoshinari Takasaki, Hiroshi Hashimoto, Timothy W Behrens…
    Citation: Arthritis Research & Therapy 2008 10:R113
    Content type: Research article Published on:

  36. Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with a heterogeneous course and varying degrees of severity and organ damage; thus, there is increasing interest in identifying biomarker...

    Authors: Qiong Fu, Xiaoqing Chen, Huijuan Cui, Yanzhi Guo, Jing Chen, Nan Shen and Chunde Bao
    Citation: Arthritis Research & Therapy 2008 10:R112
    Content type: Research article Published on:

  38. Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1...

    Authors: Kolja Gelse, David Pfander, Simon Obier, Karl X Knaup, Michael Wiesener, Friedrich F Hennig and Bernd Swoboda
    Citation: Arthritis Research & Therapy 2008 10:R111
    Content type: Research article Published on:

  39. Although natural autoantibodies make up the majority of circulating immunoglobulins and are also present in high numbers in therapeutically used intravenous immunoglobulin preparations, they have received litt...

    Authors: Bence György, László Tóthfalusi, György Nagy, Mária Pásztói, Pál Géher, Zsolt Lörinc, Anna Polgár, Bernadett Rojkovich, Ilona Ujfalussy, Gyula Poór, Péter Pócza, Zoltán Wiener, Petra Misják, Agnes Koncz, András Falus and Edit I Buzás
    Citation: Arthritis Research & Therapy 2008 10:R110
    Content type: Research article Published on:

  40. This trial evaluated the safety, biologic activity, and pharmacokinetics of belimumab, a fully human monoclonal antibody that inhibits the biologic activity of the soluble form of the essential B-cell survival...

    Authors: Richard Furie, William Stohl, Ellen M Ginzler, Michael Becker, Nilamadhab Mishra, Winn Chatham, Joan T Merrill, Arthur Weinstein, W Joseph McCune, John Zhong, Wendy Cai and William Freimuth
    Citation: Arthritis Research & Therapy 2008 10:R109
    Content type: Research article Published on:

  41. Systemic lupus erythematosus is a genetically complex disease. Currently, the precise allelic polymorphisms associated with this condition remain largely unidentified. In part this reflects the fact that multi...

    Authors: Joan Wither, Yong-chun Cai, Sooyeol Lim, Tamara McKenzie, Nicole Roslin, Jaime O Claudio, Glinda S Cooper, Thomas J Hudson, Andrew D Paterson, Celia MT Greenwood, Dafna Gladman, Janet Pope, Christian A Pineau, C Douglas Smith, John G Hanly, Christine Peschken…
    Citation: Arthritis Research & Therapy 2008 10:R108
    Content type: Research article Published on:

  43. 4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts various effects on intracellular and extracellular signalling cascades. We have previously sh...

    Authors: France Vaillancourt, Hassan Fahmi, Qin Shi, Patrick Lavigne, Pierre Ranger, Julio C Fernandes and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2008 10:R107
    Content type: Research article Published on:

  44. The objectives of this study were to determine the predictive factors of long-term radiographic outcome of rheumatoid arthritis (RA) and to describe the relationship between joint damage and disability over th...

    Authors: Natacha Courvoisier, Maxime Dougados, Alain Cantagrel, Philippe Goupille, Olivier Meyer, Jean Sibilia, Jean Pierre Daures and Bernard Combe
    Citation: Arthritis Research & Therapy 2008 10:R106
    Content type: Research article Published on:

  45. The purpose of this study was to quantitatively evaluate the contribution of synovial lymphoid aggregates to autoantibody (rheumatoid factor [RF] and anti-cyclic citrullinated peptide [anti-CCP]) and total imm...

    Authors: Sanna Rosengren, Nathan Wei, Kenneth C Kalunian, Nathan J Zvaifler, Arthur Kavanaugh and David L Boyle
    Citation: Arthritis Research & Therapy 2008 10:R105
    Content type: Research article Published on:

  46. Spinal inflammation as detected by magnetic resonance imaging and new bone formation as identified by conventional radiographs are characteristic of ankylosing spondylitis. Whether and how spondylitis and synd...

    Authors: Xenofon Baraliakos, Joachim Listing, Martin Rudwaleit, Joachim Sieper and Juergen Braun
    Citation: Arthritis Research & Therapy 2008 10:R104
    Content type: Research article Published on:

  47. Platelet aggregation may contribute to the pathogenesis of systemic sclerosis: following activation, platelets release significant amounts of serotonin – which promotes vasoconstriction and fibrosis, and furth...

    Authors: Lorenzo Beretta, Marta Cossu, Maurizio Marchini, Francesca Cappiello, Andrea Artoni, Giovanna Motta and Raffaella Scorza
    Citation: Arthritis Research & Therapy 2008 10:R103
    Content type: Research article Published on:

  48. In this review, the authors discuss the formation and structure of high-density lipoproteins (HDLs) and how those particles are altered in inflammatory or stress states to lose their capacity for reverse chole...

    Authors: Bevra H Hahn, Jennifer Grossman, Benjamin J Ansell, Brian J Skaggs and Maureen McMahon
    Citation: Arthritis Research & Therapy 2008 10:213
    Content type: Review Published on:

  49. Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs).

    Authors: David J Hunter, Michael LaValley, Jiang Li, Doug C Bauer, Michael Nevitt, Jeroen DeGroot, Robin Poole, David Eyre, Ali Guermazi, Daniel Gale, Saara Totterman and David T Felson
    Citation: Arthritis Research & Therapy 2008 10:R102
    Content type: Research article Published on:

  50. Ankylosing spondylitis (AS) is a severe, chronic inflammatory arthritis, with a strong association to the human major histocompatibilty complex (MHC) class I allele human leucocyte antigen (HLA) B27. Disulfide...

    Authors: Susana G Santos, Sarah Lynch, Elaine C Campbell, Antony N Antoniou and Simon J Powis
    Citation: Arthritis Research & Therapy 2008 10:R100
    Content type: Research article Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us